(20 nodes) Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	BAG6	BCL2 associated athanogene 6. (995 aa)
	ATF4	Activating transcription factor 4. (374 aa)
	QRICH1	Glutamine rich 1. (779 aa)
	TRIB3	Tribbles pseudokinase 3. (353 aa)
	BAX	Uncharacterized protein. (223 aa)
	SELENOK	Selenoprotein K. (91 aa)
	LOC102359041	Zgc:153993. (208 aa)
	ERN2	Endoplasmic reticulum to nucleus signaling 2. (974 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (223 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1202 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (956 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	TMEM117	Transmembrane protein 117. (514 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (257 aa)
	LOC102367479	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (992 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (396 aa)
	DDIT3	DNA damage inducible transcript 3. (256 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	APAF1	ENSLACP00000001333	ENSLACP00000014568	Apoptosis inducing factor mitochondria associated 1.	Apoptotic peptidase activating factor 1.	0.551
AIFM1	BAX	ENSLACP00000001333	ENSLACP00000007049	Apoptosis inducing factor mitochondria associated 1.	Uncharacterized protein.	0.922
AIFM1	LOC102359041	ENSLACP00000001333	ENSLACP00000012675	Apoptosis inducing factor mitochondria associated 1.	Zgc:153993.	0.926
APAF1	AIFM1	ENSLACP00000014568	ENSLACP00000001333	Apoptotic peptidase activating factor 1.	Apoptosis inducing factor mitochondria associated 1.	0.551
APAF1	BAK1	ENSLACP00000014568	ENSLACP00000018296	Apoptotic peptidase activating factor 1.	BCL2 antagonist/killer 1.	0.670
APAF1	BAX	ENSLACP00000014568	ENSLACP00000007049	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.800
APAF1	LOC102359041	ENSLACP00000014568	ENSLACP00000012675	Apoptotic peptidase activating factor 1.	Zgc:153993.	0.670
APAF1	TP53	ENSLACP00000014568	ENSLACP00000015915	Apoptotic peptidase activating factor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.790
ATF4	CEBPB	ENSLACP00000004433	ENSLACP00000002325	Activating transcription factor 4.	CCAAT/enhancer-binding protein.	0.965
ATF4	CHAC1	ENSLACP00000004433	ENSLACP00000013183	Activating transcription factor 4.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.784
ATF4	DDIT3	ENSLACP00000004433	ENSLACP00000021463	Activating transcription factor 4.	DNA damage inducible transcript 3.	0.987
ATF4	ERN1	ENSLACP00000004433	ENSLACP00000018252	Activating transcription factor 4.	Endoplasmic reticulum to nucleus signaling 1.	0.420
ATF4	ERN2	ENSLACP00000004433	ENSLACP00000013101	Activating transcription factor 4.	Endoplasmic reticulum to nucleus signaling 2.	0.420
ATF4	TRIB3	ENSLACP00000004433	ENSLACP00000006545	Activating transcription factor 4.	Tribbles pseudokinase 3.	0.843
BAK1	APAF1	ENSLACP00000018296	ENSLACP00000014568	BCL2 antagonist/killer 1.	Apoptotic peptidase activating factor 1.	0.670
BAK1	BAX	ENSLACP00000018296	ENSLACP00000007049	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.985
BAK1	LOC102359041	ENSLACP00000018296	ENSLACP00000012675	BCL2 antagonist/killer 1.	Zgc:153993.	0.900
BAK1	TP53	ENSLACP00000018296	ENSLACP00000015915	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.787
BAX	AIFM1	ENSLACP00000007049	ENSLACP00000001333	Uncharacterized protein.	Apoptosis inducing factor mitochondria associated 1.	0.922
BAX	APAF1	ENSLACP00000007049	ENSLACP00000014568	Uncharacterized protein.	Apoptotic peptidase activating factor 1.	0.800