(92 nodes) Positive regulation of ERK1 and ERK2 cascade network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	CCN2	Cellular communication network factor 2. (344 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (635 aa)
	FGFR3	Fibroblast growth factor receptor. (778 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (469 aa)
	LOC102364341	Uncharacterized protein. (271 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (474 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	GLIPR2	GLI pathogenesis related 2; Belongs to the CRISP family. (153 aa)
	GAREM1	GRB2 associated regulator of MAPK1 subtype 1. (883 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	RAMP3	Receptor activity modifying protein 3. (117 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	H2ZZY5_LATCH	Uncharacterized protein. (548 aa)
	OPRD1	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC102366847	Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (210 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	PHB	Prohibitin. (272 aa)
	FGG	Fibrinogen gamma chain. (376 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (586 aa)
	AKAP12	A-kinase anchoring protein 12. (1381 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	FGB	Fibrinogen beta chain. (454 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	TNFAIP8L3	TNF alpha induced protein 8 like 3. (187 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	PRXL2C	Peroxiredoxin like 2C. (206 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1514 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	TEK	TEK receptor tyrosine kinase. (914 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	GAREM2	GRB2 associated regulator of MAPK1 subtype 2. (809 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	NOX4	NADPH oxidase 4. (541 aa)
	H3ASC2_LATCH	Solute carrier family 30 member 10. (464 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	LOC102354453	Uncharacterized protein. (230 aa)
	H3ATX3_LATCH	Uncharacterized protein. (199 aa)
	FBXW9	F-box and WD repeat domain containing 9. (465 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	DSTYK	Dual serine/threonine and tyrosine protein kinase. (848 aa)
	GPNMB	Glycoprotein nmb. (607 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	DNAJC27	DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (439 aa)
	PRR5	Uncharacterized protein. (599 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	GAS6	Uncharacterized protein. (681 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	PDGFRB	Platelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1103 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	CD74	CD74 molecule. (279 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	NPTN	Neuroplastin. (346 aa)
	H3BA69_LATCH	Si:ch73-330k17.3. (196 aa)
	CIB1	Calcium and integrin binding 1. (190 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (199 aa)
	MARCO	SRCR domain-containing protein. (444 aa)
	LOC102365809	Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (249 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC102352712	Protein tyrosine phosphatase non-receptor type 11b. (553 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	FGFR4	Fibroblast growth factor receptor. (810 aa)
	LOC102352351	C-C motif chemokine. (88 aa)
	FBXW7	F-box and WD repeat domain containing 7. (713 aa)
	BMPER	BMP binding endothelial regulator. (682 aa)
	LOC102366586	Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL1	CRKL	ENSLACP00000017765	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.961
ABL1	LOC102364341	ENSLACP00000017765	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.961
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	CRKL	ENSLACP00000006377	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.961
ABL2	LOC102364341	ENSLACP00000006377	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.961
APP	CD74	ENSLACP00000001643	ENSLACP00000018188	Amyloid beta precursor protein.	CD74 molecule.	0.700
APP	TGFB1	ENSLACP00000001643	ENSLACP00000020652	Amyloid beta precursor protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.550
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	BMPER	ENSLACP00000016168	ENSLACP00000022404	Bone morphogenetic protein 2.	BMP binding endothelial regulator.	0.484
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF18	ENSLACP00000016168	ENSLACP00000015472	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
BMP2	FGF19	ENSLACP00000016168	ENSLACP00000014596	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.430
BMP2	FGF4	ENSLACP00000016168	ENSLACP00000014225	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP2	H3A2B0_LATCH	ENSLACP00000016168	ENSLACP00000003781	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.402
BMP2	LOC102356182	ENSLACP00000016168	ENSLACP00000006376	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.508
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
BMP4	BMPER	ENSLACP00000021723	ENSLACP00000022404	Bone morphogenetic protein 4.	BMP binding endothelial regulator.	0.484
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499