STRINGSTRING
CRADD CRADD TMEM109 TMEM109 ITGB6 ITGB6 TP53INP1 TP53INP1 LOC102355203 LOC102355203 EIF2AK4 EIF2AK4 LOC102355825 LOC102355825 MAPK13 MAPK13 H2ZTV4_LATCH H2ZTV4_LATCH LOC102347948 LOC102347948 H2ZUT7_LATCH H2ZUT7_LATCH MAP3K2 MAP3K2 TRPV4 TRPV4 GCLC GCLC H2ZWE3_LATCH H2ZWE3_LATCH IRF1 IRF1 H2ZWI5_LATCH H2ZWI5_LATCH GPLD1 GPLD1 CASP10 CASP10 H2ZYB6_LATCH H2ZYB6_LATCH RRH RRH SDE2 SDE2 PTGER4 PTGER4 CDCA7 CDCA7 RAB11FIP5 RAB11FIP5 CASP2 CASP2 LOC102365646 LOC102365646 PARP1 PARP1 LOC102354722 LOC102354722 NUCKS1 NUCKS1 LIG4 LIG4 SMPD1 SMPD1 H3A2R2_LATCH H3A2R2_LATCH MAP3K20 MAP3K20 LOC102349946 LOC102349946 CD40 CD40 TMEM150C TMEM150C CIITA CIITA CUL4A CUL4A H3A526_LATCH H3A526_LATCH TLR7 TLR7 PKD2 PKD2 H3A619_LATCH H3A619_LATCH WNK3 WNK3 CUL4B CUL4B H3A6P6_LATCH H3A6P6_LATCH ATM ATM POLK POLK MAG MAG NIPBL NIPBL LOC102354655 LOC102354655 H3A8P8_LATCH H3A8P8_LATCH FAS FAS PCNA PCNA BRCA1 BRCA1 PALM PALM CHP1 CHP1 ERRFI1 ERRFI1 CRB1 CRB1 BAX BAX ERCC4 ERCC4 PDE2A PDE2A SFRP2 SFRP2 BLM BLM ZMPSTE24 ZMPSTE24 ELK1 ELK1 RAD1 RAD1 H3ADL8_LATCH H3ADL8_LATCH H3AEK5_LATCH H3AEK5_LATCH PTPRK PTPRK MAP3K1 MAP3K1 KDM1A KDM1A H3AGP4_LATCH H3AGP4_LATCH LTBR LTBR LOC102351431 LOC102351431 SIRT1 SIRT1 TLK2 TLK2 H3AHH6_LATCH H3AHH6_LATCH OPN4 OPN4 LOC102352539 LOC102352539 PTGS2 PTGS2 NET1 NET1 INTS7 INTS7 SCNN1A SCNN1A INO80 INO80 TP53BP1 TP53BP1 FADD FADD EIF2S1 EIF2S1 POLD3 POLD3 OPN3 OPN3 STK39 STK39 H3AM01_LATCH H3AM01_LATCH LOC102356355 LOC102356355 RAD9A RAD9A MAP3K14 MAP3K14 ATR ATR BAD BAD XPC XPC USP47 USP47 PIEZO1 PIEZO1 XRCC6 XRCC6 SLC4A11 SLC4A11 LOC102357108 LOC102357108 BMP6 BMP6 LRRC8C LRRC8C LOC102359041 LOC102359041 TMEM161A TMEM161A BAG3 BAG3 TLR3 TLR3 POLH POLH STK11 STK11 H3AU40_LATCH H3AU40_LATCH SCNN1G SCNN1G ANKRD1 ANKRD1 LOC102351332 LOC102351332 SCNN1B SCNN1B LRRC8D LRRC8D KCNK18 KCNK18 ECT2 ECT2 LRRC8E LRRC8E H3AYA9_LATCH H3AYA9_LATCH MMP9 MMP9 RHO RHO BNIP3 BNIP3 RHBDD1 RHBDD1 RGR RGR NSMF NSMF OPN5 OPN5 XPA XPA TP53 TP53 METTL3 METTL3 PPID PPID LOC102345144 LOC102345144 PIEZO2 PIEZO2 CNN2 CNN2 ACTR5 ACTR5 SPIDR SPIDR POLD1 POLD1 PIK3CA PIK3CA BAK1 BAK1 DHX36 DHX36 ZBTB1 ZBTB1 LOC102347432 LOC102347432 TLR8 TLR8 CHEK1 CHEK1 XRCC5 XRCC5 MYD88 MYD88 TNFSF14 TNFSF14 PBK PBK RAD51 RAD51 KCNK4 KCNK4 MYC MYC PKD2L1 PKD2L1 NOC2L NOC2L DDB1 DDB1 CHEK2 CHEK2 LOC102362374 LOC102362374 RUVBL2 RUVBL2 LOC102363355 LOC102363355 TGFB1 TGFB1 CASP9 CASP9 SCNN1D SCNN1D CRYAB CRYAB CRB2 CRB2 LOC102365550 LOC102365550 RAD9B RAD9B RHNO1 RHNO1 FBXO4 FBXO4 IMPACT IMPACT BARD1 BARD1 C9orf116 C9orf116 EPO EPO CREBBP CREBBP TANK TANK LOC102349202 LOC102349202 MAP2K4 MAP2K4 M3XL44_LATCH M3XL44_LATCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (143 aa)
TMEM109Uncharacterized protein. (257 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (675 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
LOC102355203Na_H_Exchanger domain-containing protein. (161 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1410 aa)
LOC102355825Opsin 4xa; Belongs to the G-protein coupled receptor 1 family. (260 aa)
MAPK13Mitogen-activated protein kinase. (162 aa)
H2ZTV4_LATCHIon_trans domain-containing protein. (103 aa)
LOC102347948Uncharacterized protein. (290 aa)
H2ZUT7_LATCHTIR domain-containing protein. (1060 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (664 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (655 aa)
H2ZWE3_LATCHUncharacterized protein. (222 aa)
IRF1Interferon regulatory factor. (264 aa)
H2ZWI5_LATCHUncharacterized protein. (1469 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (539 aa)
H2ZYB6_LATCHUncharacterized protein. (324 aa)
RRHRetinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (383 aa)
