(18 nodes) Regulation of membrane repolarization network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNTA1	Syntrophin alpha 1. (481 aa)
	AKAP7	A-kinase anchoring protein 7. (427 aa)
	H3B1J8_LATCH	AKAP7_NLS domain-containing protein. (240 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (125 aa)
	KCNE1	Uncharacterized protein. (122 aa)
	NOS1AP	Uncharacterized protein. (192 aa)
	RNF207	Ring finger protein 207. (648 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (210 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (221 aa)
	KCNE3	Uncharacterized protein. (92 aa)
	KCNE4	Potassium voltage-gated channel subfamily E regulatory subunit 4. (167 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (371 aa)
	AKAP6	Uncharacterized protein. (901 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	H3AF01_LATCH	Uncharacterized protein. (658 aa)
	H3AHJ4_LATCH	Ion_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	H3AF01_LATCH	ENSLACP00000010706	ENSLACP00000008222	Uncharacterized protein.	Uncharacterized protein.	0.924
H3AF01_LATCH	AKAP6	ENSLACP00000008222	ENSLACP00000010706	Uncharacterized protein.	Uncharacterized protein.	0.924
H3AHJ4_LATCH	KCNE1	ENSLACP00000009115	ENSLACP00000016439	Ion_trans domain-containing protein; Belongs to the potassium channel family.	Uncharacterized protein.	0.977
H3AHJ4_LATCH	KCNE2	ENSLACP00000009115	ENSLACP00000015984	Ion_trans domain-containing protein; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.708
H3AHJ4_LATCH	KCNE3	ENSLACP00000009115	ENSLACP00000004959	Ion_trans domain-containing protein; Belongs to the potassium channel family.	Uncharacterized protein.	0.917
H3AHJ4_LATCH	KCNE4	ENSLACP00000009115	ENSLACP00000004269	Ion_trans domain-containing protein; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.681
KCNE1	H3AHJ4_LATCH	ENSLACP00000016439	ENSLACP00000009115	Uncharacterized protein.	Ion_trans domain-containing protein; Belongs to the potassium channel family.	0.977
KCNE1	KCNE3	ENSLACP00000016439	ENSLACP00000004959	Uncharacterized protein.	Uncharacterized protein.	0.590
KCNE1	KCNE4	ENSLACP00000016439	ENSLACP00000004269	Uncharacterized protein.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.459
KCNE1	KCNQ1	ENSLACP00000016439	ENSLACP00000009821	Uncharacterized protein.	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	0.784
KCNE1	NOS1AP	ENSLACP00000016439	ENSLACP00000016593	Uncharacterized protein.	Uncharacterized protein.	0.652
KCNE1	SCN4B	ENSLACP00000016439	ENSLACP00000021221	Uncharacterized protein.	Sodium voltage-gated channel beta subunit 4.	0.418
KCNE1	SNTA1	ENSLACP00000016439	ENSLACP00000012467	Uncharacterized protein.	Syntrophin alpha 1.	0.420
KCNE2	H3AHJ4_LATCH	ENSLACP00000015984	ENSLACP00000009115	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Ion_trans domain-containing protein; Belongs to the potassium channel family.	0.708
KCNE2	KCNE3	ENSLACP00000015984	ENSLACP00000004959	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Uncharacterized protein.	0.686
KCNE2	KCNE4	ENSLACP00000015984	ENSLACP00000004269	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily E regulatory subunit 4.	0.589
KCNE2	KCNQ1	ENSLACP00000015984	ENSLACP00000009821	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.	0.708
KCNE2	NOS1AP	ENSLACP00000015984	ENSLACP00000016593	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Uncharacterized protein.	0.511
KCNE2	SCN1B	ENSLACP00000015984	ENSLACP00000005402	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Sodium voltage-gated channel beta subunit 1.	0.429
KCNE2	SCN4B	ENSLACP00000015984	ENSLACP00000021221	Potassium voltage-gated channel subfamily E regulatory subunit 2.	Sodium voltage-gated channel beta subunit 4.	0.553