(27 nodes) Positive regulation of cartilage development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	H2ZX66_LATCH	Uncharacterized protein. (641 aa)
	BMP10	Bone morphogenetic protein 10. (405 aa)
	LOC102350164	Uncharacterized protein. (364 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	GDF6	Growth differentiation factor 6a. (408 aa)
	TAPT1	Transmembrane anterior posterior transformation 1. (597 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	GDF5	Growth differentiation factor 5. (501 aa)
	LOC102362376	Protein kinase domain containing, cytoplasmic b. (381 aa)
	BMP6	Bone morphogenetic protein 6. (428 aa)
	LOXL2	Lysyl oxidase like 2. (773 aa)
	H3AVL9_LATCH	Lysyl oxidase-like 3b. (475 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (503 aa)
	GDF2	Growth differentiation factor 2. (431 aa)
	CCN1	Cellular communication network factor 1. (368 aa)
	SOX6	SRY-box transcription factor 6. (814 aa)
	H3BEX6_LATCH	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (420 aa)
	MDK	Midkine. (141 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	SOX5	SRY-box transcription factor 5. (757 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	BMP6	ENSLACP00000002528	ENSLACP00000012388	Bone morphogenetic protein 10.	Bone morphogenetic protein 6.	0.418
BMP10	BMPR2	ENSLACP00000002528	ENSLACP00000017144	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
BMP10	H3BEX6_LATCH	ENSLACP00000002528	ENSLACP00000020447	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.660
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	BMP6	ENSLACP00000016168	ENSLACP00000012388	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.666
BMP2	BMPR2	ENSLACP00000016168	ENSLACP00000017144	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.973
BMP2	FGF18	ENSLACP00000016168	ENSLACP00000015472	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
BMP2	H3BEX6_LATCH	ENSLACP00000016168	ENSLACP00000020447	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.749
BMP2	LOC102356182	ENSLACP00000016168	ENSLACP00000006376	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508
BMP2	SMAD1	ENSLACP00000016168	ENSLACP00000012771	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.739
BMP2	SMAD7	ENSLACP00000016168	ENSLACP00000006551	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.617
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
BMP4	BMP6	ENSLACP00000021723	ENSLACP00000012388	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.671
BMP4	BMPR2	ENSLACP00000021723	ENSLACP00000017144	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.973
BMP4	FGF18	ENSLACP00000021723	ENSLACP00000015472	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
BMP4	GDF5	ENSLACP00000021723	ENSLACP00000010602	Bone morphogenetic protein 4.	Growth differentiation factor 5.	0.432
BMP4	GLI3	ENSLACP00000021723	ENSLACP00000004224	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.444
BMP4	H3BEX6_LATCH	ENSLACP00000021723	ENSLACP00000020447	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.749
BMP4	LOC102356182	ENSLACP00000021723	ENSLACP00000006376	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
BMP4	SMAD1	ENSLACP00000021723	ENSLACP00000012771	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.745