(54 nodes) Neural precursor cell proliferation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NUMB	NUMB endocytic adaptor protein. (659 aa)
	LOC102352831	KA1 domain-containing protein. (403 aa)
	RYK	Receptor like tyrosine kinase. (542 aa)
	LOC102366946	Uncharacterized protein. (358 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	BTG2	BTG anti-proliferation factor 2. (149 aa)
	HOOK3	Hook microtubule tethering protein 3. (709 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	NDUFS2	NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (466 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1187 aa)
	H3A6Z7_LATCH	Bardet-Biedl syndrome 1. (596 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	GBX2	Gastrulation brain homeobox 2. (344 aa)
	KIFAP3	Kinesin associated protein 3. (795 aa)
	ACSL6	Uncharacterized protein. (749 aa)
	RPGRIP1	RPGR interacting protein 1. (1244 aa)
	LOC102360373	Fork-head domain-containing protein. (374 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (502 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	H3AES2_LATCH	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (354 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1027 aa)
	ORC3	Origin recognition complex subunit 3. (720 aa)
	LOC102345131	Si:ch1073-416j23.1. (581 aa)
	ZZEF1	Zinc finger ZZ-type and EF-hand domain containing 1. (2945 aa)
	ATF5	Activating transcription factor 5. (340 aa)
	CEP120	Centrosomal protein 120. (499 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1644 aa)
	LOC102357614	Fork-head domain-containing protein. (345 aa)
	DCT	Dopachrome tautomerase. (521 aa)
	MELK	Maternal embryonic leucine zipper kinase; Belongs to the protein kinase superfamily. (250 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
	ARX	Aristaless related homeobox. (455 aa)
	FOXG1	Forkhead box G1. (409 aa)
	DAGLB	Diacylglycerol lipase beta. (674 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	HHIP	Hedgehog interacting protein. (687 aa)
	DBN1	Drebrin 1. (684 aa)
	H3B5C9_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	PAX6	Paired box 6. (463 aa)
	OTP	Orthopedia homeobox. (333 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (477 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	DAGLA	Uncharacterized protein. (147 aa)
	NF1	Neurofibromin 1. (2814 aa)
	RACGAP1	Rac GTPase activating protein 1. (635 aa)
	IFT20	Intraflagellar transport 20. (132 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	DIXDC1	DIX domain containing 1. (695 aa)
	NUMBL	NUMB like endocytic adaptor protein. (590 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	SOX5	SRY-box transcription factor 5. (757 aa)
	PCM1	Pericentriolar material 1. (2154 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL6	TP53	ENSLACP00000006581	ENSLACP00000015915	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.696
BTG2	TP53	ENSLACP00000002927	ENSLACP00000015915	BTG anti-proliferation factor 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.510
CEP120	LOC102366946	ENSLACP00000010056	ENSLACP00000001955	Centrosomal protein 120.	Uncharacterized protein.	0.935
DAGLA	DAGLB	ENSLACP00000018134	ENSLACP00000015458	Uncharacterized protein.	Diacylglycerol lipase beta.	0.943
DAGLB	DAGLA	ENSLACP00000015458	ENSLACP00000018134	Diacylglycerol lipase beta.	Uncharacterized protein.	0.943
DCT	DRD2	ENSLACP00000011443	ENSLACP00000020922	Dopachrome tautomerase.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.424
DRD2	DCT	ENSLACP00000020922	ENSLACP00000011443	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Dopachrome tautomerase.	0.424
FGF8	FOXG1	ENSLACP00000007843	ENSLACP00000014746	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Forkhead box G1.	0.408
FGF8	FRS2	ENSLACP00000007843	ENSLACP00000007102	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor substrate 2.	0.649
FGF8	GBX2	ENSLACP00000007843	ENSLACP00000006134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Gastrulation brain homeobox 2.	0.737
FGF8	GLI3	ENSLACP00000007843	ENSLACP00000004224	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.634
FGF8	LEF1	ENSLACP00000007843	ENSLACP00000005598	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Lymphoid enhancer binding factor 1.	0.486
FGF8	PAX6	ENSLACP00000007843	ENSLACP00000017411	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box 6.	0.691
FGF8	SMO	ENSLACP00000007843	ENSLACP00000002758	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.534
FGF8	WNT1	ENSLACP00000007843	ENSLACP00000021628	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.716
FOXG1	FGF8	ENSLACP00000014746	ENSLACP00000007843	Forkhead box G1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
FOXG1	LOC102360373	ENSLACP00000014746	ENSLACP00000006831	Forkhead box G1.	Fork-head domain-containing protein.	0.902
FOXG1	OTP	ENSLACP00000014746	ENSLACP00000017670	Forkhead box G1.	Orthopedia homeobox.	0.491
FOXG1	PAX6	ENSLACP00000014746	ENSLACP00000017411	Forkhead box G1.	Paired box 6.	0.614
FRS2	FGF8	ENSLACP00000007102	ENSLACP00000007843	Fibroblast growth factor receptor substrate 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.649