STRINGSTRING
BCKDHB BCKDHB HCN4 HCN4 EEF2K EEF2K CFTR CFTR DGKQ DGKQ DUOX2 DUOX2 PKD2 PKD2 EZR EZR PDE2A PDE2A VGF VGF PIK3CG PIK3CG INPP5K INPP5K H3AEK5_LATCH H3AEK5_LATCH IGFBP5 IGFBP5 H3AF01_LATCH H3AF01_LATCH KDM1A KDM1A H3AFD4_LATCH H3AFD4_LATCH AREG AREG H3AHJ4_LATCH H3AHJ4_LATCH KCNQ1 KCNQ1 GATA1 GATA1 RAPGEF2 RAPGEF2 AKAP6 AKAP6 SLC26A3 SLC26A3 LOC102350018 LOC102350018 NDUFS4 NDUFS4 AKAP7 AKAP7 CITED1 CITED1 PPARGC1B PPARGC1B LOC102362971 LOC102362971 RAP1B RAP1B CRHBP CRHBP HCN2 HCN2 AQP8 AQP8 FOSL1 FOSL1 H3B1J8_LATCH H3B1J8_LATCH KCNE1 KCNE1 HCN1 HCN1 AANAT AANAT CARM1 CARM1 WT1 WT1 LOC102362765 LOC102362765 DMTN DMTN LOC102349421 LOC102349421 RAPGEF1 RAPGEF1 RAP1A RAP1A RAPGEF3 RAPGEF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (217 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1184 aa)
EEF2KEukaryotic elongation factor 2 kinase. (512 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
DGKQDiacylglycerol kinase. (940 aa)
DUOX2Dual oxidase 2. (1551 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (890 aa)
EZREzrin. (591 aa)
PDE2APhosphodiesterase. (705 aa)
VGFVGF nerve growth factor inducible. (438 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (476 aa)
H3AEK5_LATCHAquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
IGFBP5Insulin like growth factor binding protein 5. (279 aa)
H3AF01_LATCHUncharacterized protein. (658 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (820 aa)
H3AFD4_LATCHCyclic nucleotide-binding domain-containing protein. (486 aa)
AREGAmphiregulin. (235 aa)
H3AHJ4_LATCHIon_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
GATA1GATA binding protein 1b. (432 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1514 aa)
AKAP6Uncharacterized protein. (901 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (669 aa)
LOC102350018CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (462 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (169 aa)
AKAP7A-kinase anchoring protein 7. (427 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (165 aa)
PPARGC1BPPARG coactivator 1 beta. (986 aa)
LOC102362971Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (946 aa)
AQP8Aquaporin 8a, tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (268 aa)
H3B1J8_LATCHAKAP7_NLS domain-containing protein. (240 aa)
KCNE1Uncharacterized protein. (122 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (473 aa)
AANATAralkylamine N-acetyltransferase. (205 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (560 aa)
WT1WT1 transcription factor. (422 aa)
LOC102362765Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
DMTNDematin actin binding protein. (406 aa)
LOC102349421Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1217 aa)
RAP1ARAP1A, member of RAS oncogene family b. (185 aa)
RAPGEF3Ras-GEF domain-containing protein. (459 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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