SDE2SDE2 telomere maintenance homolog. (418 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (455 aa)
CDCA7Cell division cycle associated 7. (405 aa)
RAB11FIP5RAB11 family interacting protein 5. (389 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (433 aa)
LOC102365646Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (345 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
LOC102354722Uncharacterized protein. (116 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (295 aa)
LIG4DNA ligase. (911 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (396 aa)
H3A2R2_LATCHUncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
MAP3K20Uncharacterized protein. (792 aa)
LOC102349946G_PROTEIN_RECEP_F1_2 domain-containing protein. (361 aa)
CD40TNFR-Cys domain-containing protein. (167 aa)
TMEM150CTransmembrane protein 150C. (186 aa)
CIITAClass II major histocompatibility complex transactivator. (793 aa)
CUL4ACullin 4A; Belongs to the cullin family. (851 aa)
H3A526_LATCHUncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
TLR7Toll-like receptor 7. (1033 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (890 aa)
H3A619_LATCHANK_REP_REGION domain-containing protein. (363 aa)
WNK3WNK lysine deficient protein kinase 3. (1769 aa)
CUL4BCullin 4B; Belongs to the cullin family. (845 aa)
H3A6P6_LATCHANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (593 aa)
ATMATM serine/threonine kinase. (2375 aa)
POLKDNA polymerase kappa. (873 aa)
MAGMyelin associated glycoprotein. (633 aa)
NIPBLNipped-B protein. (2707 aa)
LOC102354655ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (600 aa)
H3A8P8_LATCHDUF4502 domain-containing protein. (165 aa)
FASUncharacterized protein. (330 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
PALMParalemmin. (392 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (468 aa)
CRB1Crumbs cell polarity complex component 1. (1366 aa)
BAXUncharacterized protein. (223 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (919 aa)
PDE2APhosphodiesterase. (705 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
BLMBLM RecQ like helicase. (1450 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
ELK1ETS transcription factor ELK1. (520 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
H3ADL8_LATCHANK_REP_REGION domain-containing protein. (405 aa)
H3AEK5_LATCHAquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (565 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1408 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (820 aa)
H3AGP4_LATCHTower domain-containing protein. (1245 aa)
LTBRLymphotoxin beta receptor. (377 aa)
LOC102351431Uncharacterized protein. (229 aa)
SIRT1Sirtuin 1. (729 aa)
TLK2Tousled like kinase 2. (747 aa)
H3AHH6_LATCHRHD domain-containing protein. (288 aa)
OPN4Opsin 4. (517 aa)
LOC102352539Uncharacterized protein. (949 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (620 aa)
NET1Neuroepithelial cell transforming 1. (631 aa)
INTS7Integrator complex subunit 7. (843 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (653 aa)
INO80INO80 complex ATPase subunit. (1542 aa)
TP53BP1Tumor protein p53 binding protein 1. (2149 aa)
FADDFas associated via death domain. (193 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
POLD3Uncharacterized protein. (373 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (155 aa)
STK39Serine/threonine kinase 39. (493 aa)
H3AM01_LATCHIntegrin beta; Belongs to the integrin beta chain family. (769 aa)
LOC102356355TNFR-Cys domain-containing protein. (163 aa)
RAD9AUncharacterized protein. (273 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (940 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa)
