STRINGSTRING
H2ZRM4_LATCH H2ZRM4_LATCH LOC102350617 LOC102350617 H2ZSK5_LATCH H2ZSK5_LATCH CHRD CHRD H2ZTV2_LATCH H2ZTV2_LATCH CSNK2B CSNK2B LOC102351518 LOC102351518 LOC102356560 LOC102356560 LOC102353315 LOC102353315 LRG1 LRG1 LOC102363464 LOC102363464 LOC102354291 LOC102354291 VEPH1-2 VEPH1-2 DLX1 DLX1 BMP3 BMP3 BMP10 BMP10 ACVR2A ACVR2A LOC102350164 LOC102350164 CER1 CER1 RNF111 RNF111 CILP2 CILP2 TGFBR2 TGFBR2 MSX1 MSX1 ITGA3 ITGA3 TNFAIP6 TNFAIP6 WFIKKN2 WFIKKN2 LOC102356523 LOC102356523 LOC102358266 LOC102358266 INHBA INHBA SPART SPART SMAD6 SMAD6 SNX25 SNX25 ZNF451 ZNF451 GDF7 GDF7 SMAD7 SMAD7 DACT2 DACT2 GDF6 GDF6 ILK ILK GREM1 GREM1 LOC102352233 LOC102352233 TGFBR3 TGFBR3 FKBP8 FKBP8 SFRP2 SFRP2 TGFB2 TGFB2 CCN3 CCN3 BAMBI BAMBI IL17F IL17F TGFBR1 TGFBR1 LINGO3 LINGO3 LOC102350487 LOC102350487 SMAD2 SMAD2 NRROS NRROS RNF165 RNF165 NOG NOG LOC102351081 LOC102351081 SIRT1 SIRT1 LOC102352539 LOC102352539 SMAD4 SMAD4 STRAP STRAP LOC102357009 LOC102357009 TWSG1 TWSG1 SFRP1 SFRP1 LATS2 LATS2 SKOR2 SKOR2 SLC2A10 SLC2A10 FBN1 FBN1 ADAMTSL2 ADAMTSL2 FAM89B FAM89B GDF5 GDF5 ADAM17 ADAM17 FSTL3 FSTL3 FLCN FLCN EMILIN1 EMILIN1 KDR KDR MPP5 MPP5 SFRP1-2 SFRP1-2 IL17RD IL17RD LATS1 LATS1 BMP5 BMP5 ACVR1 ACVR1 LEMD3 LEMD3 CHRDL1 CHRDL1 NBL1 NBL1 ZBTB7A ZBTB7A SOST SOST LDLRAD4 LDLRAD4 SMAD3 SMAD3 HTRA3 HTRA3 TBX20 TBX20 C20orf27 C20orf27 SORL1 SORL1 SOSTDC1 SOSTDC1 CTDSPL2 CTDSPL2 BMP6 BMP6 PPARA PPARA NUP93 NUP93 CDH5 CDH5 NUMA1 NUMA1 LOC102357384 LOC102357384 STK11 STK11 SPRED1 SPRED1 LOC102358054 LOC102358054 KIAA1324L KIAA1324L CHST11 CHST11 LOC102358352 LOC102358352 ACVR2B ACVR2B H3AVW8_LATCH H3AVW8_LATCH HJV HJV LOC102348675 LOC102348675 FST FST CAV2 CAV2 ZNF423 ZNF423 CAV1 CAV1 ING2 ING2 MAGI2 MAGI2 DAB2 DAB2 GIPC2 GIPC2 ZEB1 ZEB1 SNW1 SNW1 BMP15 BMP15 GREM2 GREM2 VEPH1 VEPH1 SKI SKI PBLD PBLD BBIP1 BBIP1 SFRP5 SFRP5 TP53 TP53 MYOCD MYOCD BMP2 BMP2 SKOR1 SKOR1 GDF3 GDF3 WFIKKN1 WFIKKN1 SMURF2 SMURF2 VWC2 VWC2 SKIL SKIL H3B4C9_LATCH H3B4C9_LATCH ISM2 ISM2 BMPR2 BMPR2 GIPC3 GIPC3 INHA INHA SPRY1 SPRY1 DAND5 DAND5 VWC2L VWC2L INHBB INHBB SULF1 SULF1 NODAL NODAL H3B924_LATCH H3B924_LATCH GDF2 GDF2 LOC102356742 LOC102356742 GDF10 GDF10 LEMD2 LEMD2 TGFB3 TGFB3 GIPC1 GIPC1 CILP CILP H3BB14_LATCH H3BB14_LATCH LOC102355199 LOC102355199 FBXL15 FBXL15 LOC102352268 LOC102352268 BCL9L BCL9L CCN1 CCN1 HOXA13 HOXA13 LOC102361854 LOC102361854 BMP7 BMP7 CRIM1 CRIM1 H3BE69_LATCH H3BE69_LATCH H3BEX6_LATCH H3BEX6_LATCH PMEPA1 PMEPA1 TGFB1 TGFB1 THBS1 THBS1 HSPA5 HSPA5 CAV3 CAV3 SPRED3 SPRED3 PPM1A PPM1A ZNF703 ZNF703 ARID4A ARID4A PRDM16-2 PRDM16-2 WNT1 WNT1 PRDM16 PRDM16 LOC102355609 LOC102355609 LOC102355877 LOC102355877 BMP4 BMP4 ACVRL1 ACVRL1 ACVR1B ACVR1B H3BIS0_LATCH H3BIS0_LATCH RBPMS2 RBPMS2 LOC102358988 LOC102358988 BMPER BMPER LOC102356233 LOC102356233 UBE2O UBE2O ENG ENG CREBBP CREBBP M3XLP3_LATCH M3XLP3_LATCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2ZRM4_LATCHUncharacterized protein. (379 aa)
LOC102350617Uncharacterized protein. (222 aa)
H2ZSK5_LATCHUncharacterized protein. (528 aa)
CHRDChordin; Belongs to the chordin family. (948 aa)
H2ZTV2_LATCHUncharacterized protein. (383 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (148 aa)
LOC102351518Left-right determination factor. (364 aa)
LOC102356560ANK_REP_REGION domain-containing protein. (128 aa)
LOC102353315Uncharacterized protein. (381 aa)
LRG1LRRCT domain-containing protein. (337 aa)
LOC102363464Si:ch211-267e7.3. (924 aa)
LOC102354291Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
VEPH1-2Uncharacterized protein. (196 aa)
DLX1Distal-less homeobox 1. (253 aa)
BMP3Bone morphogenetic protein 3. (365 aa)
BMP10Bone morphogenetic protein 10. (405 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
LOC102350164Uncharacterized protein. (364 aa)
CER1CTCK domain-containing protein. (257 aa)
