(11 nodes) Secondary palate development network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (675 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (637 aa)
	H3A3Z5_LATCH	Uncharacterized protein. (679 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	H3AWB3_LATCH	Uncharacterized protein. (560 aa)
	H3AXS1_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ITGB6	ITGB8	ENSLACP00000000457	ENSLACP00000001378	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.766
ITGB8	ITGB6	ENSLACP00000001378	ENSLACP00000000457	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.766
LEF1	LOC102358988	ENSLACP00000005598	ENSLACP00000022115	Lymphoid enhancer binding factor 1.	Mothers against decapentaplegic homolog.	0.957
LEF1	SMAD4	ENSLACP00000005598	ENSLACP00000009312	Lymphoid enhancer binding factor 1.	MH2 domain-containing protein.	0.957
LOC102358988	LEF1	ENSLACP00000022115	ENSLACP00000005598	Mothers against decapentaplegic homolog.	Lymphoid enhancer binding factor 1.	0.957
LOC102358988	SMAD4	ENSLACP00000022115	ENSLACP00000009312	Mothers against decapentaplegic homolog.	MH2 domain-containing protein.	0.901
LOC102358988	TGFBR2	ENSLACP00000022115	ENSLACP00000004468	Mothers against decapentaplegic homolog.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.752
SMAD4	LEF1	ENSLACP00000009312	ENSLACP00000005598	MH2 domain-containing protein.	Lymphoid enhancer binding factor 1.	0.957
SMAD4	LOC102358988	ENSLACP00000009312	ENSLACP00000022115	MH2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.901
SMAD4	TGFBR2	ENSLACP00000009312	ENSLACP00000004468	MH2 domain-containing protein.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.863
TGFBR2	LOC102358988	ENSLACP00000004468	ENSLACP00000022115	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	Mothers against decapentaplegic homolog.	0.752
TGFBR2	SMAD4	ENSLACP00000004468	ENSLACP00000009312	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	MH2 domain-containing protein.	0.863