STRINGSTRING
WNT2B WNT2B TGFBR2 TGFBR2 RDH10 RDH10 DLG5 DLG5 TCF21 TCF21 CTSH CTSH SEC24B SEC24B FGF8 FGF8 H3AFZ1_LATCH H3AFZ1_LATCH HPS1 HPS1 DAG1 DAG1 HHIP HHIP SRF SRF CTSZ CTSZ CTNNB1 CTNNB1 SPRY1 SPRY1 WNT2 WNT2 STK40 STK40 HOXA5 HOXA5 ESRP2 ESRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (348 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
TCF21Transcription factor 21. (179 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1197 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
H3AFZ1_LATCHPeptidase S72 domain-containing protein. (633 aa)
HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (699 aa)
DAG1Dystroglycan 1. (900 aa)
HHIPHedgehog interacting protein. (687 aa)
SRFSerum response factor. (520 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (295 aa)
CTNNB1Catenin beta 1. (781 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
STK40Serine/threonine kinase 40. (445 aa)
HOXA5Homeobox A5. (269 aa)
ESRP2Epithelial splicing regulatory protein 2. (721 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: very high (>100%) [HD]