(72 nodes) Extracellular exosome network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAX	Uncharacterized protein. (223 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (614 aa)
	LAMP2	Lysosomal associated membrane protein 2. (416 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	H3A8I2_LATCH	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (480 aa)
	FN1	Fibronectin 1. (2295 aa)
	LOC102346516	Uncharacterized protein. (194 aa)
	SLC26A4	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (771 aa)
	HBS1L	HBS1 like translational GTPase. (490 aa)
	SMS	Spermine synthase. (311 aa)
	SCRN2	Secernin 2. (425 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4241 aa)
	ARMC3	Armadillo repeat containing 3. (589 aa)
	BAG6	BCL2 associated athanogene 6. (995 aa)
	BEND7	BEN domain-containing protein. (417 aa)
	PEPD	Peptidase D; Belongs to the peptidase M24B family. (261 aa)
	GARS1	Glycyl-tRNA synthetase. (520 aa)
	H2ZVK6_LATCH	Uncharacterized protein; Belongs to the argonaute family. (861 aa)
	LOC102358653	Tetraspanin. (149 aa)
	TSTA3	Tissue specific transplantation antigen P35B. (271 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	H2ZTL8_LATCH	HBS1_N domain-containing protein. (568 aa)
	H2ZSU9_LATCH	Uncharacterized protein. (1477 aa)
	LOC102351466	Uncharacterized protein. (201 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
	GMDS	GDP-mannose 4,6-dehydratase. (150 aa)
	PLAA	Phospholipase A2 activating protein. (470 aa)
	S100Z	Protein S100; Belongs to the S-100 family. (123 aa)
	GPRC5B	G protein-coupled receptor class C group 5 member B. (415 aa)
	GOLGA4	Golgin A4. (2330 aa)
	LOC102358889	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (114 aa)
	PDCD6IP	Programmed cell death 6 interacting protein. (732 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (783 aa)
	SLC12A3	Solute carrier family 12 member 3. (1040 aa)
	TSG101	Tumor susceptibility 101. (392 aa)
	MYOC	Myocilin. (272 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	LOC102346566	Annexin. (343 aa)
	ACY1	Aminoacylase 1. (428 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1923 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1016 aa)
	H3B090_LATCH	DUF4455 domain-containing protein. (1071 aa)
	CCDC180	DUF4456 domain-containing protein. (263 aa)
	H3B277_LATCH	Uncharacterized protein. (4290 aa)
	C8A	Complement C8 alpha chain. (581 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
	PKHD1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2690 aa)
	HGD	Homogentisate 1,2-dioxygenase. (459 aa)
	FASLG	Fas ligand. (261 aa)
	LOC102365742	Ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (169 aa)
	H3B8Z6_LATCH	SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (99 aa)
	LOC102360278	Uncharacterized protein. (1069 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (672 aa)
	NAGK	N-acetylglucosamine kinase. (284 aa)
	GPRC5C	G protein-coupled receptor, class C, group 5, member C. (422 aa)
	PLEKHA7	Pleckstrin homology domain containing A7. (1138 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (776 aa)
	ARHGAP23	Rho GTPase activating protein 23. (1813 aa)
	YBX1	Y-box binding protein 1. (305 aa)
	UBE2G1	Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	C8G	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
	FETUB	Fetuin B. (486 aa)
	CPVL	Carboxypeptidase vitellogenic like; Belongs to the peptidase S10 family. (480 aa)
	FAH	Fumarylacetoacetase. (348 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (157 aa)
	SLC12A2	Solute carrier family 12 member 2. (1179 aa)
	UFC1	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (169 aa)
	TAX1BP1	Tax1 binding protein 1. (831 aa)
	SLC12A1	Solute carrier family 12 member 1. (1102 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	PTER	Phosphotriesterase related. (349 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C8A	C8G	ENSLACP00000016041	ENSLACP00000022686	Complement C8 alpha chain.	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	0.996
C8G	C8A	ENSLACP00000022686	ENSLACP00000016041	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	Complement C8 alpha chain.	0.996
CCDC180	H3B090_LATCH	ENSLACP00000015957	ENSLACP00000015311	DUF4456 domain-containing protein.	DUF4455 domain-containing protein.	0.948
DICER1	H2ZVK6_LATCH	ENSLACP00000009412	ENSLACP00000001427	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	Uncharacterized protein; Belongs to the argonaute family.	0.985
FAH	HGD	ENSLACP00000009155	ENSLACP00000017066	Fumarylacetoacetase.	Homogentisate 1,2-dioxygenase.	0.943
GMDS	TSTA3	ENSLACP00000013025	ENSLACP00000001235	GDP-mannose 4,6-dehydratase.	Tissue specific transplantation antigen P35B.	0.986
H2ZVK6_LATCH	DICER1	ENSLACP00000001427	ENSLACP00000009412	Uncharacterized protein; Belongs to the argonaute family.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.985
H2ZVK6_LATCH	YBX1	ENSLACP00000001427	ENSLACP00000020639	Uncharacterized protein; Belongs to the argonaute family.	Y-box binding protein 1.	0.625
H3B090_LATCH	CCDC180	ENSLACP00000015311	ENSLACP00000015957	DUF4455 domain-containing protein.	DUF4456 domain-containing protein.	0.948
H3B277_LATCH	PKHD1	ENSLACP00000015998	ENSLACP00000016644	Uncharacterized protein.	PKHD1 ciliary IPT domain containing fibrocystin/polyductin.	0.487
HGD	FAH	ENSLACP00000017066	ENSLACP00000009155	Homogentisate 1,2-dioxygenase.	Fumarylacetoacetase.	0.943
HSPA4	LAMP2	ENSLACP00000011701	ENSLACP00000006330	Heat shock protein family A (Hsp70) member 4.	Lysosomal associated membrane protein 2.	0.462
HSPA4	LOC102358653	ENSLACP00000011701	ENSLACP00000001327	Heat shock protein family A (Hsp70) member 4.	Tetraspanin.	0.613
HSPA4	TSG101	ENSLACP00000011701	ENSLACP00000011613	Heat shock protein family A (Hsp70) member 4.	Tumor susceptibility 101.	0.612
ITGA4	LOC102358653	ENSLACP00000016373	ENSLACP00000001327	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	Tetraspanin.	0.463
LAMP2	HSPA4	ENSLACP00000006330	ENSLACP00000011701	Lysosomal associated membrane protein 2.	Heat shock protein family A (Hsp70) member 4.	0.462
LOC102346516	YBX1	ENSLACP00000005509	ENSLACP00000020639	Uncharacterized protein.	Y-box binding protein 1.	0.588
LOC102346566	LOC102358653	ENSLACP00000010172	ENSLACP00000001327	Annexin.	Tetraspanin.	0.545
LOC102346566	S100Z	ENSLACP00000010172	ENSLACP00000012564	Annexin.	Protein S100; Belongs to the S-100 family.	0.552
LOC102346566	TSG101	ENSLACP00000010172	ENSLACP00000011613	Annexin.	Tumor susceptibility 101.	0.558