(67 nodes) Regulation of wound healing network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	LOC102358653	Tetraspanin. (149 aa)
	C1QTNF6	C1q and TNF related 6. (273 aa)
	LOC102356587	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (628 aa)
	H2ZZQ4_LATCH	LRRCT domain-containing protein. (200 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	LOC102348856	Uncharacterized protein. (190 aa)
	DUOX2	Dual oxidase 2. (1551 aa)
	H3A3Z8_LATCH	SERPIN domain-containing protein; Belongs to the serpin family. (332 aa)
	LOC102348536	Uncharacterized protein. (184 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (403 aa)
	CLASP2	Cytoplasmic linker associated protein 2. (1303 aa)
	ANO6	Anoctamin. (766 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	CPB2	Carboxypeptidase B2. (426 aa)
	HBEGF	Heparin binding EGF like growth factor. (209 aa)
	FGG	Fibrinogen gamma chain. (376 aa)
	MYOZ1	Myozenin 1. (313 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	ARFGEF1	ADP ribosylation factor guanine nucleotide exchange factor 1. (1801 aa)
	FGB	Fibrinogen beta chain. (454 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	LOC102358409	Uncharacterized protein. (534 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	LOC102346566	Annexin. (343 aa)
	RREB1	Ras responsive element binding protein 1. (1516 aa)
	PLAU	Uncharacterized protein. (469 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (692 aa)
	MMRN1	Multimerin 1. (914 aa)
	PHLDB2	Pleckstrin homology like domain family B member 2. (536 aa)
	CRK	CRK proto-oncogene, adaptor protein. (310 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	LOC102362746	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	SH2B3	SH2B adaptor protein 3. (583 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	PROS1	Protein S. (677 aa)
	CADM4	Cell adhesion molecule 4. (380 aa)
	TBXA2R	Thromboxane A2 receptor. (351 aa)
	ENPP4	Ectonucleotide pyrophosphatase/phosphodiesterase 4. (456 aa)
	CLDN1	Claudin 1. (210 aa)
	LOC102353191	Si:ch211-237i5.4. (346 aa)
	SERPINC1	Serpin family C member 1; Belongs to the serpin family. (485 aa)
	FERMT1	Fermitin family member 1. (684 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	C1QTNF1	C1q and TNF related 1. (229 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1591 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	H3BEF8_LATCH	Cytoplasmic linker associated protein 1a. (1413 aa)
	H3BEP8_LATCH	Uncharacterized protein. (556 aa)
	H3BES4_LATCH	Uncharacterized protein. (558 aa)
	CLDN19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
	CD34	Uncharacterized protein. (378 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (607 aa)
	FERMT2	Fermitin family member 2. (552 aa)
	AJAP1	Adherens junctions associated protein 1. (136 aa)
	CLASP1	Uncharacterized protein. (66 aa)
	APOH	Apolipoprotein H. (351 aa)
	HPSE	Heparanase. (544 aa)
	ADTRP	Uncharacterized protein. (229 aa)
	PLG	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	VEGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (148 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOH	F2	ENSLACP00000022592	ENSLACP00000021404	Apolipoprotein H.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.891
APOH	FGB	ENSLACP00000022592	ENSLACP00000008521	Apolipoprotein H.	Fibrinogen beta chain.	0.646
APOH	FGG	ENSLACP00000022592	ENSLACP00000007010	Apolipoprotein H.	Fibrinogen gamma chain.	0.817
APOH	H2ZZQ4_LATCH	ENSLACP00000022592	ENSLACP00000002875	Apolipoprotein H.	LRRCT domain-containing protein.	0.541
APOH	LOC102346566	ENSLACP00000022592	ENSLACP00000010172	Apolipoprotein H.	Annexin.	0.452
APOH	LOC102353191	ENSLACP00000022592	ENSLACP00000018039	Apolipoprotein H.	Si:ch211-237i5.4.	0.418
APOH	LOC102356587	ENSLACP00000022592	ENSLACP00000002593	Apolipoprotein H.	Uncharacterized protein; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.709
APOH	LOC102358409	ENSLACP00000022592	ENSLACP00000009670	Apolipoprotein H.	Uncharacterized protein.	0.620
APOH	PLG	ENSLACP00000022592	ENSLACP00000023309	Apolipoprotein H.	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.709
APOH	SERPINC1	ENSLACP00000022592	ENSLACP00000018195	Apolipoprotein H.	Serpin family C member 1; Belongs to the serpin family.	0.838
APOH	SERPINF2	ENSLACP00000022592	ENSLACP00000003724	Apolipoprotein H.	Serpin family F member 2; Belongs to the serpin family.	0.667
CADM4	CLASP2	ENSLACP00000017006	ENSLACP00000005846	Cell adhesion molecule 4.	Cytoplasmic linker associated protein 2.	0.668
CD34	LOC102358653	ENSLACP00000021425	ENSLACP00000001327	Uncharacterized protein.	Tetraspanin.	0.440
CD34	LTA	ENSLACP00000021425	ENSLACP00000007765	Uncharacterized protein.	Lymphotoxin alpha.	0.400
CLASP2	CADM4	ENSLACP00000005846	ENSLACP00000017006	Cytoplasmic linker associated protein 2.	Cell adhesion molecule 4.	0.668
CLASP2	PHLDB2	ENSLACP00000005846	ENSLACP00000011883	Cytoplasmic linker associated protein 2.	Pleckstrin homology like domain family B member 2.	0.563
CLDN1	CLDN19	ENSLACP00000017569	ENSLACP00000020552	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.671
CLDN1	LOC102348536	ENSLACP00000017569	ENSLACP00000004957	Claudin 1.	Uncharacterized protein.	0.774
CLDN1	LOC102348856	ENSLACP00000017569	ENSLACP00000004079	Claudin 1.	Uncharacterized protein.	0.775
CLDN1	LOC102358653	ENSLACP00000017569	ENSLACP00000001327	Claudin 1.	Tetraspanin.	0.438