RNF111Ring finger protein 111. (966 aa)
CILP2Cartilage intermediate layer protein 2. (1075 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
MSX1Msh homeobox 1. (256 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
TNFAIP6TNF alpha induced protein 6. (279 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
LOC102356523Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
LOC102358266Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
INHBAInhibin subunit beta A. (390 aa)
SPARTSpartin. (664 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
SNX25Sorting nexin 25. (620 aa)
ZNF451Zinc finger protein 451. (1068 aa)
GDF7Growth differentiation factor 7. (416 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
DACT2Dishevelled-binding antagonist of beta-catenin 2. (770 aa)
GDF6Growth differentiation factor 6a. (408 aa)
ILKIntegrin linked kinase. (417 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
LOC102352233Uncharacterized protein. (511 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
FKBP8Peptidylprolyl isomerase. (443 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
CCN3Cellular communication network factor 3. (345 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
IL17FInterleukin 17F. (166 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
LINGO3Leucine rich repeat and Ig domain containing 3a. (624 aa)
LOC102350487RGM domain family, member D. (443 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
RNF165Ring finger protein 165. (351 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
SIRT1Sirtuin 1. (729 aa)
LOC102352539Uncharacterized protein. (949 aa)
SMAD4MH2 domain-containing protein. (412 aa)
STRAPSerine/threonine kinase receptor associated protein. (329 aa)
LOC102357009Southpaw. (414 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (220 aa)
SFRP1NTR domain-containing protein. (128 aa)
LATS2Large tumor suppressor kinase 2. (1108 aa)
SKOR2SKI family transcriptional corepressor 2. (721 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (535 aa)
FBN1Fibrillin 1. (2872 aa)
ADAMTSL2ADAMTS like 2. (952 aa)
FAM89BFamily with sequence similarity 89 member B. (179 aa)
GDF5Growth differentiation factor 5. (501 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
FSTL3Follistatin like 3. (248 aa)
FLCNFolliculin. (576 aa)
EMILIN1Elastin microfibril interfacer 1. (1047 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (678 aa)
SFRP1-2FZ domain-containing protein. (203 aa)
IL17RDInterleukin 17 receptor D. (698 aa)
LATS1Large tumor suppressor kinase 1. (1140 aa)
BMP5Bone morphogenetic protein 5. (131 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
LEMD3LEM domain containing 3. (705 aa)
CHRDL1Chordin like 1. (458 aa)
NBL1NBL1, DAN family BMP antagonist. (184 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (518 aa)
SOSTSclerostin. (210 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (310 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
HTRA3HtrA serine peptidase 3. (460 aa)
TBX20T-box transcription factor 20. (441 aa)
C20orf27Chromosome 20 open reading frame 27. (106 aa)
SORL1Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
SOSTDC1Sclerostin domain containing 1. (213 aa)
CTDSPL2FCP1 homology domain-containing protein. (2335 aa)
BMP6Bone morphogenetic protein 6. (428 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (722 aa)
CDH5Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2155 aa)
LOC102357384Noggin; Belongs to the noggin family. (216 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
LOC102358054Bone morphogenetic protein 8a. (420 aa)
KIAA1324LKIAA1324 like. (965 aa)
CHST11Carbohydrate sulfotransferase. (298 aa)
LOC102358352TGF_BETA_2 domain-containing protein. (365 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
H3AVW8_LATCHMothers against decapentaplegic homolog. (369 aa)
