(52 nodes) Cellular response to acid chemical network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102356692	Si:zfos-80g12.1. (503 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	H3BA50_LATCH	Cytoplasmic polyadenylation element binding protein 1b. (486 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	AMIGO1	Adhesion molecule with Ig like domain 1. (506 aa)
	SESN2	Sestrin 2. (463 aa)
	SESN1	Sestrin 1. (463 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (92 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (369 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1334 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	RRAGC	Ras related GTP binding C. (383 aa)
	SH3BP4	SH3 domain binding protein 4. (960 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	SLC38A9	Solute carrier family 38 member 9. (561 aa)
	AMIGO3	Adhesion molecule with Ig like domain 3. (510 aa)
	HNRNPD	Heterogeneous nuclear ribonucleoprotein D. (309 aa)
	LAMTOR3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	LAMTOR4	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (103 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (798 aa)
	H3A2C7_LATCH	Uncharacterized protein. (683 aa)
	NTRK2	Tyrosine-protein kinase receptor. (819 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (655 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1724 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	SLC7A5	Solute carrier family 7 member 5. (522 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	BAIAP2	BAI1 associated protein 2. (434 aa)
	H3AZY7_LATCH	Kelch-like family member 22. (628 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (524 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1076 aa)
	H3AXK0_LATCH	Uncharacterized protein. (161 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (726 aa)
	RRAGB	Ras-related GTP binding A. (313 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (568 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	IPO5	Importin 5. (1107 aa)
	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B. (331 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1767 aa)
	SESN3	Sestrin 3. (323 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (684 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
	LAMTOR2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (136 aa)
	RRAGD	Ras related GTP binding D. (398 aa)
	LARS1	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1178 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL11A	DNMT1	ENSLACP00000003997	ENSLACP00000012502	BAF chromatin remodeling complex subunit BCL11A.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.452
CASTOR1	SLC38A9	ENSLACP00000012290	ENSLACP00000006212	Cytosolic arginine sensor for mTORC1 subunit 1.	Solute carrier family 38 member 9.	0.556
CPEB3	CPEB4	ENSLACP00000012841	ENSLACP00000018247	Cytoplasmic polyadenylation element binding protein 3.	Cytoplasmic polyadenylation element binding protein 4.	0.900
CPEB4	CPEB3	ENSLACP00000018247	ENSLACP00000012841	Cytoplasmic polyadenylation element binding protein 4.	Cytoplasmic polyadenylation element binding protein 3.	0.900
DNMT1	BCL11A	ENSLACP00000012502	ENSLACP00000003997	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	BAF chromatin remodeling complex subunit BCL11A.	0.452
DNMT1	H3A2C7_LATCH	ENSLACP00000012502	ENSLACP00000003798	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.452
DNMT1	HNRNPAB	ENSLACP00000012502	ENSLACP00000017289	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Heterogeneous nuclear ribonucleoprotein A/B.	0.425
DNMT1	HNRNPD	ENSLACP00000012502	ENSLACP00000005977	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Heterogeneous nuclear ribonucleoprotein D.	0.425
DNMT1	ZEB1	ENSLACP00000012502	ENSLACP00000015060	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Zinc finger E-box binding homeobox 1.	0.555
GCLC	GCLM	ENSLACP00000001656	ENSLACP00000012373	Glutamate-cysteine ligase catalytic subunit.	Glutamate-cysteine ligase modifier subunit.	0.998
GCLM	GCLC	ENSLACP00000012373	ENSLACP00000001656	Glutamate-cysteine ligase modifier subunit.	Glutamate-cysteine ligase catalytic subunit.	0.998
H3A2C7_LATCH	DNMT1	ENSLACP00000003798	ENSLACP00000012502	Uncharacterized protein.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.452
H3AXK0_LATCH	H3B8U3_LATCH	ENSLACP00000014371	ENSLACP00000018314	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.855
H3AXK0_LATCH	LAMTOR2	ENSLACP00000014371	ENSLACP00000012406	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.999
H3AXK0_LATCH	LAMTOR3	ENSLACP00000014371	ENSLACP00000005133	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3.	0.999
H3AXK0_LATCH	LAMTOR4	ENSLACP00000014371	ENSLACP00000004196	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4.	0.999
H3AXK0_LATCH	LAMTOR5	ENSLACP00000014371	ENSLACP00000020960	Uncharacterized protein.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.999
H3AXK0_LATCH	LOC102351332	ENSLACP00000014371	ENSLACP00000013502	Uncharacterized protein.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.403
H3AXK0_LATCH	LOC102356692	ENSLACP00000014371	ENSLACP00000010472	Uncharacterized protein.	Si:zfos-80g12.1.	0.454
H3AXK0_LATCH	MTOR	ENSLACP00000014371	ENSLACP00000018843	Uncharacterized protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.855