BADUncharacterized protein. (175 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (915 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1381 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2125 aa)
XRCC6X-ray repair cross complementing 6. (610 aa)
SLC4A11Solute carrier family 4 member 11. (853 aa)
LOC102357108Opsin 1 (cone pigments), short-wave-sensitive 2. (360 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (805 aa)
LOC102359041Zgc:153993. (208 aa)
TMEM161ATransmembrane protein 161A. (482 aa)
BAG3BCL2 associated athanogene 3. (561 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
POLHDNA polymerase eta. (729 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
H3AU40_LATCHPiezo-type mechanosensitive ion channel component. (2543 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
LOC102351332Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
LRRC8DLeucine rich repeat containing 8 VRAC subunit D. (848 aa)
KCNK18Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (400 aa)
ECT2Epithelial cell transforming 2. (919 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (793 aa)
H3AYA9_LATCHProtein kinase domain-containing protein. (357 aa)
MMP9Matrix metallopeptidase 9. (682 aa)
RHORhodopsin. (355 aa)
BNIP3BCL2 interacting protein 3. (202 aa)
RHBDD1Rhomboid domain containing 1. (318 aa)
RGRRetinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (524 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (290 aa)
XPAXPA, DNA damage recognition and repair factor. (274 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
PPIDPeptidylprolyl isomerase D. (309 aa)
LOC102345144Rhomboid domain-containing protein. (186 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2426 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (302 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (594 aa)
SPIDRDUF4503 domain-containing protein. (397 aa)
POLD1DNA polymerase. (1103 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
BAK1BCL2 antagonist/killer 1. (239 aa)
DHX36DEAH-box helicase 36. (1001 aa)
ZBTB1Zinc finger and BTB domain containing 1. (706 aa)
LOC102347432Rhodopsin. (355 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
XRCC5X-ray repair cross complementing 5. (606 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
TNFSF14TNF_2 domain-containing protein. (238 aa)
PBKPDZ binding kinase. (336 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (444 aa)
MYCTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (412 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (741 aa)
NOC2LUncharacterized protein. (702 aa)
DDB1Damage specific DNA binding protein 1. (1142 aa)
CHEK2Checkpoint kinase 2. (411 aa)
LOC102362374G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (316 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (466 aa)
LOC102363355ETS domain-containing protein. (380 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (457 aa)
SCNN1DSodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (565 aa)
CRYABCrystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (173 aa)
CRB2Uncharacterized protein. (1473 aa)
LOC102365550Uncharacterized protein. (218 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (319 aa)
FBXO4F-box protein 4. (348 aa)
IMPACTImpact RWD domain protein. (319 aa)
BARD1BRCA1 associated RING domain 1. (866 aa)
C9orf116Chromosome 9 open reading frame 116. (135 aa)
EPOErythropoietin. (179 aa)
CREBBPCREB binding protein. (2411 aa)
TANKUncharacterized protein. (72 aa)
LOC102349202Vertebrate ancient long opsin b. (322 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (463 aa)
M3XL44_LATCHIon_trans domain-containing protein. (134 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (14%) [HD]