HJVHemojuvelin BMP co-receptor. (404 aa)
LOC102348675Nodal modulator. (1131 aa)
FSTFollistatin. (319 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
ZNF423Zinc finger protein 423. (1277 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ING2Inhibitor of growth protein. (269 aa)
MAGI2Uncharacterized protein. (397 aa)
DAB2DAB adaptor protein 2. (745 aa)
GIPC2GIPC PDZ domain containing family member 2. (327 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1076 aa)
SNW1SNW domain containing 1. (536 aa)
BMP15Bone morphogenetic protein 15. (394 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (167 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (528 aa)
SKISKI proto-oncogene. (702 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
BBIP1Uncharacterized protein. (499 aa)
SFRP5Secreted frizzled related protein 5. (309 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
MYOCDMyocardin. (963 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
SKOR1SKI family transcriptional corepressor 1. (787 aa)
GDF3Growth differentiation factor 3. (381 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (556 aa)
SMURF2E3 ubiquitin-protein ligase. (754 aa)
VWC2Von Willebrand factor C domain containing 2. (270 aa)
SKILSKI like proto-oncogene. (691 aa)
H3B4C9_LATCHPDZ domain-containing protein. (105 aa)
ISM2Isthmin 2a. (408 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
GIPC3GIPC PDZ domain containing family member 3. (319 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (345 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
DAND5CTCK domain-containing protein. (247 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (176 aa)
INHBBInhibin subunit beta B. (393 aa)
SULF1Sulfatase 1. (1129 aa)
NODALTGF_BETA_2 domain-containing protein. (409 aa)
H3B924_LATCHTGF_BETA_2 domain-containing protein. (356 aa)
GDF2Growth differentiation factor 2. (431 aa)
LOC102356742Sizzled. (295 aa)
GDF10Growth differentiation factor 10. (440 aa)
LEMD2LEM domain containing 2. (416 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
CILPCartilage intermediate layer protein. (1183 aa)
H3BB14_LATCHUncharacterized protein. (123 aa)
LOC102355199Uncharacterized protein. (301 aa)
FBXL15F-box and leucine rich repeat protein 15. (302 aa)
LOC102352268Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
BCL9LBCL9 like. (1514 aa)
CCN1Cellular communication network factor 1. (368 aa)
HOXA13Homeobox A13b. (295 aa)
LOC102361854Anti-dorsalizing morphogenic protein. (394 aa)
BMP7Bone morphogenetic protein 7. (425 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (881 aa)
H3BE69_LATCHPID domain-containing protein. (136 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (284 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
THBS1Thrombospondin 1. (1170 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
SPRED3Sprouty related EVH1 domain containing 3. (453 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
ZNF703Zinc finger protein 703. (539 aa)
ARID4AAT-rich interaction domain 4A. (1297 aa)
PRDM16-2Si:ch211-263k4.2. (114 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
PRDM16PR/SET domain 16. (1135 aa)
LOC102355609TGF_BETA_2 domain-containing protein. (385 aa)
LOC102355877TGF_BETA_2 domain-containing protein. (359 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
H3BIS0_LATCHUncharacterized protein. (153 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (227 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
BMPERBMP binding endothelial regulator. (682 aa)
LOC102356233TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1313 aa)
ENGEndoglin. (674 aa)
CREBBPCREB binding protein. (2411 aa)
M3XLP3_LATCHUncharacterized protein. (408 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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