STRINGSTRING
HNF1A HNF1A LOC102365809 LOC102365809 H3BCU0_LATCH H3BCU0_LATCH FLRT1 FLRT1 EDN1 EDN1 EFNA5 EFNA5 KIF26B KIF26B CYFIP1 CYFIP1 JADE2 JADE2 SPRY1 SPRY1 CTNNB1 CTNNB1 LAMB2 LAMB2 CYFIP2 CYFIP2 DCLK1 DCLK1 TMEM108 TMEM108 ITGA4 ITGA4 SRF SRF EPB41L5 EPB41L5 SSNA1 SSNA1 NRP2 NRP2 PTK7 PTK7 KDM5B KDM5B FGF1 FGF1 H3AY29_LATCH H3AY29_LATCH SPG11 SPG11 RAPH1 RAPH1 STK11 STK11 LOC102356000 LOC102356000 SPAG6 SPAG6 SLIT2 SLIT2 RND2 RND2 H3AM65_LATCH H3AM65_LATCH TNN TNN BIN3 BIN3 MED1 MED1 LOC102362106 LOC102362106 AUTS2 AUTS2 AREG AREG SFRP2 SFRP2 H3AC70_LATCH H3AC70_LATCH EDNRA EDNRA SLIT1 SLIT1 SPART SPART SEMA3F SEMA3F UBAP1 UBAP1 RDH10 RDH10 TGFBR2 TGFBR2 LOC102366847 LOC102366847 C9orf72 C9orf72 LOC102355098 LOC102355098 FLRT3 FLRT3 LLPH LLPH DCX DCX LOC102349535 LOC102349535 IST1 IST1 NRN1 NRN1 ULK2 ULK2 DDR1 DDR1 APP APP RYK RYK EIF2AK4 EIF2AK4 VCL VCL SLIT3 SLIT3 MST1 MST1 LOC102356233 LOC102356233 LOC102366586 LOC102366586 LOC102356247 LOC102356247 IMPACT IMPACT ULK1 ULK1 H3BFZ2_LATCH H3BFZ2_LATCH H3BFW7_LATCH H3BFW7_LATCH TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HNF1AHNF1 homeobox A. (624 aa)
LOC102365809Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
H3BCU0_LATCHLRRNT domain-containing protein. (102 aa)
FLRT1Fibronectin leucine rich transmembrane protein 1. (648 aa)
EDN1Endothelin 1. (216 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (185 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1974 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1259 aa)
JADE2Jade family PHD finger 2. (790 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
CTNNB1Catenin beta 1. (781 aa)
LAMB2Laminin subunit beta 2. (1781 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1255 aa)
DCLK1Doublecortin like kinase 1; Belongs to the protein kinase superfamily. (434 aa)
TMEM108Transmembrane protein 108. (355 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
SRFSerum response factor. (520 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (506 aa)
SSNA1Sjogren syndrome nuclear autoantigen 1. (115 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (929 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
KDM5BLysine demethylase 5B. (1659 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
H3AY29_LATCHUncharacterized protein. (534 aa)
SPG11SPG11 vesicle trafficking associated, spatacsin. (2438 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1312 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
LOC102356000Uncharacterized protein. (211 aa)
SPAG6Sperm associated antigen 6. (477 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
RND2Rho family GTPase 2. (238 aa)
H3AM65_LATCHMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
TNNTenascin N. (831 aa)
BIN3Bridging integrator 3. (253 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
LOC102362106Protein kinase domain-containing protein. (184 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (1021 aa)
AREGAmphiregulin. (235 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
SLIT1Slit guidance ligand 1. (925 aa)
SPARTSpartin. (664 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (772 aa)
UBAP1Ubiquitin associated protein 1. (493 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (348 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
LOC102366847Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
C9orf72C9orf72-SMCR8 complex subunit. (482 aa)
LOC102355098Non-specific serine/threonine protein kinase. (483 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (655 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (126 aa)
DCXUncharacterized protein. (389 aa)
LOC102349535Uncharacterized protein. (176 aa)
IST1IST1 factor associated with ESCRT-III. (260 aa)
NRN1Neuritin 1. (143 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1040 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (964 aa)
APPAmyloid beta precursor protein. (652 aa)
RYKReceptor like tyrosine kinase. (542 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1410 aa)
VCLVinculin. (832 aa)
SLIT3Slit guidance ligand 3. (635 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (707 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
LOC102366586Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)
LOC102356247Uncharacterized protein. (636 aa)
IMPACTImpact RWD domain protein. (319 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1046 aa)
H3BFZ2_LATCHBHLH domain-containing protein. (165 aa)
H3BFW7_LATCHBHLH domain-containing protein. (161 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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