STRINGSTRING
PMVK PMVK GPLD1 GPLD1 LOC102356233 LOC102356233 TGFB1 TGFB1 LRP6 LRP6 GRAMD1B GRAMD1B LOC102364376 LOC102364376 PODNL1 PODNL1 MLC1 MLC1 CYP7A1 CYP7A1 TGFBR1 TGFBR1 H3AB79_LATCH H3AB79_LATCH LOC102354799 LOC102354799 PODN PODN GRAMD1C GRAMD1C TGFBR2 TGFBR2 PTCH1 PTCH1 GRAMD1A GRAMD1A SMO SMO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMVKPhosphomevalonate kinase. (188 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
GRAMD1BGRAM domain containing 1Bb. (692 aa)
LOC102364376Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
PODNL1Podocan like 1. (599 aa)
MLC1Modulator of VRAC current 1. (378 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1. (514 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
H3AB79_LATCHUncharacterized protein. (135 aa)
LOC102354799Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
PODNPodocan. (621 aa)
GRAMD1CGRAM domain containing 1C. (564 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
PTCH1Patched 1. (1287 aa)
GRAMD1AGRAM domain containing 1A. (864 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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