(7 nodes) Proximal tubule development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4241 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	COMMD5	COMM domain containing 5. (223 aa)
	H3B277_LATCH	Uncharacterized protein. (4290 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP11	H3AEK5_LATCH	ENSLACP00000007328	ENSLACP00000008076	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.615
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
H3AEK5_LATCH	AQP11	ENSLACP00000008076	ENSLACP00000007328	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.615