STRINGSTRING
ZFPM2 ZFPM2 PKP2 PKP2 ENG ENG LOC102358988 LOC102358988 HAND1 HAND1 TNNC1 TNNC1 TGFB1 TGFB1 NKX2-5 NKX2-5 LOC102350553 LOC102350553 PTCD2 PTCD2 DLL4 DLL4 MED1 MED1 TNNI1 TNNI1 LOC102353564 LOC102353564 H3APB2_LATCH H3APB2_LATCH H3AM65_LATCH H3AM65_LATCH SMAD4 SMAD4 TGFBR1 TGFBR1 SMAD7 SMAD7 EDNRA EDNRA TNNI3 TNNI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFPM2Zinc finger protein, FOG family member 2. (979 aa)
PKP2Uncharacterized protein. (815 aa)
ENGEndoglin. (674 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
HAND1Heart and neural crest derivatives expressed 1. (196 aa)
TNNC1Troponin C type 1a (slow). (164 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
NKX2-5NK2 homeobox 5. (296 aa)
LOC102350553Uncharacterized protein. (232 aa)
PTCD2Pentatricopeptide repeat domain 2. (405 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
TNNI1Troponin I1, slow skeletal type. (171 aa)
LOC102353564Uncharacterized protein. (161 aa)
H3APB2_LATCHFork-head domain-containing protein. (408 aa)
H3AM65_LATCHMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
SMAD4MH2 domain-containing protein. (412 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
TNNI3Uncharacterized protein. (240 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.