STRINGSTRING
KDM1A KDM1A CHEK2 CHEK2 TMEM109 TMEM109 ITGB6 ITGB6 H2ZWI5_LATCH H2ZWI5_LATCH CDCA7 CDCA7 NUCKS1 NUCKS1 LIG4 LIG4 MAP3K20 MAP3K20 ATM ATM NIPBL NIPBL H3A8P8_LATCH H3A8P8_LATCH BRCA1 BRCA1 XRCC5 XRCC5 SFRP2 SFRP2 BLM BLM ZMPSTE24 ZMPSTE24 ELK1 ELK1 RAD1 RAD1 H3AGP4_LATCH H3AGP4_LATCH SIRT1 SIRT1 TLK2 TLK2 NET1 NET1 INTS7 INTS7 INO80 INO80 TP53BP1 TP53BP1 RAD9A RAD9A ATR ATR XRCC6 XRCC6 ECT2 ECT2 TP53 TP53 SPIDR SPIDR RAD51 RAD51 LOC102363355 LOC102363355 TGFB1 TGFB1 CRYAB CRYAB RAD9B RAD9B RHNO1 RHNO1 FBXO4 FBXO4 BARD1 BARD1 TANK TANK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (820 aa)
CHEK2Checkpoint kinase 2. (411 aa)
TMEM109Uncharacterized protein. (257 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (675 aa)
H2ZWI5_LATCHUncharacterized protein. (1469 aa)
CDCA7Cell division cycle associated 7. (405 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (295 aa)
LIG4DNA ligase. (911 aa)
MAP3K20Uncharacterized protein. (792 aa)
ATMATM serine/threonine kinase. (2375 aa)
NIPBLNipped-B protein. (2707 aa)
H3A8P8_LATCHDUF4502 domain-containing protein. (165 aa)
BRCA1BRCA1 DNA repair associated. (1873 aa)
XRCC5X-ray repair cross complementing 5. (606 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
BLMBLM RecQ like helicase. (1450 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
ELK1ETS transcription factor ELK1. (520 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
H3AGP4_LATCHTower domain-containing protein. (1245 aa)
SIRT1Sirtuin 1. (729 aa)
TLK2Tousled like kinase 2. (747 aa)
NET1Neuroepithelial cell transforming 1. (631 aa)
INTS7Integrator complex subunit 7. (843 aa)
INO80INO80 complex ATPase subunit. (1542 aa)
TP53BP1Tumor protein p53 binding protein 1. (2149 aa)
RAD9AUncharacterized protein. (273 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa)
XRCC6X-ray repair cross complementing 6. (610 aa)
ECT2Epithelial cell transforming 2. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
SPIDRDUF4503 domain-containing protein. (397 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
LOC102363355ETS domain-containing protein. (380 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
CRYABCrystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (173 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (319 aa)
FBXO4F-box protein 4. (348 aa)
BARD1BRCA1 associated RING domain 1. (866 aa)
TANKUncharacterized protein. (72 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.