STRINGSTRING
MAP2K7 MAP2K7 LOC102356182 LOC102356182 RICTOR RICTOR TELO2 TELO2 CAB39 CAB39 RPS3 RPS3 LTA LTA PIK3CG PIK3CG H3AEV1_LATCH H3AEV1_LATCH STRADB STRADB CKS2 CKS2 DUSP19 DUSP19 SIRT1 SIRT1 NEK10 NEK10 TNFSF11 TNFSF11 CAB39L CAB39L LOC102356575 LOC102356575 LOC102345793 LOC102345793 RAPGEF2 RAPGEF2 ADAM17 ADAM17 MAP3K11 MAP3K11 H3AMR9_LATCH H3AMR9_LATCH MAP3K7 MAP3K7 RASGRP1 RASGRP1 NOX4 NOX4 CDK5R1 CDK5R1 AJUBA AJUBA ALS2 ALS2 PSEN1 PSEN1 LOC102362971 LOC102362971 CKS1B CKS1B H3ATF5_LATCH H3ATF5_LATCH SYK SYK ERN2 ERN2 ATP2B4 ATP2B4 LRRK2 LRRK2 RGCC RGCC SPDYA SPDYA PDCD10 PDCD10 LOC102355766 LOC102355766 MAP2K5 MAP2K5 LOC102359313 LOC102359313 PIH1D1 PIH1D1 PSMD10 PSMD10 H3AYC1_LATCH H3AYC1_LATCH CCNK CCNK H3AYQ4_LATCH H3AYQ4_LATCH IRAK1 IRAK1 CCND1 CCND1 C1QTNF9 C1QTNF9 TENM4 TENM4 STRADA STRADA DBF4 DBF4 FGF1 FGF1 SPATC1 SPATC1 LOC102345953 LOC102345953 H3B0I5_LATCH H3B0I5_LATCH FGF18 FGF18 H3B277_LATCH H3B277_LATCH CSF1R CSF1R DRD4 DRD4 AKAP13 AKAP13 BMPR2 BMPR2 CD40LG CD40LG FAM20A FAM20A ERN1 ERN1 CCNYL1 CCNYL1 PARP16 PARP16 LOC102363206 LOC102363206 CDK5R2 CDK5R2 CIB1 CIB1 EDN1 EDN1 MLST8 MLST8 LOC102346019 LOC102346019 FGF2 FGF2 FLT1 FLT1 INCENP INCENP CCNT1 CCNT1 CCND2 CCND2 TGFA TGFA H3BEX6_LATCH H3BEX6_LATCH TGFB1 TGFB1 THBS1 THBS1 RASGRP4 RASGRP4 MNAT1 MNAT1 SPDYC SPDYC DELE1 DELE1 PSRC1 PSRC1 SPATC1L SPATC1L TPD52L1 TPD52L1 RPTOR RPTOR PDGFC PDGFC LOC102358266 LOC102358266 IGF2 IGF2 PKD2 PKD2 EPGN EPGN PTPN1 PTPN1 DIPK2A DIPK2A KIT KIT PIK3R5 PIK3R5 PKD1 PKD1 CD40 CD40 CCNY CCNY MAP3K12 MAP3K12 LOC102352528 LOC102352528 TRAF6 TRAF6 PTPRC PTPRC H3A007_LATCH H3A007_LATCH PDGFB PDGFB MAP3K4 MAP3K4 LOC102367471 LOC102367471 BMPR1A BMPR1A FZD4 FZD4 H2ZWV5_LATCH H2ZWV5_LATCH H2ZW26_LATCH H2ZW26_LATCH BMPR1B BMPR1B ROR2 ROR2 LOC102358853 LOC102358853 HTR2B HTR2B FZD8 FZD8 TAB1 TAB1 ADIPOQ ADIPOQ H2ZS97_LATCH H2ZS97_LATCH CCNT2 CCNT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K7Mitogen-activated protein kinase kinase 7. (439 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1664 aa)
TELO2Telomere maintenance 2. (833 aa)
CAB39Calcium binding protein 39. (341 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
LTALymphotoxin alpha. (166 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
STRADBSTE20 related adaptor beta. (421 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (213 aa)
SIRT1Sirtuin 1. (729 aa)
NEK10NIMA related kinase 10. (1033 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
LOC102356575Si:dkey-76k16.5. (260 aa)
LOC102345793Si:dkeyp-92c9.2. (294 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1514 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (831 aa)
H3AMR9_LATCHUncharacterized protein. (285 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (580 aa)
RASGRP1RAS guanyl releasing protein 1. (719 aa)
NOX4NADPH oxidase 4. (541 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (306 aa)
AJUBAUncharacterized protein. (526 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1678 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
LOC102362971Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (81 aa)
H3ATF5_LATCHCdc6_C domain-containing protein. (525 aa)
SYKTyrosine-protein kinase. (616 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (974 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1233 aa)
LRRK2Leucine rich repeat kinase 2. (2508 aa)
RGCCRegulator of cell cycle. (127 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (294 aa)
PDCD10Programmed cell death 10. (210 aa)
LOC102355766Uncharacterized protein. (524 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
LOC102359313Uncharacterized protein. (334 aa)
