(57 nodes) Positive regulation of leukocyte proliferation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	NFATC2	Nuclear factor of activated T cells 2. (912 aa)
	HHLA2	Ig-like domain-containing protein. (145 aa)
	M3XIR6_LATCH	Uncharacterized protein. (269 aa)
	M3XIM8_LATCH	Ig-like domain-containing protein. (241 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	IL18	Uncharacterized protein. (200 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	ZNF335	Zinc finger protein 335. (1379 aa)
	ATAD5	ATPase family AAA domain containing 5. (1828 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	H3BAX4_LATCH	DC_STAMP domain-containing protein. (450 aa)
	CD74	CD74 molecule. (279 aa)
	PELI1	Pellino E3 ubiquitin protein ligase 1. (445 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
	CD276	CD276 molecule. (324 aa)
	VTCN1-2	Uncharacterized protein. (232 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	LOC102363504	Tyrosine-protein kinase. (1116 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	DHPS	Deoxyhypusine synthase. (365 aa)
	LOC102358329	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (161 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	LOC102346566	Annexin. (343 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	FADD	Fas associated via death domain. (193 aa)
	IL6	Uncharacterized protein. (149 aa)
	H3AHE4_LATCH	Uncharacterized protein. (463 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (854 aa)
	SLC7A1	Solute carrier family 7 member 1. (658 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (836 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (247 aa)
	JAK2	Tyrosine-protein kinase. (1152 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (122 aa)
	H3A8Y5_LATCH	Uncharacterized protein. (477 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	H2ZZ29_LATCH	Uncharacterized protein. (442 aa)
	LOC102346338	ZP domain-containing protein. (328 aa)
	NMBR	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (279 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (235 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD11	FADD	ENSLACP00000004229	ENSLACP00000009943	Caspase recruitment domain family member 11.	Fas associated via death domain.	0.463
CARD11	LOC102348796	ENSLACP00000004229	ENSLACP00000023619	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.521
CARD11	RIPK2	ENSLACP00000004229	ENSLACP00000004499	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.521
CARD11	SYK	ENSLACP00000004229	ENSLACP00000012982	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.692
CARD11	TRAF6	ENSLACP00000004229	ENSLACP00000003556	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.833
CARD11	ZAP70	ENSLACP00000004229	ENSLACP00000008633	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.600
CD276	CD40	ENSLACP00000017684	ENSLACP00000004148	CD276 molecule.	TNFR-Cys domain-containing protein.	0.488
CD276	CD40LG	ENSLACP00000017684	ENSLACP00000017831	CD276 molecule.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.597
CD40	CD276	ENSLACP00000004148	ENSLACP00000017684	TNFR-Cys domain-containing protein.	CD276 molecule.	0.488
CD40	CD40LG	ENSLACP00000004148	ENSLACP00000017831	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.992
CD40	CSF1R	ENSLACP00000004148	ENSLACP00000016266	TNFR-Cys domain-containing protein.	Colony stimulating factor 1 receptor.	0.457
CD40	FADD	ENSLACP00000004148	ENSLACP00000009943	TNFR-Cys domain-containing protein.	Fas associated via death domain.	0.435
CD40	IL6	ENSLACP00000004148	ENSLACP00000009318	TNFR-Cys domain-containing protein.	Uncharacterized protein.	0.683
CD40	LOC102358329	ENSLACP00000004148	ENSLACP00000012214	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.556
CD40	MYD88	ENSLACP00000004148	ENSLACP00000019094	TNFR-Cys domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.601
CD40	PTPRC	ENSLACP00000004148	ENSLACP00000003518	TNFR-Cys domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.470
CD40	TLR9	ENSLACP00000004148	ENSLACP00000020965	TNFR-Cys domain-containing protein.	Toll-like receptor 9.	0.488
CD40	TNFSF13B	ENSLACP00000004148	ENSLACP00000006159	TNFR-Cys domain-containing protein.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.697
CD40	TRAF6	ENSLACP00000004148	ENSLACP00000003556	TNFR-Cys domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.965
CD40	ZAP70	ENSLACP00000004148	ENSLACP00000008633	TNFR-Cys domain-containing protein.	Tyrosine-protein kinase.	0.438