(54 nodes) Tissue migration network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	S100Z	Protein S100; Belongs to the S-100 family. (123 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	EFNB2	Ephrin B2; Belongs to the ephrin family. (338 aa)
	LTB4R2	Leukotriene B4 receptor 2; Belongs to the G-protein coupled receptor 1 family. (349 aa)
	H3APT2_LATCH	PH domain-containing protein. (309 aa)
	H3ANL8_LATCH	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family. (755 aa)
	LOXL4	Lysyl oxidase like 4. (765 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	VSTM4	V-set and transmembrane domain containing 4. (328 aa)
	KANK2	KN motif and ankyrin repeat domains 2. (1279 aa)
	PRKX	Protein kinase X-linked; Belongs to the protein kinase superfamily. (285 aa)
	PKN2	Protein kinase N2. (993 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	CCN3	Cellular communication network factor 3. (345 aa)
	H3AC70_LATCH	LRRNT domain-containing protein. (132 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	LOC102359111	Nanos homolog 1; Belongs to the nanos family. (224 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	MMRN2	Multimerin 2. (911 aa)
	ARSJ	Arylsulfatase family member J. (468 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
	LRG1	LRRCT domain-containing protein. (337 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (357 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)
	ADTRP	Uncharacterized protein. (229 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (727 aa)
	LOC102357431	Uncharacterized protein. (397 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (580 aa)
	H3BH52_LATCH	PH domain-containing protein. (453 aa)
	ARSB	Arylsulfatase B. (532 aa)
	LGALS8	Galectin. (356 aa)
	LOC102349421	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (333 aa)
	LOC102362765	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	PTPN9	Protein tyrosine phosphatase non-receptor type 9. (582 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (396 aa)
	ARSI	Arylsulfatase family member I. (572 aa)
	H3B752_LATCH	Sulfatase domain-containing protein. (131 aa)
	PKN1	Uncharacterized protein. (546 aa)
	NANOS1	Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (213 aa)
	GIPC3	GIPC PDZ domain containing family member 3. (319 aa)
	H3B4R6_LATCH	Uncharacterized protein. (956 aa)
	FSTL1	Follistatin like 1. (261 aa)
	SRF	Serum response factor. (520 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (506 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	TESK1	Testis associated actin remodelling kinase 1. (600 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (327 aa)
	PLXND1	Plexin D1. (1875 aa)
	H3AVL9_LATCH	Lysyl oxidase-like 3b. (475 aa)
	LOXL2	Lysyl oxidase like 2. (773 aa)
	CDH5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSJ	H3B752_LATCH	ENSLACP00000002654	ENSLACP00000017723	Arylsulfatase family member J.	Sulfatase domain-containing protein.	0.951
CDH5	KDR	ENSLACP00000012760	ENSLACP00000011126	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.824
CDH5	NRP1	ENSLACP00000012760	ENSLACP00000023533	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Neuropilin; Belongs to the neuropilin family.	0.420
EFNB2	NRP1	ENSLACP00000012268	ENSLACP00000023533	Ephrin B2; Belongs to the ephrin family.	Neuropilin; Belongs to the neuropilin family.	0.497
FGF8	KDR	ENSLACP00000007843	ENSLACP00000011126	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.823
FGF8	KIT	ENSLACP00000007843	ENSLACP00000004383	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.778
FGF8	NRP1	ENSLACP00000007843	ENSLACP00000023533	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Neuropilin; Belongs to the neuropilin family.	0.470
GIPC1	NRP1	ENSLACP00000018994	ENSLACP00000023533	GIPC PDZ domain containing family member 1.	Neuropilin; Belongs to the neuropilin family.	0.806
GIPC1	PLXND1	ENSLACP00000018994	ENSLACP00000013783	GIPC PDZ domain containing family member 1.	Plexin D1.	0.501
GIPC2	PLXND1	ENSLACP00000014826	ENSLACP00000013783	GIPC PDZ domain containing family member 2.	Plexin D1.	0.501
GIPC3	PLXND1	ENSLACP00000017169	ENSLACP00000013783	GIPC PDZ domain containing family member 3.	Plexin D1.	0.501
H3AC70_LATCH	SLIT2	ENSLACP00000007241	ENSLACP00000012299	LRRNT domain-containing protein.	Slit guidance ligand 2.	0.900
H3APT2_LATCH	ROCK1	ENSLACP00000011653	ENSLACP00000016034	PH domain-containing protein.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.472
H3B4R6_LATCH	ROCK1	ENSLACP00000016887	ENSLACP00000016034	Uncharacterized protein.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.479
H3B752_LATCH	ARSJ	ENSLACP00000017723	ENSLACP00000002654	Sulfatase domain-containing protein.	Arylsulfatase family member J.	0.951
H3BH52_LATCH	ROCK1	ENSLACP00000021223	ENSLACP00000016034	PH domain-containing protein.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.472
KDR	CDH5	ENSLACP00000011126	ENSLACP00000012760	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.824
KDR	FGF8	ENSLACP00000011126	ENSLACP00000007843	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.823
KDR	NRP1	ENSLACP00000011126	ENSLACP00000023533	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Neuropilin; Belongs to the neuropilin family.	0.934
KDR	ROCK1	ENSLACP00000011126	ENSLACP00000016034	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.498