(48 nodes) Regulation of protein processing network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102356340	Uncharacterized protein. (667 aa)
	LOC102351080	Metalloendopeptidase. (501 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	NLRC4	NLR family CARD domain containing 4. (1032 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	CLEC3B	C-type lectin domain family 3 member B. (200 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (223 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (1012 aa)
	LOC102353726	Metalloendopeptidase. (447 aa)
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	LOC102351334	Scinderin like a. (721 aa)
	CPB2	Carboxypeptidase B2. (426 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	IL1R2	Interleukin 1 receptor type 2. (378 aa)
	BAG2	BCL2 associated athanogene 2. (212 aa)
	LOC102356298	Uncharacterized protein. (236 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (403 aa)
	LOC102363099	S_100 domain-containing protein; Belongs to the S-100 family. (98 aa)
	CLN3	Battenin. (406 aa)
	LOC106706281	Metalloendopeptidase. (540 aa)
	SERPINF2	Serpin family F member 2; Belongs to the serpin family. (394 aa)
	NKD2	NKD inhibitor of WNT signaling pathway 2. (387 aa)
	CST7	Cystatin F. (139 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (430 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (357 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	GAS1	Growth arrest specific 1. (259 aa)
	SPON1	Spondin 1. (682 aa)
	RNF139	Ring finger protein 139. (661 aa)
	H2ZRW3_LATCH	Metalloendopeptidase. (131 aa)
	LOC102350617	Uncharacterized protein. (222 aa)
	LOC102347538	Metalloendopeptidase. (393 aa)
	IFT52	Intraflagellar transport 52. (440 aa)
	LOC102359537	Metalloendopeptidase. (448 aa)
	LOC102355791	Metalloendopeptidase. (352 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	RFX4	Regulatory factor X4. (739 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC102365238	Ribosomal protein S6 kinase. (740 aa)
	LOC102361687	Uncharacterized protein. (188 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (295 aa)
	LOC102345144	Rhomboid domain-containing protein. (186 aa)
	CNTN2	Contactin 2. (1026 aa)
	LDLRAD3	Low density lipoprotein receptor class A domain containing 3. (328 aa)
	H3B0V0_LATCH	Uncharacterized protein. (213 aa)
	HPN	Hepsin; Belongs to the peptidase S1 family. (415 aa)
	RHBDD1	Rhomboid domain containing 1. (318 aa)
	LOC102351337	Metalloendopeptidase. (496 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG2	LOC102361687	ENSLACP00000005803	ENSLACP00000017257	BCL2 associated athanogene 2.	Uncharacterized protein.	0.905
CCBE1	CHAC1	ENSLACP00000001053	ENSLACP00000013183	Collagen and calcium binding EGF domains 1.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.467
CHAC1	CCBE1	ENSLACP00000013183	ENSLACP00000001053	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	Collagen and calcium binding EGF domains 1.	0.467
CPB2	SERPINE1	ENSLACP00000006320	ENSLACP00000006192	Carboxypeptidase B2.	Serpin family E member 1; Belongs to the serpin family.	0.467
CPB2	SERPINF2	ENSLACP00000006320	ENSLACP00000003724	Carboxypeptidase B2.	Serpin family F member 2; Belongs to the serpin family.	0.653
LOC102361687	BAG2	ENSLACP00000017257	ENSLACP00000005803	Uncharacterized protein.	BCL2 associated athanogene 2.	0.905
LOC102362951	PRKACB	ENSLACP00000007730	ENSLACP00000014312	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
NKD2	RFX4	ENSLACP00000003189	ENSLACP00000019653	NKD inhibitor of WNT signaling pathway 2.	Regulatory factor X4.	0.572
PRKACB	LOC102362951	ENSLACP00000014312	ENSLACP00000007730	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.900
RFX4	NKD2	ENSLACP00000019653	ENSLACP00000003189	Regulatory factor X4.	NKD inhibitor of WNT signaling pathway 2.	0.572
SERPINE1	CPB2	ENSLACP00000006192	ENSLACP00000006320	Serpin family E member 1; Belongs to the serpin family.	Carboxypeptidase B2.	0.467
SERPINE1	SERPINE2	ENSLACP00000006192	ENSLACP00000005293	Serpin family E member 1; Belongs to the serpin family.	Serpin family E member 2; Belongs to the serpin family.	0.666
SERPINE1	THBS1	ENSLACP00000006192	ENSLACP00000020712	Serpin family E member 1; Belongs to the serpin family.	Thrombospondin 1.	0.542
SERPINE2	SERPINE1	ENSLACP00000005293	ENSLACP00000006192	Serpin family E member 2; Belongs to the serpin family.	Serpin family E member 1; Belongs to the serpin family.	0.666
SERPINF2	CPB2	ENSLACP00000003724	ENSLACP00000006320	Serpin family F member 2; Belongs to the serpin family.	Carboxypeptidase B2.	0.653
THBS1	SERPINE1	ENSLACP00000020712	ENSLACP00000006192	Thrombospondin 1.	Serpin family E member 1; Belongs to the serpin family.	0.542