(42 nodes) Inner ear receptor cell differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRRC1	Uncharacterized protein. (155 aa)
	PDZD7	PDZ domain containing 7. (505 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	IFT88	Intraflagellar transport 88. (833 aa)
	SLITRK6	SLIT and NTRK like family member 6. (841 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (454 aa)
	H3A478_LATCH	PDZ domain-containing protein. (297 aa)
	H3A4S8_LATCH	Uncharacterized protein. (2030 aa)
	PJVK	Pejvakin. (355 aa)
	SLC4A7	Anion exchange protein. (1213 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (614 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1197 aa)
	CECR2	CECR2 histone acetyl-lysine reader. (1363 aa)
	GSDME	Uncharacterized protein. (491 aa)
	GRXCR1	Glutaredoxin and cysteine rich domain containing 1. (213 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	H3AHJ4_LATCH	Ion_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1230 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	H3AIG1_LATCH	Uncharacterized protein. (317 aa)
	PTPRQ	Protein tyrosine phosphatase receptor type Q. (1795 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
	ADGRV1	Adhesion G protein-coupled receptor V1. (5847 aa)
	H3ALU1_LATCH	Uncharacterized protein. (1358 aa)
	USH1G	USH1 protein network component sans. (471 aa)
	GRXCR2	Glutaredoxin and cysteine rich domain containing 2. (260 aa)
	PLS1	Plastin 1. (621 aa)
	LOC102350991	Uncharacterized protein. (1471 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	LOC102359345	Transmembrane O-methyltransferase. (268 aa)
	TPRN	Taperin. (771 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (151 aa)
	USH1C	USH1 protein network component harmonin. (830 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	H3BBK0_LATCH	Uncharacterized protein. (783 aa)
	IFT20	Intraflagellar transport 20. (132 aa)
	MKS1	MKS transition zone complex subunit 1. (561 aa)
	TRIP11	Thyroid hormone receptor interactor 11. (1997 aa)
	TTC8	Tetratricopeptide repeat domain 8. (534 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (727 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRV1	GRXCR1	ENSLACP00000010057	ENSLACP00000008466	Adhesion G protein-coupled receptor V1.	Glutaredoxin and cysteine rich domain containing 1.	0.441
ADGRV1	H3A478_LATCH	ENSLACP00000010057	ENSLACP00000004449	Adhesion G protein-coupled receptor V1.	PDZ domain-containing protein.	0.543
ADGRV1	H3A4S8_LATCH	ENSLACP00000010057	ENSLACP00000004649	Adhesion G protein-coupled receptor V1.	Uncharacterized protein.	0.535
ADGRV1	H3AIG1_LATCH	ENSLACP00000010057	ENSLACP00000009432	Adhesion G protein-coupled receptor V1.	Uncharacterized protein.	0.543
ADGRV1	LOC102350991	ENSLACP00000010057	ENSLACP00000012767	Adhesion G protein-coupled receptor V1.	Uncharacterized protein.	0.755
ADGRV1	MYO6	ENSLACP00000010057	ENSLACP00000009303	Adhesion G protein-coupled receptor V1.	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.582
ADGRV1	PDZD7	ENSLACP00000010057	ENSLACP00000000972	Adhesion G protein-coupled receptor V1.	PDZ domain containing 7.	0.873
ADGRV1	SLC4A7	ENSLACP00000010057	ENSLACP00000005931	Adhesion G protein-coupled receptor V1.	Anion exchange protein.	0.423
ADGRV1	TRIP11	ENSLACP00000010057	ENSLACP00000021639	Adhesion G protein-coupled receptor V1.	Thyroid hormone receptor interactor 11.	0.433
ADGRV1	TTC8	ENSLACP00000010057	ENSLACP00000022744	Adhesion G protein-coupled receptor V1.	Tetratricopeptide repeat domain 8.	0.557
ADGRV1	USH1C	ENSLACP00000010057	ENSLACP00000018193	Adhesion G protein-coupled receptor V1.	USH1 protein network component harmonin.	0.868
ADGRV1	USH1G	ENSLACP00000010057	ENSLACP00000012126	Adhesion G protein-coupled receptor V1.	USH1 protein network component sans.	0.690
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	JAG1	ENSLACP00000008690	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.486
GRXCR1	ADGRV1	ENSLACP00000008466	ENSLACP00000010057	Glutaredoxin and cysteine rich domain containing 1.	Adhesion G protein-coupled receptor V1.	0.441
GRXCR1	GRXCR2	ENSLACP00000008466	ENSLACP00000012476	Glutaredoxin and cysteine rich domain containing 1.	Glutaredoxin and cysteine rich domain containing 2.	0.618
GRXCR1	PJVK	ENSLACP00000008466	ENSLACP00000004760	Glutaredoxin and cysteine rich domain containing 1.	Pejvakin.	0.487