(13 nodes) Trachea development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3A2S4_LATCH	Uncharacterized protein. (431 aa)
	H2ZYG4_LATCH	Uncharacterized protein. (422 aa)
	H2ZTJ9_LATCH	ASH domain-containing protein. (708 aa)
	H3AN97_LATCH	Uncharacterized protein. (830 aa)
	LOC102356233	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
	HOXA5	Homeobox A5. (269 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SRF	Serum response factor. (520 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (223 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	H3AE15_LATCH	Uncharacterized protein. (430 aa)
	HYDIN	Hydin_ADK domain-containing protein. (361 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	LEF1	ENSLACP00000017209	ENSLACP00000005598	Catenin beta 1.	Lymphoid enhancer binding factor 1.	0.999
CTNNB1	LOC102356233	ENSLACP00000017209	ENSLACP00000022578	Catenin beta 1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.435
CTNNB1	TGFBR2	ENSLACP00000017209	ENSLACP00000004468	Catenin beta 1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.530
H2ZTJ9_LATCH	H2ZYG4_LATCH	ENSLACP00000000720	ENSLACP00000002435	ASH domain-containing protein.	Uncharacterized protein.	0.949
H2ZTJ9_LATCH	H3A2S4_LATCH	ENSLACP00000000720	ENSLACP00000003945	ASH domain-containing protein.	Uncharacterized protein.	0.949
H2ZTJ9_LATCH	H3AE15_LATCH	ENSLACP00000000720	ENSLACP00000007886	ASH domain-containing protein.	Uncharacterized protein.	0.949
H2ZTJ9_LATCH	H3AN97_LATCH	ENSLACP00000000720	ENSLACP00000011118	ASH domain-containing protein.	Uncharacterized protein.	0.950
H2ZTJ9_LATCH	HYDIN	ENSLACP00000000720	ENSLACP00000008291	ASH domain-containing protein.	Hydin_ADK domain-containing protein.	0.949
H2ZYG4_LATCH	H2ZTJ9_LATCH	ENSLACP00000002435	ENSLACP00000000720	Uncharacterized protein.	ASH domain-containing protein.	0.949
H2ZYG4_LATCH	H3AN97_LATCH	ENSLACP00000002435	ENSLACP00000011118	Uncharacterized protein.	Uncharacterized protein.	0.951
H2ZYG4_LATCH	HYDIN	ENSLACP00000002435	ENSLACP00000008291	Uncharacterized protein.	Hydin_ADK domain-containing protein.	0.951
H3A2S4_LATCH	H2ZTJ9_LATCH	ENSLACP00000003945	ENSLACP00000000720	Uncharacterized protein.	ASH domain-containing protein.	0.949
H3A2S4_LATCH	H3AN97_LATCH	ENSLACP00000003945	ENSLACP00000011118	Uncharacterized protein.	Uncharacterized protein.	0.933
H3A2S4_LATCH	HYDIN	ENSLACP00000003945	ENSLACP00000008291	Uncharacterized protein.	Hydin_ADK domain-containing protein.	0.951
H3AE15_LATCH	H2ZTJ9_LATCH	ENSLACP00000007886	ENSLACP00000000720	Uncharacterized protein.	ASH domain-containing protein.	0.949
H3AE15_LATCH	H3AN97_LATCH	ENSLACP00000007886	ENSLACP00000011118	Uncharacterized protein.	Uncharacterized protein.	0.951
H3AE15_LATCH	HYDIN	ENSLACP00000007886	ENSLACP00000008291	Uncharacterized protein.	Hydin_ADK domain-containing protein.	0.950
H3AN97_LATCH	H2ZTJ9_LATCH	ENSLACP00000011118	ENSLACP00000000720	Uncharacterized protein.	ASH domain-containing protein.	0.950
H3AN97_LATCH	H2ZYG4_LATCH	ENSLACP00000011118	ENSLACP00000002435	Uncharacterized protein.	Uncharacterized protein.	0.951
H3AN97_LATCH	H3A2S4_LATCH	ENSLACP00000011118	ENSLACP00000003945	Uncharacterized protein.	Uncharacterized protein.	0.933