STRINGSTRING
LOC102362405 LOC102362405 TRAF3IP1 TRAF3IP1 EDNRB EDNRB FGF1 FGF1 JMJD6 JMJD6 PTK7 PTK7 H3B0X9_LATCH H3B0X9_LATCH FOXC2 FOXC2 NUP133 NUP133 SIX2 SIX2 MYOCD MYOCD H3B277_LATCH H3B277_LATCH PTCD2 PTCD2 BMP2 BMP2 GREB1 GREB1 PKHD1 PKHD1 H3B4C9_LATCH H3B4C9_LATCH LAMB2 LAMB2 WNT4 WNT4 PYGO1 PYGO1 CTNNB1 CTNNB1 H3B5Z8_LATCH H3B5Z8_LATCH LOC102354417 LOC102354417 SPRY1 SPRY1 BASP1 BASP1 AMER1 AMER1 TFAP2E TFAP2E SULF1 SULF1 HELLS HELLS WT1 WT1 KIF26B KIF26B SOX8 SOX8 HOXC11 HOXC11 FGF2 FGF2 NF1 NF1 TNS2 TNS2 WNT6 WNT6 H3BCG1_LATCH H3BCG1_LATCH AP2B1 AP2B1 PLCE1 PLCE1 HNF1A HNF1A IFT20 IFT20 GCNT3 GCNT3 TGFB1 TGFB1 LOC102354637 LOC102354637 CASP9 CASP9 SIX4 SIX4 SIX1 SIX1 ZBTB16 ZBTB16 LRP4 LRP4 WNT1 WNT1 LOC102350297 LOC102350297 NUP160 NUP160 TP73 TP73 BMP4 BMP4 H3BIS0_LATCH H3BIS0_LATCH LRP2 LRP2 LOC102358988 LOC102358988 M3XHJ5_LATCH M3XHJ5_LATCH BMPER BMPER CENPF CENPF TTC8 TTC8 WDPCP WDPCP RPGRIP1L RPGRIP1L STRA6 STRA6 AGT AGT CTNNBIP1 CTNNBIP1 GDNF GDNF BAX BAX GREM1 GREM1 AGTR1 AGTR1 ILK ILK WNT11 WNT11 FOXC1 FOXC1 DACT2 DACT2 OSR1 OSR1 SMAD7 SMAD7 CTSH CTSH WNT9B WNT9B OSR2 OSR2 ANKS6 ANKS6 EDNRA EDNRA LOC102364659 LOC102364659 SMAD6 SMAD6 TCF21 TCF21 TST TST DLG5 DLG5 NLE1 NLE1 PKD2 PKD2 RET RET NUP85 NUP85 GLIS2 GLIS2 ITGA3 ITGA3 H3A4J9_LATCH H3A4J9_LATCH RDH10 RDH10 LOC102358239 LOC102358239 PKD1 PKD1 PAX8 PAX8 GLI3 GLI3 PTCH1 PTCH1 MTSS1 MTSS1 BAG6 BAG6 TFAP2A TFAP2A NOTCH3 NOTCH3 CEP290 CEP290 GATA3 GATA3 CER1 CER1 AP1B1 AP1B1 H3A0S5_LATCH H3A0S5_LATCH ENPEP ENPEP PDGFB PDGFB DCHS2 DCHS2 SMO SMO FREM2-2 FREM2-2 H2ZYH3_LATCH H2ZYH3_LATCH H2ZX66_LATCH H2ZX66_LATCH FREM3 FREM3 ARL3 ARL3 IFT88 IFT88 JAG1 JAG1 PTPRO PTPRO H2ZUH0_LATCH H2ZUH0_LATCH LOC102356625 LOC102356625 LGR5 LGR5 LOC102353790 LOC102353790 LOC102356000 LOC102356000 HS2ST1 HS2ST1 H3AC70_LATCH H3AC70_LATCH AQP11 AQP11 IFT27 IFT27 ZMPSTE24 ZMPSTE24 TMEM59L TMEM59L NPHS2 NPHS2 KCNJ8 KCNJ8 GCNT1 GCNT1 FGF8 FGF8 H3AEK5_LATCH H3AEK5_LATCH LOC102358221 LOC102358221 TGFBR1 TGFBR1 FREM2 FREM2 SMAD5 SMAD5 SMAD2 SMAD2 CRLF1 CRLF1 H3AFZ6_LATCH H3AFZ6_LATCH DLL3 DLL3 PRKX PRKX LOC102351081 LOC102351081 C1GALT1 C1GALT1 SMAD4 SMAD4 DLL1 DLL1 FOXS1 FOXS1 SULF2 SULF2 KANK2 KANK2 HSPB11 HSPB11 NPHP3 NPHP3 FLCN FLCN TFAP2B TFAP2B HOXD11 HOXD11 ID3 ID3 H3AMW9_LATCH H3AMW9_LATCH PCSK9 PCSK9 PYGO2 PYGO2 TBC1D32 TBC1D32 BICC1 BICC1 LOC102346475 LOC102346475 NUP107 NUP107 SMAD3 SMAD3 H3AR28_LATCH H3AR28_LATCH EFNB2 EFNB2 H3ARL7_LATCH H3ARL7_LATCH SLIT2 SLIT2 BMP6 BMP6 GREB1L GREB1L ZBTB14 ZBTB14 SMAD1 SMAD1 GCNT4 GCNT4 TSC1 TSC1 CNTRL CNTRL WFS1 WFS1 IRX3 IRX3 TRAF3IP2 TRAF3IP2 LRRK2 LRRK2 LGR4 LGR4 PLXND1 PLXND1 H3AVW8_LATCH H3AVW8_LATCH SGPL1 SGPL1 MAGI2 MAGI2 LOC102358151 LOC102358151 COMMD5 COMMD5 TSHZ1 TSHZ1 IRX1 IRX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102362405Homeobox domain-containing protein. (954 aa)
TRAF3IP1TRAF3 interacting protein 1. (709 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (403 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
H3B0X9_LATCHUncharacterized protein. (786 aa)
FOXC2Forkhead box C2. (469 aa)
NUP133Nucleoporin 133; Belongs to the actin family. (1421 aa)
SIX2SIX homeobox 2. (289 aa)
MYOCDMyocardin. (963 aa)
H3B277_LATCHUncharacterized protein. (4290 aa)
PTCD2Pentatricopeptide repeat domain 2. (405 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
GREB1Uncharacterized protein. (1948 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2690 aa)
H3B4C9_LATCHPDZ domain-containing protein. (105 aa)
LAMB2Laminin subunit beta 2. (1781 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PYGO1Pygopus family PHD finger 1. (419 aa)
CTNNB1Catenin beta 1. (781 aa)
H3B5Z8_LATCHUncharacterized protein. (606 aa)
