(25 nodes) Face development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102357376	CSRNP_N domain-containing protein. (152 aa)
	DLX5	Distal-less homeobox 5. (290 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (1006 aa)
	MSX1	Msh homeobox 1. (256 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	NIPBL	Nipped-B protein. (2707 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	CRISPLD2	Cysteine rich secretory protein LCCL domain containing 2; Belongs to the CRISP family. (508 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	CRISPLD1	Cysteine rich secretory protein LCCL domain containing 1; Belongs to the CRISP family. (299 aa)
	ZFAND5	Zinc finger AN1-type containing 5. (215 aa)
	ANKRD11	Ankyrin repeat domain 11. (2717 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (566 aa)
	LOC102347076	Uncharacterized protein. (232 aa)
	SRF	Serum response factor. (520 aa)
	HOXB3	Homeobox B3. (404 aa)
	PAX9	Paired box 9. (342 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (507 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	STRA6	Stimulated by retinoic acid 6. (664 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A3	STRA6	ENSLACP00000020368	ENSLACP00000023604	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid 6.	0.411
CRISPLD2	MSX1	ENSLACP00000007030	ENSLACP00000004473	Cysteine rich secretory protein LCCL domain containing 2; Belongs to the CRISP family.	Msh homeobox 1.	0.405
DLX5	EDNRA	ENSLACP00000001948	ENSLACP00000006100	Distal-less homeobox 5.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.590
EDNRA	DLX5	ENSLACP00000006100	ENSLACP00000001948	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Distal-less homeobox 5.	0.590
LEF1	LOC102352539	ENSLACP00000005598	ENSLACP00000009233	Lymphoid enhancer binding factor 1.	Uncharacterized protein.	0.789
LEF1	LOC102358266	ENSLACP00000005598	ENSLACP00000005525	Lymphoid enhancer binding factor 1.	Dickkopf WNT signaling pathway inhibitor 1b.	0.689
LEF1	MSX1	ENSLACP00000005598	ENSLACP00000004473	Lymphoid enhancer binding factor 1.	Msh homeobox 1.	0.628
LEF1	PAX9	ENSLACP00000005598	ENSLACP00000018070	Lymphoid enhancer binding factor 1.	Paired box 9.	0.429
LOC102352539	LEF1	ENSLACP00000009233	ENSLACP00000005598	Uncharacterized protein.	Lymphoid enhancer binding factor 1.	0.789
LOC102352539	TGFB1	ENSLACP00000009233	ENSLACP00000020652	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.613
LOC102357376	MSX1	ENSLACP00000000014	ENSLACP00000004473	CSRNP_N domain-containing protein.	Msh homeobox 1.	0.575
LOC102358266	LEF1	ENSLACP00000005525	ENSLACP00000005598	Dickkopf WNT signaling pathway inhibitor 1b.	Lymphoid enhancer binding factor 1.	0.689
MSX1	CRISPLD2	ENSLACP00000004473	ENSLACP00000007030	Msh homeobox 1.	Cysteine rich secretory protein LCCL domain containing 2; Belongs to the CRISP family.	0.405
MSX1	LEF1	ENSLACP00000004473	ENSLACP00000005598	Msh homeobox 1.	Lymphoid enhancer binding factor 1.	0.628
MSX1	LOC102357376	ENSLACP00000004473	ENSLACP00000000014	Msh homeobox 1.	CSRNP_N domain-containing protein.	0.575
MSX1	PAX9	ENSLACP00000004473	ENSLACP00000018070	Msh homeobox 1.	Paired box 9.	0.816
MSX1	TGFB3	ENSLACP00000004473	ENSLACP00000018912	Msh homeobox 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.477
PAX9	LEF1	ENSLACP00000018070	ENSLACP00000005598	Paired box 9.	Lymphoid enhancer binding factor 1.	0.429
PAX9	MSX1	ENSLACP00000018070	ENSLACP00000004473	Paired box 9.	Msh homeobox 1.	0.816
STRA6	ALDH1A3	ENSLACP00000023604	ENSLACP00000020368	Stimulated by retinoic acid 6.	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	0.411