(55 nodes) Positive regulation of calcium ion transport network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	THY1	Thy-1 cell surface antigen. (165 aa)
	LOC102353789	G_PROTEIN_RECEP_F1_2 domain-containing protein. (344 aa)
	LOC102351466	Uncharacterized protein. (201 aa)
	LOC102355203	Na_H_Exchanger domain-containing protein. (161 aa)
	H2ZTT6_LATCH	Phosphoinositide phospholipase C. (404 aa)
	STIM2	Stromal interaction molecule 2. (639 aa)
	RAMP3	Receptor activity modifying protein 3. (117 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	H3A068_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (326 aa)
	LOC102352804	Phosphoinositide phospholipase C. (1172 aa)
	FFAR1	Free fatty acid receptor 1. (279 aa)
	STAC	SH3 and cysteine rich domain. (279 aa)
	LOC102363383	EF-hand domain-containing protein; Belongs to the S-100 family. (100 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	WNK3	WNK lysine deficient protein kinase 3. (1769 aa)
	H3A855_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (320 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	R3HDM1	R3H domain containing 1. (1107 aa)
	HTT	Huntingtin. (3125 aa)
	BAX	Uncharacterized protein. (223 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	H3AF01_LATCH	Uncharacterized protein. (658 aa)
	LOC102357829	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (313 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	H3AJC3_LATCH	Galectin. (249 aa)
	AKAP6	Uncharacterized protein. (901 aa)
	UCN	Urocortin. (167 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (692 aa)
	STIM1	Stromal interaction molecule 1. (662 aa)
	LOC102359041	Zgc:153993. (208 aa)
	TRPC1	Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (793 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (876 aa)
	CACNB4	Calcium channel, voltage-dependent, beta 4a subunit. (477 aa)
	HOMER1	Homer scaffold protein 1. (367 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	STAC2	SH3 and cysteine rich domain 2. (375 aa)
	STC1	Stanniocalcin 1. (250 aa)
	LOC102350639	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	H3B845_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (299 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	LOC102354490	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (403 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (256 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
	LOC102351798	Galectin. (167 aa)
	LGALS3	Galectin. (274 aa)
	R3HDM2	R3H domain containing 2. (971 aa)
	STAC3	SH3 and cysteine rich domain 3. (373 aa)
	LOC102352351	C-C motif chemokine. (88 aa)
	VMP1	Vacuole membrane protein 1. (406 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
	LOC102359410	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (430 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1R1	RAMP3	ENSLACP00000015179	ENSLACP00000002485	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 3.	0.533
ADCYAP1R1	UCN	ENSLACP00000015179	ENSLACP00000011213	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.596
AKAP6	H3AF01_LATCH	ENSLACP00000010706	ENSLACP00000008222	Uncharacterized protein.	Uncharacterized protein.	0.924
APLNR	LOC102354490	ENSLACP00000005842	ENSLACP00000020198	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.905
BAK1	BAX	ENSLACP00000018296	ENSLACP00000007049	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.985
BAK1	LOC102359041	ENSLACP00000018296	ENSLACP00000012675	BCL2 antagonist/killer 1.	Zgc:153993.	0.900
BAX	BAK1	ENSLACP00000007049	ENSLACP00000018296	Uncharacterized protein.	BCL2 antagonist/killer 1.	0.985
BAX	LOC102359041	ENSLACP00000007049	ENSLACP00000012675	Uncharacterized protein.	Zgc:153993.	0.975
CACNB4	STAC3	ENSLACP00000014759	ENSLACP00000021700	Calcium channel, voltage-dependent, beta 4a subunit.	SH3 and cysteine rich domain 3.	0.508
CAV3	STIM1	ENSLACP00000020888	ENSLACP00000012276	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Stromal interaction molecule 1.	0.477
CAV3	TRPC1	ENSLACP00000020888	ENSLACP00000013002	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.668
CDK5	HTT	ENSLACP00000009607	ENSLACP00000006612	Cyclin dependent kinase 5.	Huntingtin.	0.500
F2	H3A068_LATCH	ENSLACP00000021404	ENSLACP00000003039	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.923
F2	H3A855_LATCH	ENSLACP00000021404	ENSLACP00000005826	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.789
F2	LOC102353789	ENSLACP00000021404	ENSLACP00000000083	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.789
F2	LOC102357829	ENSLACP00000021404	ENSLACP00000008982	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.789
F2	LOC102359410	ENSLACP00000021404	ENSLACP00000022924	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.923
H2ZTT6_LATCH	PDGFB	ENSLACP00000000807	ENSLACP00000002907	Phosphoinositide phospholipase C.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.472
H3A068_LATCH	F2	ENSLACP00000003039	ENSLACP00000021404	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.923
H3A855_LATCH	F2	ENSLACP00000005826	ENSLACP00000021404	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.789