LOC102354417Uncharacterized protein. (723 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
BASP1Brain abundant membrane attached signal protein 1. (228 aa)
AMER1APC membrane recruitment protein 1. (900 aa)
TFAP2ETranscription factor AP-2 epsilon. (439 aa)
SULF1Sulfatase 1. (1129 aa)
HELLSHelicase, lymphoid specific. (874 aa)
WT1WT1 transcription factor. (422 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1974 aa)
SOX8SRY-box transcription factor 8. (477 aa)
HOXC11Homeobox C11. (301 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
NF1Neurofibromin 1. (2814 aa)
TNS2Tensin 2. (1731 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
H3BCG1_LATCHSET domain-containing protein. (714 aa)
AP2B1AP complex subunit beta. (952 aa)
PLCE1Phospholipase C epsilon 1. (1914 aa)
HNF1AHNF1 homeobox A. (624 aa)
IFT20Intraflagellar transport 20. (132 aa)
GCNT3Glucosaminyl (N-acetyl) transferase 3, mucin type. (420 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
LOC102354637Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a. (386 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (457 aa)
SIX4SIX homeobox 4. (742 aa)
SIX1SIX homeobox 1. (283 aa)
ZBTB16Zinc finger and BTB domain containing 16. (420 aa)
LRP4LDL receptor related protein 4. (1896 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
LOC102350297Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NUP160Nucleoporin 160. (1326 aa)
TP73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
H3BIS0_LATCHUncharacterized protein. (153 aa)
LRP2LDL receptor related protein 2. (4649 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
M3XHJ5_LATCHUncharacterized protein. (158 aa)
BMPERBMP binding endothelial regulator. (682 aa)
CENPFCentromere protein F. (3070 aa)
TTC8Tetratricopeptide repeat domain 8. (534 aa)
WDPCPWD repeat containing planar cell polarity effector. (727 aa)
RPGRIP1LRPGRIP1 like. (1318 aa)
STRA6Stimulated by retinoic acid 6. (664 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
GDNFGlial cell derived neurotrophic factor. (222 aa)
BAXUncharacterized protein. (223 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
ILKIntegrin linked kinase. (417 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FOXC1Forkhead box C1. (471 aa)
DACT2Dishevelled-binding antagonist of beta-catenin 2. (770 aa)
OSR1Odd-skipped related transcription factor 1. (259 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
OSR2Odd-skipped related transciption factor 2. (314 aa)
ANKS6Ankyrin repeat and sterile alpha motif domain containing 6. (902 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
LOC102364659G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (319 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
TCF21Transcription factor 21. (179 aa)
TSTSulfurtransferase. (301 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
NLE1Notchless homolog 1. (488 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (890 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1090 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
GLIS2GLIS family zinc finger 2. (534 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
H3A4J9_LATCHSi:dkey-88l16.3. (1142 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (348 aa)
LOC102358239TRAF3 interacting protein 2-like. (392 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4241 aa)
PAX8Paired box 8. (458 aa)
GLI3GLI family zinc finger 3. (1456 aa)
PTCH1Patched 1. (1287 aa)
MTSS1MTSS I-BAR domain containing 1. (636 aa)
BAG6BCL2 associated athanogene 6. (995 aa)
TFAP2ATranscription factor AP-2 alpha. (438 aa)
NOTCH3Notch receptor 3. (1577 aa)
CEP290Centrosomal protein 290. (2474 aa)
GATA3GATA binding protein 3. (447 aa)
CER1CTCK domain-containing protein. (257 aa)
AP1B1AP complex subunit beta. (946 aa)