PIH1D1Uncharacterized protein. (294 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (234 aa)
H3AYC1_LATCHUncharacterized protein. (301 aa)
CCNKCyclin K; Belongs to the cyclin family. (605 aa)
H3AYQ4_LATCHUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (673 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
C1QTNF9C1q domain-containing protein. (198 aa)
TENM4Teneurin transmembrane protein 4. (1073 aa)
STRADASTE20 related adaptor alpha. (432 aa)
DBF4DBF4 zinc finger. (672 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
SPATC1Uncharacterized protein. (225 aa)
LOC102345953Cyclin D3; Belongs to the cyclin family. (292 aa)
H3B0I5_LATCHDBF4-type domain-containing protein. (315 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
H3B277_LATCHUncharacterized protein. (4290 aa)
CSF1RColony stimulating factor 1 receptor. (968 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (382 aa)
AKAP13PH domain-containing protein. (644 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
CD40LGCD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (544 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (956 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (343 aa)
PARP16Poly [ADP-ribose] polymerase. (330 aa)
LOC102363206Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (325 aa)
CIB1Calcium and integrin binding 1. (190 aa)
EDN1Endothelin 1. (216 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
LOC102346019C1q domain-containing protein. (226 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
INCENPINCENP_ARK-bind domain-containing protein. (887 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (731 aa)
CCND2Cyclin D2, b; Belongs to the cyclin family. (291 aa)
TGFATransforming growth factor alpha. (140 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
THBS1Thrombospondin 1. (1170 aa)
RASGRP4RAS guanyl releasing protein 4. (692 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
SPDYCSpeedy/RINGO cell cycle regulator family member C. (312 aa)
DELE1Uncharacterized protein. (461 aa)
PSRC1GTSE1_N domain-containing protein. (399 aa)
SPATC1LSperiolin_C domain-containing protein. (362 aa)
TPD52L1TPD52 like 1. (190 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1334 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
LOC102358266Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
IGF2Insulin like growth factor 2. (207 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (890 aa)
EPGNEpithelial mitogen. (161 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (439 aa)
DIPK2ADivergent protein kinase domain 2A. (434 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (814 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4241 aa)
CD40TNFR-Cys domain-containing protein. (167 aa)
CCNYCyclin Y; Belongs to the cyclin family. (257 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase. (904 aa)
LOC102352528G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (830 aa)
H3A007_LATCHUncharacterized protein. (52 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1425 aa)
LOC102367471Uncharacterized protein; Belongs to the cyclin family. (292 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
H2ZWV5_LATCHSolute carrier family 27 member 1a. (655 aa)
H2ZW26_LATCHUncharacterized protein. (352 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
LOC102358853Uncharacterized protein. (577 aa)
HTR2B5-hydroxytryptamine receptor 2B. (474 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (436 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (259 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (750 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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