(36 nodes) Stem cell proliferation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRIM71	Tripartite motif containing 71. (841 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	BABAM1	BRISC and BRCA1 A complex member 1. (323 aa)
	CEP120	Centrosomal protein 120. (499 aa)
	H3AGP4_LATCH	Tower domain-containing protein. (1245 aa)
	SART3	Spliceosome associated factor 3, U4/U6 recycling protein. (720 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	XRCC5	X-ray repair cross complementing 5. (606 aa)
	SCRG1	Stimulator of chondrogenesis 1. (98 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (169 aa)
	YJEFN3	YjeF N-terminal domain containing 3. (202 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	PTCH1	Patched 1. (1287 aa)
	LIG4	DNA ligase. (911 aa)
	ETV6	ETS variant 6. (470 aa)
	LOC102366946	Uncharacterized protein. (358 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	TP63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	ERCC2	ERCC excision repair 2, TFIIH core complex helicase subunit. (611 aa)
	ZNRF3-2	Uncharacterized protein. (79 aa)
	HOXB4	Homeobox domain-containing protein. (247 aa)
	H3B5P8_LATCH	ZNRF_3_ecto domain-containing protein. (60 aa)
	ZNRF3	Zinc and ring finger 3. (698 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (477 aa)
	RNF43	RING-type domain-containing protein. (626 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	NF1	Neurofibromin 1. (2814 aa)
	MECOM	MDS1 and EVI1 complex locus. (1117 aa)
	HOXA3	Homeobox A3. (411 aa)
	IFT20	Intraflagellar transport 20. (132 aa)
	LOC102348669	B box-type domain-containing protein. (585 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	KDF1	Keratinocyte differentiation factor 1. (380 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP120	LOC102366946	ENSLACP00000010056	ENSLACP00000001955	Centrosomal protein 120.	Uncharacterized protein.	0.935
ERCC2	H3AGP4_LATCH	ENSLACP00000016071	ENSLACP00000008815	ERCC excision repair 2, TFIIH core complex helicase subunit.	Tower domain-containing protein.	0.639
ERCC2	LIG4	ENSLACP00000016071	ENSLACP00000003688	ERCC excision repair 2, TFIIH core complex helicase subunit.	DNA ligase.	0.560
ERCC2	TP53	ENSLACP00000016071	ENSLACP00000015915	ERCC excision repair 2, TFIIH core complex helicase subunit.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.478
ERCC2	XRCC5	ENSLACP00000016071	ENSLACP00000006859	ERCC excision repair 2, TFIIH core complex helicase subunit.	X-ray repair cross complementing 5.	0.559
FGF2	FGF4	ENSLACP00000019200	ENSLACP00000014225	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
FGF2	KDR	ENSLACP00000019200	ENSLACP00000011126	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.879
FGF2	TGFB1	ENSLACP00000019200	ENSLACP00000020652	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.577
FGF4	FGF2	ENSLACP00000014225	ENSLACP00000019200	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
FGF4	FGF8	ENSLACP00000014225	ENSLACP00000007843	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
FGF4	GLI3	ENSLACP00000014225	ENSLACP00000004224	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.472
FGF4	KDR	ENSLACP00000014225	ENSLACP00000011126	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.837
FGF4	TGFB1	ENSLACP00000014225	ENSLACP00000020652	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.507
FGF8	FGF4	ENSLACP00000007843	ENSLACP00000014225	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.724
FGF8	GLI3	ENSLACP00000007843	ENSLACP00000004224	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.634
FGF8	KDR	ENSLACP00000007843	ENSLACP00000011126	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.823
FGF8	PTCH1	ENSLACP00000007843	ENSLACP00000004070	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Patched 1.	0.554
FGF8	TGFB1	ENSLACP00000007843	ENSLACP00000020652	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.476
FGF8	WNT1	ENSLACP00000007843	ENSLACP00000021628	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.716
GLI3	FGF4	ENSLACP00000004224	ENSLACP00000014225	GLI family zinc finger 3.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472