(31 nodes) Regulation of morphogenesis of a branching structure network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	NTN4	Netrin 4. (345 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	H3A2C7_LATCH	Uncharacterized protein. (683 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (798 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	GDNF	Glial cell derived neurotrophic factor. (222 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	SIRT6	Sirtuin 6. (375 aa)
	LOC102357170	Uncharacterized protein. (614 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	FKBPL	FKBP prolyl isomerase like. (269 aa)
	LOC102362405	Homeobox domain-containing protein. (954 aa)
	SIX2	SIX homeobox 2. (289 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	AR	Androgen receptor. (412 aa)
	HOXB7	Homeobox B7. (216 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	SULF1	Sulfatase 1. (1129 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	SIX4	SIX homeobox 4. (742 aa)
	SIX1	SIX homeobox 1. (283 aa)
	MDK	Midkine. (141 aa)
	BTBD7	BTB domain containing 7. (1116 aa)
	AGT	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	TGFB1	ENSLACP00000023240	ENSLACP00000020652	SERPIN domain-containing protein; Belongs to the serpin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.555
AR	CTNNB1	ENSLACP00000017054	ENSLACP00000017209	Androgen receptor.	Catenin beta 1.	0.933
CTNNB1	AR	ENSLACP00000017209	ENSLACP00000017054	Catenin beta 1.	Androgen receptor.	0.933
CTNNB1	SMO	ENSLACP00000017209	ENSLACP00000002758	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.483
CTNNB1	SOX8	ENSLACP00000017209	ENSLACP00000018883	Catenin beta 1.	SRY-box transcription factor 8.	0.701
CTNNB1	TGFB1	ENSLACP00000017209	ENSLACP00000020652	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.540
CTNNB1	WNT2	ENSLACP00000017209	ENSLACP00000017997	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
CTNNB1	WNT2B	ENSLACP00000017209	ENSLACP00000020566	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
FGF7	GDNF	ENSLACP00000016167	ENSLACP00000007058	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glial cell derived neurotrophic factor.	0.431
FGF7	HGF	ENSLACP00000016167	ENSLACP00000023353	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.646
FGF7	TGFB1	ENSLACP00000016167	ENSLACP00000020652	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.556
GDNF	FGF7	ENSLACP00000007058	ENSLACP00000016167	Glial cell derived neurotrophic factor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.431
GDNF	HGF	ENSLACP00000007058	ENSLACP00000023353	Glial cell derived neurotrophic factor.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.449
GDNF	SMO	ENSLACP00000007058	ENSLACP00000002758	Glial cell derived neurotrophic factor.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.543
HGF	FGF7	ENSLACP00000023353	ENSLACP00000016167	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.646
HGF	GDNF	ENSLACP00000023353	ENSLACP00000007058	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Glial cell derived neurotrophic factor.	0.449
HGF	TGFB1	ENSLACP00000023353	ENSLACP00000020652	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.571
SMO	CTNNB1	ENSLACP00000002758	ENSLACP00000017209	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta 1.	0.483
SMO	GDNF	ENSLACP00000002758	ENSLACP00000007058	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Glial cell derived neurotrophic factor.	0.543
SMO	WNT2	ENSLACP00000002758	ENSLACP00000017997	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.477