STRINGSTRING
SMAD7 SMAD7 SMAD6 SMAD6 TGFBR2 TGFBR2 LOC102350164 LOC102350164 GATA6 GATA6 SMO SMO JAG1 JAG1 ZFPM2 ZFPM2 TBX3 TBX3 H3AC70_LATCH H3AC70_LATCH FGF8 FGF8 TGFBR1 TGFBR1 SMAD4 SMAD4 SEMA3C SEMA3C ACVR1 ACVR1 DHRS3 DHRS3 NSD2 NSD2 TBX20 TBX20 SLIT2 SLIT2 SAV1 SAV1 NRP2 NRP2 TP53 TP53 NKX2-5 NKX2-5 BMPR2 BMPR2 TBX2 TBX2 CCN1 CCN1 BMP7 BMP7 SLIT3 SLIT3 ENG ENG LOC102358988 LOC102358988 H3BEX6_LATCH H3BEX6_LATCH ZFPM1 ZFPM1 HAND1 HAND1 MKS1 MKS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD7Mothers against decapentaplegic homolog. (377 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
LOC102350164Uncharacterized protein. (364 aa)
GATA6GATA binding protein 6. (503 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
ZFPM2Zinc finger protein, FOG family member 2. (979 aa)
TBX3T-box transcription factor 3. (713 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
SMAD4MH2 domain-containing protein. (412 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (550 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (303 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1348 aa)
TBX20T-box transcription factor 20. (441 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
SAV1Salvador family WW domain containing protein 1. (393 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (929 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
NKX2-5NK2 homeobox 5. (296 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
TBX2T-box transcription factor 2. (689 aa)
CCN1Cellular communication network factor 1. (368 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
SLIT3Slit guidance ligand 3. (635 aa)
ENGEndoglin. (674 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1017 aa)
HAND1Heart and neural crest derivatives expressed 1. (196 aa)
MKS1MKS transition zone complex subunit 1. (561 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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