(26 nodes) Regulation of histone H3-K4 methylation network (Latimeria chalumnae)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	ZNF335	Zinc finger protein 335. (1379 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	GATA3	GATA binding protein 3. (447 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (528 aa)
	WDR61	WD_REPEATS_REGION domain-containing protein. (305 aa)
	LOC102347456	Uncharacterized protein. (701 aa)
	BRCA1	BRCA1 DNA repair associated. (1873 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (820 aa)
	AUTS2	Activator of transcription and developmental regulator AUTS2. (1021 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	PYGO2	Pygopus family PHD finger 2. (401 aa)
	KANSL2	KAT8 regulatory NSL complex subunit 2. (531 aa)
	BCOR	BCL6 corepressor. (1779 aa)
	H3AS02_LATCH	Uncharacterized protein. (291 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (370 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
	PIH1D1	Uncharacterized protein. (294 aa)
	SNW1	SNW domain containing 1. (536 aa)
	KANSL1	KAT8 regulatory NSL complex subunit 1. (1112 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	KMT2E	Lysine methyltransferase 2E. (1846 aa)
	PHF20	PHD finger protein 20. (1026 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1163 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	MCRS1	Microspherule protein 1. (479 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	CTNNB1	ENSLACP00000006740	ENSLACP00000017209	BRCA1 DNA repair associated.	Catenin beta 1.	0.424
BRCA1	DNMT1	ENSLACP00000006740	ENSLACP00000012502	BRCA1 DNA repair associated.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.468
BRCA1	MACROH2A1	ENSLACP00000006740	ENSLACP00000013357	BRCA1 DNA repair associated.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.525
CTNNB1	BRCA1	ENSLACP00000017209	ENSLACP00000006740	Catenin beta 1.	BRCA1 DNA repair associated.	0.424
CTNNB1	DNMT1	ENSLACP00000017209	ENSLACP00000012502	Catenin beta 1.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.502
CTNNB1	KDM1A	ENSLACP00000017209	ENSLACP00000008333	Catenin beta 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.464
CTNNB1	LOC102358988	ENSLACP00000017209	ENSLACP00000022115	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.627
CTNNB1	PYGO2	ENSLACP00000017209	ENSLACP00000011098	Catenin beta 1.	Pygopus family PHD finger 2.	0.773
CTNNB1	SMAD4	ENSLACP00000017209	ENSLACP00000009312	Catenin beta 1.	MH2 domain-containing protein.	0.627
CTR9	H3AS02_LATCH	ENSLACP00000020869	ENSLACP00000012423	CTR9 homolog, Paf1/RNA polymerase II complex component.	Uncharacterized protein.	0.971
CTR9	MACROH2A1	ENSLACP00000020869	ENSLACP00000013357	CTR9 homolog, Paf1/RNA polymerase II complex component.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.541
CTR9	RTF1	ENSLACP00000020869	ENSLACP00000004296	CTR9 homolog, Paf1/RNA polymerase II complex component.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.999
CTR9	WDR61	ENSLACP00000020869	ENSLACP00000005707	CTR9 homolog, Paf1/RNA polymerase II complex component.	WD_REPEATS_REGION domain-containing protein.	0.971
DNMT1	BRCA1	ENSLACP00000012502	ENSLACP00000006740	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	BRCA1 DNA repair associated.	0.468
DNMT1	CTNNB1	ENSLACP00000012502	ENSLACP00000017209	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Catenin beta 1.	0.502
DNMT1	KDM1A	ENSLACP00000012502	ENSLACP00000008333	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.779
DNMT1	MACROH2A1	ENSLACP00000012502	ENSLACP00000013357	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.407
GATA3	MYB	ENSLACP00000003446	ENSLACP00000003141	GATA binding protein 3.	MYB proto-oncogene, transcription factor.	0.604
H3AS02_LATCH	CTR9	ENSLACP00000012423	ENSLACP00000020869	Uncharacterized protein.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.971
H3AS02_LATCH	RTF1	ENSLACP00000012423	ENSLACP00000004296	Uncharacterized protein.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.863