(61 nodes) Nephron epithelium development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HNF1A	HNF1 homeobox A. (624 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC102350297	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	H3B277_LATCH	Uncharacterized protein. (4290 aa)
	FOXC2	Forkhead box C2. (469 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	IRX1	Iroquois homeobox 1. (460 aa)
	COMMD5	COMM domain containing 5. (223 aa)
	MAGI2	Uncharacterized protein. (397 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	IRX3	Iroquois homeobox 3. (447 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1842 aa)
	H3ARL7_LATCH	Fork-head domain-containing protein. (195 aa)
	H3AR28_LATCH	Uncharacterized protein. (1058 aa)
	FOXS1	Fork-head domain-containing protein. (155 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1222 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	H3A0S5_LATCH	Uncharacterized protein. (547 aa)
	GATA3	GATA binding protein 3. (447 aa)
	MTSS1	MTSS I-BAR domain containing 1. (636 aa)
	PTCH1	Patched 1. (1287 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	PAX8	Paired box 8. (458 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4241 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (890 aa)
	TCF21	Transcription factor 21. (179 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	FOXC1	Forkhead box C1. (471 aa)
	ILK	Integrin linked kinase. (417 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	GDNF	Glial cell derived neurotrophic factor. (222 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1b. (347 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (398 aa)
	TMEM59L	Transmembrane protein 59 like. (340 aa)
	GREB1	Uncharacterized protein. (1948 aa)
	H3B4C9_LATCH	PDZ domain-containing protein. (105 aa)
	LAMB2	Laminin subunit beta 2. (1781 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	H3B5Z8_LATCH	Uncharacterized protein. (606 aa)
	LOC102354417	Uncharacterized protein. (723 aa)
	BASP1	Brain abundant membrane attached signal protein 1. (228 aa)
	WT1	WT1 transcription factor. (422 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1974 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP11	H3AEK5_LATCH	ENSLACP00000007328	ENSLACP00000008076	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.615
BASP1	WT1	ENSLACP00000017621	ENSLACP00000018599	Brain abundant membrane attached signal protein 1.	WT1 transcription factor.	0.543
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF2	ENSLACP00000016168	ENSLACP00000019200	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.451
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP2	GREM1	ENSLACP00000016168	ENSLACP00000007025	Bone morphogenetic protein 2.	Gremlin 1, DAN family BMP antagonist.	0.717
BMP2	LOC102358988	ENSLACP00000016168	ENSLACP00000022115	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.711
BMP2	SMAD4	ENSLACP00000016168	ENSLACP00000009312	Bone morphogenetic protein 2.	MH2 domain-containing protein.	0.711
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499
BMP4	FGF2	ENSLACP00000021723	ENSLACP00000019200	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.520
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
BMP4	GLI3	ENSLACP00000021723	ENSLACP00000004224	Bone morphogenetic protein 4.	GLI family zinc finger 3.	0.444
BMP4	GREM1	ENSLACP00000021723	ENSLACP00000007025	Bone morphogenetic protein 4.	Gremlin 1, DAN family BMP antagonist.	0.717
BMP4	LOC102358988	ENSLACP00000021723	ENSLACP00000022115	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.711
BMP4	PTCH1	ENSLACP00000021723	ENSLACP00000004070	Bone morphogenetic protein 4.	Patched 1.	0.605
BMP4	SMAD4	ENSLACP00000021723	ENSLACP00000009312	Bone morphogenetic protein 4.	MH2 domain-containing protein.	0.815
CTNNB1	CTNNBIP1	ENSLACP00000017209	ENSLACP00000007182	Catenin beta 1.	Catenin beta interacting protein 1.	0.999
CTNNB1	FGF8	ENSLACP00000017209	ENSLACP00000007843	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437