(59 nodes) Positive regulation of protein kinase B signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	CASS4	Cas scaffold protein family member 4. (817 aa)
	C1QTNF1	C1q and TNF related 1. (229 aa)
	H3B924_LATCH	TGF_BETA_2 domain-containing protein. (356 aa)
	STOX1	Storkhead box 1. (891 aa)
	LOC102362769	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
	H3B8G4_LATCH	Uncharacterized protein. (110 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	CSF3	Colony stimulating factor 3. (210 aa)
	MEIS3	Meis homeobox 3. (452 aa)
	GAS6	Uncharacterized protein. (681 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	HAX1	HCLS1 associated protein X-1. (249 aa)
	FAM110A	Family with sequence similarity 110 member A. (369 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	LOC102362971	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
	LOC102354453	Uncharacterized protein. (230 aa)
	BAG4	BCL2 associated athanogene 4. (454 aa)
	NOX4	NADPH oxidase 4. (541 aa)
	FAM110B	Family with sequence similarity 110 member B. (370 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	TEK	TEK receptor tyrosine kinase. (914 aa)
	MYOC	Myocilin. (272 aa)
	CD28	Ig-like domain-containing protein. (202 aa)
	PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1006 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	TNFAIP8L3	TNF alpha induced protein 8 like 3. (187 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (279 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	RASD2	RASD family member 2. (271 aa)
	PHB	Prohibitin. (272 aa)
	HBEGF	Heparin binding EGF like growth factor. (209 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1664 aa)
	FAM110C	Family with sequence similarity 110 member C. (363 aa)
	GFRAL	GDNF family receptor alpha like. (220 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	RET	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
	F3	Coagulation factor III, tissue factor. (286 aa)
	GATA3	GATA binding protein 3. (447 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (855 aa)
	RAMP3	Receptor activity modifying protein 3. (117 aa)
	C1QTNF6	C1q and TNF related 6. (273 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (635 aa)
	LOC102358504	SCY domain-containing protein. (118 aa)
	ENG	Endoglin. (674 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
	HPSE	Heparanase. (544 aa)
	C1QBP	Complement C1q binding protein. (335 aa)
	IL18	Uncharacterized protein. (200 aa)
	C1QTNF12	C1q and TNF related 12. (265 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	MYDGF	Myeloid derived growth factor. (85 aa)
	FAM110D	Family with sequence similarity 110 member D. (340 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	GAS6	ENSLACP00000020423	ENSLACP00000016134	AXL receptor tyrosine kinase.	Uncharacterized protein.	0.704
C1QBP	PHB	ENSLACP00000022197	ENSLACP00000006862	Complement C1q binding protein.	Prohibitin.	0.762
CSF3	LTA	ENSLACP00000016938	ENSLACP00000007765	Colony stimulating factor 3.	Lymphotoxin alpha.	0.472
CSF3	TNFSF11	ENSLACP00000016938	ENSLACP00000009224	Colony stimulating factor 3.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.444
ENG	TEK	ENSLACP00000023030	ENSLACP00000011084	Endoglin.	TEK receptor tyrosine kinase.	0.575
ENG	TGFB1	ENSLACP00000023030	ENSLACP00000020652	Endoglin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.781
ENG	TGFBR1	ENSLACP00000023030	ENSLACP00000008197	Endoglin.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.786
GAS6	AXL	ENSLACP00000016134	ENSLACP00000020423	Uncharacterized protein.	AXL receptor tyrosine kinase.	0.704
GFRAL	H3B924_LATCH	ENSLACP00000005823	ENSLACP00000018395	GDNF family receptor alpha like.	TGF_BETA_2 domain-containing protein.	0.959
GFRAL	RET	ENSLACP00000005823	ENSLACP00000004888	GDNF family receptor alpha like.	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.980
H3AEV1_LATCH	TNFSF11	ENSLACP00000008172	ENSLACP00000009224	TNF_2 domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.448
H3B924_LATCH	GFRAL	ENSLACP00000018395	ENSLACP00000005823	TGF_BETA_2 domain-containing protein.	GDNF family receptor alpha like.	0.959
H3B924_LATCH	RET	ENSLACP00000018395	ENSLACP00000004888	TGF_BETA_2 domain-containing protein.	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.852
IGF2	IGFBP5	ENSLACP00000004956	ENSLACP00000008147	Insulin like growth factor 2.	Insulin like growth factor binding protein 5.	0.881
IGF2	LEP	ENSLACP00000004956	ENSLACP00000011398	Insulin like growth factor 2.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.451
IGF2	TEK	ENSLACP00000004956	ENSLACP00000011084	Insulin like growth factor 2.	TEK receptor tyrosine kinase.	0.656
IGFBP5	IGF2	ENSLACP00000008147	ENSLACP00000004956	Insulin like growth factor binding protein 5.	Insulin like growth factor 2.	0.881
IGFBP5	THBS1	ENSLACP00000008147	ENSLACP00000020712	Insulin like growth factor binding protein 5.	Thrombospondin 1.	0.401
IL18	LOC102358504	ENSLACP00000021930	ENSLACP00000023507	Uncharacterized protein.	SCY domain-containing protein.	0.402
IL18	LTA	ENSLACP00000021930	ENSLACP00000007765	Uncharacterized protein.	Lymphotoxin alpha.	0.624