H3A0S5_LATCHUncharacterized protein. (547 aa)
ENPEPAminopeptidase. (952 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
DCHS2Uncharacterized protein. (3211 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
FREM2-2Uncharacterized protein. (1618 aa)
H2ZYH3_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
H2ZX66_LATCHUncharacterized protein. (641 aa)
FREM3FRAS1 related extracellular matrix 3. (3131 aa)
ARL3ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (203 aa)
IFT88Intraflagellar transport 88. (833 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1222 aa)
H2ZUH0_LATCHUncharacterized protein. (1420 aa)
LOC102356625Dachsous cadherin-related 1a. (1697 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (625 aa)
LOC102353790Uncharacterized protein. (899 aa)
LOC102356000Uncharacterized protein. (211 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1b. (347 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
IFT27Intraflagellar transport 27. (186 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
TMEM59LTransmembrane protein 59 like. (340 aa)
NPHS2NPHS2 stomatin family member, podocin. (398 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (417 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
H3AEK5_LATCHAquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
LOC102358221G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
FREM2Uncharacterized protein. (1163 aa)
SMAD5Mothers against decapentaplegic homolog. (467 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CRLF1Cytokine receptor like factor 1. (390 aa)
H3AFZ6_LATCHFraser extracellular matrix complex subunit 1. (1615 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (285 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (361 aa)
SMAD4MH2 domain-containing protein. (412 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
FOXS1Fork-head domain-containing protein. (155 aa)
SULF2Extracellular sulfatase. (877 aa)
KANK2KN motif and ankyrin repeat domains 2. (1279 aa)
HSPB11Zgc:158640. (142 aa)
NPHP3Nephronophthisis 3. (1314 aa)
FLCNFolliculin. (576 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
HOXD11Homeobox D11. (294 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (121 aa)
H3AMW9_LATCHUncharacterized protein. (2007 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (672 aa)
PYGO2Pygopus family PHD finger 2. (401 aa)
TBC1D32TBC1 domain family member 32. (1307 aa)
BICC1BicC family RNA binding protein 1. (869 aa)
LOC102346475Uncharacterized protein. (270 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (930 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
H3AR28_LATCHUncharacterized protein. (1058 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (338 aa)
H3ARL7_LATCHFork-head domain-containing protein. (195 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1842 aa)
ZBTB14Zinc finger and BTB domain containing 14. (453 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (443 aa)
TSC1TSC complex subunit 1. (1217 aa)
CNTRLCentriolin. (2273 aa)
WFS1Wolframin ER transmembrane glycoprotein. (876 aa)
IRX3Iroquois homeobox 3. (447 aa)
TRAF3IP2SEFIR domain-containing protein. (379 aa)
LRRK2Leucine rich repeat kinase 2. (2508 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
PLXND1Plexin D1. (1875 aa)
H3AVW8_LATCHMothers against decapentaplegic homolog. (369 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (566 aa)
MAGI2Uncharacterized protein. (397 aa)
LOC102358151Angiotensin-converting enzyme. (1260 aa)
COMMD5COMM domain containing 5. (223 aa)
TSHZ1Teashirt zinc finger homeobox 1. (1043 aa)
IRX1Iroquois homeobox 1. (460 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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