(17 nodes) Tail-anchored membrane protein insertion into ER membrane network (Latimeria chalumnae)

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Your Input:
	EMC2	ER membrane protein complex subunit 2. (297 aa)
	EMC8	ER membrane protein complex subunit 8. (204 aa)
	EMC6	ER membrane protein complex subunit 6. (112 aa)
	SGTA	Small glutamine rich tetratricopeptide repeat containing alpha. (316 aa)
	EMC9	ER membrane protein complex subunit 9. (208 aa)
	GET4	Guided entry of tail-anchored proteins factor 4. (326 aa)
	H3ANR7_LATCH	Tugs domain-containing protein. (77 aa)
	GET3	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (341 aa)
	EMC1	ER membrane protein complex subunit 1. (955 aa)
	EMC3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	MMGT1	Membrane magnesium transporter 1. (131 aa)
	GET1	Guided entry of tail-anchored proteins factor 1. (182 aa)
	EMC10	ER membrane protein complex subunit 10. (253 aa)
	CAMLG	Calcium modulating ligand. (307 aa)
	EMC4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (175 aa)
	LOC102352461	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (260 aa)
	BAG6	BCL2 associated athanogene 6. (995 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG6	GET3	ENSLACP00000003772	ENSLACP00000010276	BCL2 associated athanogene 6.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.784
BAG6	GET4	ENSLACP00000003772	ENSLACP00000017371	BCL2 associated athanogene 6.	Guided entry of tail-anchored proteins factor 4.	0.986
BAG6	H3ANR7_LATCH	ENSLACP00000003772	ENSLACP00000011288	BCL2 associated athanogene 6.	Tugs domain-containing protein.	0.966
BAG6	SGTA	ENSLACP00000003772	ENSLACP00000003207	BCL2 associated athanogene 6.	Small glutamine rich tetratricopeptide repeat containing alpha.	0.916
CAMLG	EMC6	ENSLACP00000010072	ENSLACP00000003225	Calcium modulating ligand.	ER membrane protein complex subunit 6.	0.420
CAMLG	GET1	ENSLACP00000010072	ENSLACP00000023185	Calcium modulating ligand.	Guided entry of tail-anchored proteins factor 1.	0.981
CAMLG	GET3	ENSLACP00000010072	ENSLACP00000010276	Calcium modulating ligand.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.958
CAMLG	GET4	ENSLACP00000010072	ENSLACP00000017371	Calcium modulating ligand.	Guided entry of tail-anchored proteins factor 4.	0.575
CAMLG	H3ANR7_LATCH	ENSLACP00000010072	ENSLACP00000011288	Calcium modulating ligand.	Tugs domain-containing protein.	0.488
CAMLG	SGTA	ENSLACP00000010072	ENSLACP00000003207	Calcium modulating ligand.	Small glutamine rich tetratricopeptide repeat containing alpha.	0.596
EMC1	EMC10	ENSLACP00000021798	ENSLACP00000018058	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 10.	0.971
EMC1	EMC2	ENSLACP00000021798	ENSLACP00000005513	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 2.	0.999
EMC1	EMC3	ENSLACP00000021798	ENSLACP00000020953	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.958
EMC1	EMC4	ENSLACP00000021798	ENSLACP00000006641	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	0.999
EMC1	EMC6	ENSLACP00000021798	ENSLACP00000003225	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 6.	0.982
EMC1	EMC8	ENSLACP00000021798	ENSLACP00000003498	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 8.	0.969
EMC1	EMC9	ENSLACP00000021798	ENSLACP00000002397	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 9.	0.956
EMC1	LOC102352461	ENSLACP00000021798	ENSLACP00000005796	ER membrane protein complex subunit 1.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.930
EMC1	MMGT1	ENSLACP00000021798	ENSLACP00000019209	ER membrane protein complex subunit 1.	Membrane magnesium transporter 1.	0.980
EMC10	EMC1	ENSLACP00000018058	ENSLACP00000021798	ER membrane protein complex subunit 10.	ER membrane protein complex subunit 1.	0.971