(49 nodes) Negative regulation of small molecule metabolic process network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	LOC102352539	Uncharacterized protein. (949 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	FAM3A	Family with sequence similarity 3 member A. (227 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	SNAI2	Snail family zinc finger 2. (268 aa)
	TRIB3	Tribbles pseudokinase 3. (353 aa)
	BRCA1	BRCA1 DNA repair associated. (1873 aa)
	FAM3C	Family with sequence similarity 3 member C. (134 aa)
	LEPR	Leptin receptor. (1149 aa)
	SIRT6	Sirtuin 6. (375 aa)
	CRY1	Cryptochrome circadian regulator 1. (653 aa)
	ERLIN1	ER lipid raft associated 1. (328 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (644 aa)
	FLCN	Folliculin. (576 aa)
	SIRT1	Sirtuin 1. (729 aa)
	H3AP48_LATCH	Dickkopf_N domain-containing protein. (253 aa)
	ERLIN2	ER lipid raft associated 2. (338 aa)
	LOC102365364	Cryptochrome circadian regulator 3a. (616 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
	ATCAY	ATCAY kinesin light chain interacting caytaxin. (676 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1233 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	H3AWN2_LATCH	Cryptochrome circadian regulator 4. (531 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (508 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (197 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (549 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (222 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (646 aa)
	PLEK	Pleckstrin. (353 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	TSPO	Translocator protein. (164 aa)
	SLC27A4	Solute carrier family 27 member 4. (654 aa)
	DDIT4	DNA damage inducible transcript 4. (222 aa)
	SNAI1	Snail family transcriptional repressor 1. (257 aa)
	PDZD3	PDZ domain containing 3. (459 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (212 aa)
	SIRT4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
	SOGA1	Suppressor of glucose, autophagy associated 1. (1651 aa)
	C1QTNF12	C1q and TNF related 12. (265 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (217 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (145 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (707 aa)
	LOC102367579	Translocator protein 2. (163 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL2	ENSLACP00000000452	ENSLACP00000000307	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
ADIPOQ	LEPR	ENSLACP00000000452	ENSLACP00000008593	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.554
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	PPARA	ENSLACP00000000452	ENSLACP00000012397	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.654
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
APPL2	ADIPOQ	ENSLACP00000000307	ENSLACP00000000452	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.554
APPL2	C1QTNF9	ENSLACP00000000307	ENSLACP00000014983	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.554
APPL2	LOC102346019	ENSLACP00000000307	ENSLACP00000019134	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	C1q domain-containing protein.	0.554
APPL2	PLEK	ENSLACP00000000307	ENSLACP00000018332	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Pleckstrin.	0.420
BRCA1	LOC102352539	ENSLACP00000006740	ENSLACP00000009233	BRCA1 DNA repair associated.	Uncharacterized protein.	0.814
BRCA1	PARP1	ENSLACP00000006740	ENSLACP00000003056	BRCA1 DNA repair associated.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.745
BRCA1	STAT3	ENSLACP00000006740	ENSLACP00000013656	BRCA1 DNA repair associated.	Signal transducer and activator of transcription.	0.507
BRCA1	TP53	ENSLACP00000006740	ENSLACP00000015915	BRCA1 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.973
C1QTNF9	APPL2	ENSLACP00000014983	ENSLACP00000000307	C1q domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
CRY1	LOC102367579	ENSLACP00000009266	ENSLACP00000023211	Cryptochrome circadian regulator 1.	Translocator protein 2.	0.490
CRY1	TSPO	ENSLACP00000009266	ENSLACP00000019334	Cryptochrome circadian regulator 1.	Translocator protein.	0.490
DDIT4	LOC102352539	ENSLACP00000019932	ENSLACP00000009233	DNA damage inducible transcript 4.	Uncharacterized protein.	0.554
DDIT4	TP53	ENSLACP00000019932	ENSLACP00000015915	DNA damage inducible transcript 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.633
H3AWN2_LATCH	LOC102367579	ENSLACP00000014053	ENSLACP00000023211	Cryptochrome circadian regulator 4.	Translocator protein 2.	0.490
H3AWN2_LATCH	TSPO	ENSLACP00000014053	ENSLACP00000019334	Cryptochrome circadian regulator 4.	Translocator protein.	0.490