(17 nodes) Dendritic spine development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAK2	Non-specific serine/threonine protein kinase. (521 aa)
	LOC102363797	Uncharacterized protein. (603 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	LOC102359008	Uncharacterized protein. (1519 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (508 aa)
	EPHB3	EPH receptor B3. (996 aa)
	CDC42	Cell division cycle 42. (156 aa)
	EPHB1	EPH receptor B1. (509 aa)
	EPHB6	EPH receptor B6. (974 aa)
	EPHA10	Uncharacterized protein. (732 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1187 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1849 aa)
	EPHB4	EPH receptor B4. (976 aa)
	LOC102356325	Eph LBD domain-containing protein. (260 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa)
	PAK3	Protein kinase domain-containing protein. (580 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	DOCK10	ENSLACP00000018010	ENSLACP00000019258	Cell division cycle 42.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.953
CDC42	EPHB4	ENSLACP00000018010	ENSLACP00000003330	Cell division cycle 42.	EPH receptor B4.	0.401
CDC42	LOC102363797	ENSLACP00000018010	ENSLACP00000008575	Cell division cycle 42.	Uncharacterized protein.	0.463
CDC42	NCK2	ENSLACP00000018010	ENSLACP00000010412	Cell division cycle 42.	Cytoplasmic protein.	0.705
CDC42	PAK1	ENSLACP00000018010	ENSLACP00000008886	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.995
CDC42	PAK2	ENSLACP00000018010	ENSLACP00000004711	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.986
CDC42	PAK3	ENSLACP00000018010	ENSLACP00000008469	Cell division cycle 42.	Protein kinase domain-containing protein.	0.954
CDC42	SHANK1	ENSLACP00000018010	ENSLACP00000003891	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 1.	0.463
CDC42	SHANK3	ENSLACP00000018010	ENSLACP00000004784	Cell division cycle 42.	SH3 and multiple ankyrin repeat domains 3.	0.480
DOCK10	CDC42	ENSLACP00000019258	ENSLACP00000018010	Dedicator of cytokinesis 10; Belongs to the DOCK family.	Cell division cycle 42.	0.953
EPHA10	NCK2	ENSLACP00000005487	ENSLACP00000010412	Uncharacterized protein.	Cytoplasmic protein.	0.408
EPHB1	LOC102356325	ENSLACP00000018225	ENSLACP00000001578	EPH receptor B1.	Eph LBD domain-containing protein.	0.881
EPHB1	NCK2	ENSLACP00000018225	ENSLACP00000010412	EPH receptor B1.	Cytoplasmic protein.	0.408
EPHB3	NCK2	ENSLACP00000015944	ENSLACP00000010412	EPH receptor B3.	Cytoplasmic protein.	0.408
EPHB4	CDC42	ENSLACP00000003330	ENSLACP00000018010	EPH receptor B4.	Cell division cycle 42.	0.401
EPHB4	NCK2	ENSLACP00000003330	ENSLACP00000010412	EPH receptor B4.	Cytoplasmic protein.	0.408
EPHB6	NCK2	ENSLACP00000006446	ENSLACP00000010412	EPH receptor B6.	Cytoplasmic protein.	0.408
LOC102356325	EPHB1	ENSLACP00000001578	ENSLACP00000018225	Eph LBD domain-containing protein.	EPH receptor B1.	0.881
LOC102356325	NCK2	ENSLACP00000001578	ENSLACP00000010412	Eph LBD domain-containing protein.	Cytoplasmic protein.	0.408
LOC102363797	CDC42	ENSLACP00000008575	ENSLACP00000018010	Uncharacterized protein.	Cell division cycle 42.	0.463