(47 nodes) Signal transduction by p53 class mediator network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BATF	Basic leucine zipper ATF-like transcription factor. (119 aa)
	CHEK2	Checkpoint kinase 2. (411 aa)
	TMEM109	Uncharacterized protein. (257 aa)
	TFAP4	Transcription factor AP-4. (350 aa)
	H2ZSY2_LATCH	Uncharacterized protein. (345 aa)
	LOC102360187	MutS homolog 2 (E. coli). (447 aa)
	RRP8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (469 aa)
	H2ZX83_LATCH	MutS homolog 2 (E. coli). (360 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (269 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (433 aa)
	BAG6	BCL2 associated athanogene 6. (995 aa)
	BAX	Uncharacterized protein. (223 aa)
	E2F1	E2F transcription factor 1. (411 aa)
	H3AGP4_LATCH	Tower domain-containing protein. (1245 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase. (752 aa)
	FOXM1	Forkhead box M1. (541 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1230 aa)
	BOK	BCL2 family apoptosis regulator BOK. (111 aa)
	H3AJV2_LATCH	PHD-type domain-containing protein. (679 aa)
	E2F2	E2F transcription factor 2. (435 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (226 aa)
	NDRG1	N-myc downstream regulated 1. (402 aa)
	ATRX	ATRX chromatin remodeler. (2488 aa)
	ZNF385B	Zinc finger protein 385B. (393 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (864 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	SNW1	SNW domain containing 1. (536 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	E2F7	Uncharacterized protein. (373 aa)
	CDIP1	Cell death inducing p53 target 1. (210 aa)
	WWOX	WW domain containing oxidoreductase. (353 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
	H3B863_LATCH	U1-type domain-containing protein. (114 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (636 aa)
	ATAD5	ATPase family AAA domain containing 5. (1828 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
	DDIT4	DNA damage inducible transcript 4. (222 aa)
	WHAMM	WASP homolog associated with actin, golgi membranes and microtubules. (768 aa)
	MYBBP1A	MYB binding protein 1a. (1272 aa)
	TP73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	TP63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	GTSE1	GTSE1_N domain-containing protein. (721 aa)
	TP53BP2	Tumor protein p53 binding protein 2. (1194 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (143 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CHEK2	ENSLACP00000019203	ENSLACP00000000143	ATPase family AAA domain containing 5.	Checkpoint kinase 2.	0.564
ATAD5	H3AGP4_LATCH	ENSLACP00000019203	ENSLACP00000008815	ATPase family AAA domain containing 5.	Tower domain-containing protein.	0.694
ATRX	H3AGP4_LATCH	ENSLACP00000011544	ENSLACP00000008815	ATRX chromatin remodeler.	Tower domain-containing protein.	0.425
ATRX	TP53	ENSLACP00000011544	ENSLACP00000015915	ATRX chromatin remodeler.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.596
BAX	LOC102349920	ENSLACP00000007049	ENSLACP00000010067	Uncharacterized protein.	Uncharacterized protein.	0.458
BAX	TP53	ENSLACP00000007049	ENSLACP00000015915	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.780
CASP2	CRADD	ENSLACP00000002990	ENSLACP00000023466	Caspase 2; Belongs to the peptidase C14A family.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.962
CASP2	TP53	ENSLACP00000002990	ENSLACP00000015915	Caspase 2; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.512
CASP6	CRADD	ENSLACP00000002246	ENSLACP00000023466	Caspase 6; Belongs to the peptidase C14A family.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.459
CASP6	TP53	ENSLACP00000002246	ENSLACP00000015915	Caspase 6; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.548
CDIP1	DDX5	ENSLACP00000016732	ENSLACP00000017080	Cell death inducing p53 target 1.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.542
CHEK2	ATAD5	ENSLACP00000000143	ENSLACP00000019203	Checkpoint kinase 2.	ATPase family AAA domain containing 5.	0.564
CHEK2	H2ZX83_LATCH	ENSLACP00000000143	ENSLACP00000002004	Checkpoint kinase 2.	MutS homolog 2 (E. coli).	0.569
CHEK2	H3AGP4_LATCH	ENSLACP00000000143	ENSLACP00000008815	Checkpoint kinase 2.	Tower domain-containing protein.	0.764
CHEK2	LOC102360187	ENSLACP00000000143	ENSLACP00000000628	Checkpoint kinase 2.	MutS homolog 2 (E. coli).	0.569
CHEK2	MDM4	ENSLACP00000000143	ENSLACP00000019637	Checkpoint kinase 2.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.856
CHEK2	PPM1D	ENSLACP00000000143	ENSLACP00000019083	Checkpoint kinase 2.	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	0.675
CHEK2	SIRT1	ENSLACP00000000143	ENSLACP00000009079	Checkpoint kinase 2.	Sirtuin 1.	0.470
CHEK2	TP53	ENSLACP00000000143	ENSLACP00000015915	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.995
CHEK2	TP63	ENSLACP00000000143	ENSLACP00000022643	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.787