(84 nodes) Positive regulation of small molecule metabolic process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3B6H7_LATCH	Dimer_Tnp_hAT domain-containing protein. (246 aa)
	H3B749_LATCH	Uncharacterized protein. (360 aa)
	H3BBU7_LATCH	Uncharacterized protein. (127 aa)
	GUCA1C	Guanylate cyclase activator 1C. (191 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	CLYBL	Citrate lyase beta like. (341 aa)
	CD74	CD74 molecule. (279 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (396 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (749 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (469 aa)
	STARD4	StAR related lipid transfer domain containing 4. (216 aa)
	H2ZVZ2_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (340 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	H2ZWP1_LATCH	Dimer_Tnp_hAT domain-containing protein. (525 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
	H2ZXA8_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (339 aa)
	H2ZY15_LATCH	Uncharacterized protein. (481 aa)
	H2ZYP2_LATCH	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	H2ZZS8_LATCH	Uncharacterized protein. (346 aa)
	H3A0C4_LATCH	Uncharacterized protein. (204 aa)
	H3A113_LATCH	Dimer_Tnp_hAT domain-containing protein. (167 aa)
	SCAP	SREBF chaperone. (1283 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (649 aa)
	H3A536_LATCH	Uncharacterized protein. (167 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	LOC102350947	G_PROTEIN_RECEP_F1_2 domain-containing protein. (327 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1083 aa)
	H3A6C6_LATCH	Dimer_Tnp_hAT domain-containing protein. (210 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (217 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (375 aa)
	MLXIPL	MLX interacting protein like. (862 aa)
	GUCA1B	Uncharacterized protein. (197 aa)
	H3BGZ2_LATCH	Uncharacterized protein. (176 aa)
	H3BFB7_LATCH	Uncharacterized protein. (489 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (653 aa)
	H3BE69_LATCH	PID domain-containing protein. (136 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (456 aa)
	DDB1	Damage specific DNA binding protein 1. (1142 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (743 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	PODN	Podocan. (621 aa)
	SLC45A3	Solute carrier family 45 member 3. (563 aa)
	ZBTB20	Zinc finger and BTB domain containing 20. (619 aa)
	NCS1	Uncharacterized protein. (181 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa)
	GUCA1A	Guanylate cyclase activator 1A. (202 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	H3AFG3_LATCH	Dimer_Tnp_hAT domain-containing protein. (202 aa)
	H3AFH7_LATCH	Uncharacterized protein. (364 aa)
	H3AFI1_LATCH	Uncharacterized protein. (241 aa)
	BEND3	BEN domain containing 3. (842 aa)
	SIRT1	Sirtuin 1. (729 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (620 aa)
	LOC102346566	Annexin. (343 aa)
	PRXL2C	Peroxiredoxin like 2C. (206 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	H3APJ3_LATCH	Dimer_Tnp_hAT domain-containing protein. (226 aa)
	H3ARI5_LATCH	Uncharacterized protein. (417 aa)
	BMP6	Bone morphogenetic protein 6. (428 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	H3ASZ0_LATCH	Uncharacterized protein. (205 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	H3AV95_LATCH	DUF4371 domain-containing protein. (559 aa)
	MLYCD	Malonyl-CoA decarboxylase. (480 aa)
	H3AWY0_LATCH	Uncharacterized protein. (559 aa)
	DAB2	DAB adaptor protein 2. (745 aa)
	H3AZ56_LATCH	Dimer_Tnp_hAT domain-containing protein. (458 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1100 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	MAS1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	PODNL1	Podocan like 1. (599 aa)
	MID1IP1	MID1 interacting protein 1. (159 aa)
	APOA4	Apolipoprotein A4. (367 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (426 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	ENSLACP00000001162	ENSLACP00000005686	ATP binding cassette subfamily D member 1.	ATP binding cassette subfamily D member 2.	0.901
ABCD2	ABCD1	ENSLACP00000005686	ENSLACP00000001162	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 1.	0.901
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	PPARA	ENSLACP00000000452	ENSLACP00000012397	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.654
ADIPOQ	PPARG	ENSLACP00000000452	ENSLACP00000010456	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.829
ADIPOQ	PPARGC1A	ENSLACP00000000452	ENSLACP00000015962	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.604
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
APP	CD74	ENSLACP00000001643	ENSLACP00000018188	Amyloid beta precursor protein.	CD74 molecule.	0.700
APP	LOC102346566	ENSLACP00000001643	ENSLACP00000010172	Amyloid beta precursor protein.	Annexin.	0.593
APP	PSEN1	ENSLACP00000001643	ENSLACP00000012775	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
CD74	APP	ENSLACP00000018188	ENSLACP00000001643	CD74 molecule.	Amyloid beta precursor protein.	0.700
DDB1	KAT2B	ENSLACP00000020033	ENSLACP00000007242	Damage specific DNA binding protein 1.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.439
DDB1	SIRT1	ENSLACP00000020033	ENSLACP00000009079	Damage specific DNA binding protein 1.	Sirtuin 1.	0.411
GUCA1A	GUCA1B	ENSLACP00000007638	ENSLACP00000021167	Guanylate cyclase activator 1A.	Uncharacterized protein.	0.769
GUCA1A	GUCA1C	ENSLACP00000007638	ENSLACP00000019179	Guanylate cyclase activator 1A.	Guanylate cyclase activator 1C.	0.608
GUCA1B	GUCA1A	ENSLACP00000021167	ENSLACP00000007638	Uncharacterized protein.	Guanylate cyclase activator 1A.	0.769
GUCA1B	GUCA1C	ENSLACP00000021167	ENSLACP00000019179	Uncharacterized protein.	Guanylate cyclase activator 1C.	0.939
GUCA1C	GUCA1A	ENSLACP00000019179	ENSLACP00000007638	Guanylate cyclase activator 1C.	Guanylate cyclase activator 1A.	0.608
GUCA1C	GUCA1B	ENSLACP00000019179	ENSLACP00000021167	Guanylate cyclase activator 1C.	Uncharacterized protein.	0.939
H2ZZS8_LATCH	H3A0C4_LATCH	ENSLACP00000002899	ENSLACP00000003095	Uncharacterized protein.	Uncharacterized protein.	0.486