(47 nodes) Kidney morphogenesis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	COMMD5	COMM domain containing 5. (223 aa)
	IRX1	Iroquois homeobox 1. (460 aa)
	PRKX	Protein kinase X-linked; Belongs to the protein kinase superfamily. (285 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	H3B277_LATCH	Uncharacterized protein. (4290 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	GREB1	Uncharacterized protein. (1948 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	WT1	WT1 transcription factor. (422 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1974 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	HNF1A	HNF1 homeobox A. (624 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	GCNT3	Glucosaminyl (N-acetyl) transferase 3, mucin type. (420 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	H2ZYH3_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	H3A0S5_LATCH	Uncharacterized protein. (547 aa)
	GATA3	GATA binding protein 3. (447 aa)
	PTCH1	Patched 1. (1287 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	PAX8	Paired box 8. (458 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4241 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	TCF21	Transcription factor 21. (179 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	ILK	Integrin linked kinase. (417 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	GDNF	Glial cell derived neurotrophic factor. (222 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1b. (347 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	TMEM59L	Transmembrane protein 59 like. (340 aa)
	GCNT1	Glucosaminyl (N-acetyl) transferase 1. (428 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	H3AFZ6_LATCH	Fraser extracellular matrix complex subunit 1. (1615 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC102350297	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1842 aa)
	GCNT4	Glucosaminyl (N-acetyl) transferase 4. (443 aa)
	IRX3	Iroquois homeobox 3. (447 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP2	GREM1	ENSLACP00000016168	ENSLACP00000007025	Bone morphogenetic protein 2.	Gremlin 1, DAN family BMP antagonist.	0.717
BMP2	LOC102358988	ENSLACP00000016168	ENSLACP00000022115	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.711
BMP2	SMAD4	ENSLACP00000016168	ENSLACP00000009312	Bone morphogenetic protein 2.	MH2 domain-containing protein.	0.711
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
BMP4	GLI3	ENSLACP00000021723	ENSLACP00000004224	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.444
BMP4	GREM1	ENSLACP00000021723	ENSLACP00000007025	Bone morphogenetic protein 4.	Gremlin 1, DAN family BMP antagonist.	0.717
BMP4	LOC102358988	ENSLACP00000021723	ENSLACP00000022115	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.711
BMP4	PTCH1	ENSLACP00000021723	ENSLACP00000004070	Bone morphogenetic protein 4.	Patched 1.	0.605
BMP4	SMAD4	ENSLACP00000021723	ENSLACP00000009312	Bone morphogenetic protein 4.	MH2 domain-containing protein.	0.815
CTNNB1	CTNNBIP1	ENSLACP00000017209	ENSLACP00000007182	Catenin beta 1.	Catenin beta interacting protein 1.	0.999
CTNNB1	FGF8	ENSLACP00000017209	ENSLACP00000007843	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	H2ZYH3_LATCH	ENSLACP00000017209	ENSLACP00000002444	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.573
CTNNB1	ILK	ENSLACP00000017209	ENSLACP00000006792	Catenin beta 1.	Integrin linked kinase.	0.458
CTNNB1	LOC102350297	ENSLACP00000017209	ENSLACP00000021630	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.473
CTNNB1	LOC102358988	ENSLACP00000017209	ENSLACP00000022115	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.627