(61 nodes) Cellular response to calcium ion network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYT2	Synaptotagmin 2. (421 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (553 aa)
	RASAL1	RAS protein activator like 1. (620 aa)
	SYT8	Synaptotagmin 8. (400 aa)
	SYT5	Uncharacterized protein. (371 aa)
	LOC102345511	Uncharacterized protein. (292 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
	CPNE8	Copine 8. (383 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	SYT11	Synaptotagmin 11. (429 aa)
	CPNE4	Copine 4. (190 aa)
	ITPKA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (308 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	SMPD1	Sphingomyelin phosphodiesterase 1. (396 aa)
	SYT10	Synaptotagmin 10. (358 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (512 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (311 aa)
	SYT15	Uncharacterized protein. (424 aa)
	MEF2A	Myocyte enhancer factor 2A. (468 aa)
	LOC102351204	DUF1053 domain-containing protein. (254 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	GUCA1A	Guanylate cyclase activator 1A. (202 aa)
	CPNE3	Copine 3. (535 aa)
	SYT3	Synaptotagmin 3. (538 aa)
	SYT17	Synaptotagmin 17. (473 aa)
	ADGRV1	Adhesion G protein-coupled receptor V1. (5847 aa)
	H3ALW6_LATCH	Uncharacterized protein. (286 aa)
	NCSTN	Nicastrin. (680 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (302 aa)
	CPNE9	Copine family member 9. (441 aa)
	SYT1	Synaptotagmin 1. (384 aa)
	ADCY8	AC_N domain-containing protein. (266 aa)
	H3AQU6_LATCH	AC_N domain-containing protein. (191 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	ACER1	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (272 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	MEF2C	Myocyte enhancer factor 2C. (462 aa)
	SYT9	Synaptotagmin 9. (454 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	ADD1	Adducin 1. (805 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (350 aa)
	SYT4	Synaptotagmin 4. (434 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1473 aa)
	LOC102349192	Copine VII. (415 aa)
	CLIC4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
	CPNE2	Copine 2. (550 aa)
	CARF	Calcium responsive transcription factor. (734 aa)
	JUND	BZIP domain-containing protein. (293 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	CPNE5	VWFA domain-containing protein. (324 aa)
	H3BEX1_LATCH	C2 domain-containing protein. (85 aa)
	LOC102359280	Kinase; Belongs to the inositol phosphokinase (IPK) family. (296 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (391 aa)
	SYT6	Synaptotagmin 6. (470 aa)
	SYT13	Synaptotagmin 13. (444 aa)
	LOC102345704	RAS p21 protein activator 4. (808 aa)
	ITPKC	Kinase; Belongs to the inositol phosphokinase (IPK) family. (300 aa)
	LGMN	Legumain. (436 aa)
	CHP2	Calcineurin like EF-hand protein 2. (194 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	DMTN	ENSLACP00000014663	ENSLACP00000019018	Adducin 1.	Dematin actin binding protein.	0.877
CPNE4	CPNE5	ENSLACP00000004345	ENSLACP00000020305	Copine 4.	VWFA domain-containing protein.	0.949
CPNE5	CPNE4	ENSLACP00000020305	ENSLACP00000004345	VWFA domain-containing protein.	Copine 4.	0.949
CPNE5	H3BEX1_LATCH	ENSLACP00000020305	ENSLACP00000020442	VWFA domain-containing protein.	C2 domain-containing protein.	0.869
CPNE8	H3BEX1_LATCH	ENSLACP00000004965	ENSLACP00000020442	Copine 8.	C2 domain-containing protein.	0.876
CPNE9	H3BEX1_LATCH	ENSLACP00000011254	ENSLACP00000020442	Copine family member 9.	C2 domain-containing protein.	0.870
DMTN	ADD1	ENSLACP00000019018	ENSLACP00000014663	Dematin actin binding protein.	Adducin 1.	0.877
FOS	FOSB	ENSLACP00000020665	ENSLACP00000014848	Fos proto-oncogene, AP-1 transcription factor subunit.	FosB proto-oncogene, AP-1 transcription factor subunit.	0.937
FOS	H3AD77_LATCH	ENSLACP00000020665	ENSLACP00000007598	Fos proto-oncogene, AP-1 transcription factor subunit.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.998
FOS	JUN	ENSLACP00000020665	ENSLACP00000005596	Fos proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.999
FOS	JUNB	ENSLACP00000020665	ENSLACP00000001704	Fos proto-oncogene, AP-1 transcription factor subunit.	JunB proto-oncogene, AP-1 transcription factor subunit.	0.987
FOS	JUND	ENSLACP00000020665	ENSLACP00000017669	Fos proto-oncogene, AP-1 transcription factor subunit.	BZIP domain-containing protein.	0.952
FOSB	FOS	ENSLACP00000014848	ENSLACP00000020665	FosB proto-oncogene, AP-1 transcription factor subunit.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.937
FOSB	H3AD77_LATCH	ENSLACP00000014848	ENSLACP00000007598	FosB proto-oncogene, AP-1 transcription factor subunit.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.950
FOSB	JUN	ENSLACP00000014848	ENSLACP00000005596	FosB proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.950
FOSB	JUNB	ENSLACP00000014848	ENSLACP00000001704	FosB proto-oncogene, AP-1 transcription factor subunit.	JunB proto-oncogene, AP-1 transcription factor subunit.	0.916
FOSB	JUND	ENSLACP00000014848	ENSLACP00000017669	FosB proto-oncogene, AP-1 transcription factor subunit.	BZIP domain-containing protein.	0.985
H3AD77_LATCH	FOS	ENSLACP00000007598	ENSLACP00000020665	JunE proto-oncogene, AP-1 transcription factor subunit.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.998
H3AD77_LATCH	FOSB	ENSLACP00000007598	ENSLACP00000014848	JunE proto-oncogene, AP-1 transcription factor subunit.	FosB proto-oncogene, AP-1 transcription factor subunit.	0.950
H3AD77_LATCH	JUN	ENSLACP00000007598	ENSLACP00000005596	JunE proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.901