(15 nodes) I-SMAD binding network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	INTS8	Integrator complex subunit 8. (894 aa)
	SMAD6	Mothers against decapentaplegic homolog. (485 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	SMAD5	Mothers against decapentaplegic homolog. (467 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	SMAD3	Mothers against decapentaplegic homolog. (358 aa)
	SMAD9	Mothers against decapentaplegic homolog. (467 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	AXIN1	Axin 1. (880 aa)
	H3AVW8_LATCH	Mothers against decapentaplegic homolog. (369 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	AXIN2	Axin 2. (841 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	AXIN2	ENSLACP00000013211	ENSLACP00000019725	Axin 1.	Axin 2.	0.903
AXIN1	CTNNB1	ENSLACP00000013211	ENSLACP00000017209	Axin 1.	Catenin beta 1.	0.996
AXIN2	AXIN1	ENSLACP00000019725	ENSLACP00000013211	Axin 2.	Axin 1.	0.903
AXIN2	CTNNB1	ENSLACP00000019725	ENSLACP00000017209	Axin 2.	Catenin beta 1.	0.995
CTNNB1	AXIN1	ENSLACP00000017209	ENSLACP00000013211	Catenin beta 1.	Axin 1.	0.996
CTNNB1	AXIN2	ENSLACP00000017209	ENSLACP00000019725	Catenin beta 1.	Axin 2.	0.995
CTNNB1	LOC102358988	ENSLACP00000017209	ENSLACP00000022115	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.627
CTNNB1	SMAD1	ENSLACP00000017209	ENSLACP00000012771	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.586
CTNNB1	SMAD2	ENSLACP00000017209	ENSLACP00000008339	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.737
CTNNB1	SMAD3	ENSLACP00000017209	ENSLACP00000011989	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.737
CTNNB1	SMAD4	ENSLACP00000017209	ENSLACP00000009312	Catenin beta 1.	MH2 domain-containing protein.	0.627
CTNNB1	SMAD5	ENSLACP00000017209	ENSLACP00000008275	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.513
CTNNB1	SMAD6	ENSLACP00000017209	ENSLACP00000006043	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.415
CTNNB1	SMAD7	ENSLACP00000017209	ENSLACP00000006551	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.704
CTNNB1	SMAD9	ENSLACP00000017209	ENSLACP00000012687	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.414
CTNNB1	TGFBR1	ENSLACP00000017209	ENSLACP00000008197	Catenin beta 1.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.575
H3AVW8_LATCH	LOC102358988	ENSLACP00000013789	ENSLACP00000022115	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.477
H3AVW8_LATCH	SMAD4	ENSLACP00000013789	ENSLACP00000009312	Mothers against decapentaplegic homolog.	MH2 domain-containing protein.	0.477
H3AVW8_LATCH	TGFBR1	ENSLACP00000013789	ENSLACP00000008197	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.613
INTS8	LOC102358988	ENSLACP00000002911	ENSLACP00000022115	Integrator complex subunit 8.	Mothers against decapentaplegic homolog.	0.770