(59 nodes) Positive regulation of canonical Wnt signaling pathway network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CAPRIN2	Caprin family member 2. (1014 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1102 aa)
	LRRK1	Leucine rich repeat kinase 1. (1987 aa)
	LOC102364406	Uncharacterized protein. (530 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (625 aa)
	LOC102352836	RNF220 domain-containing protein. (296 aa)
	DLX5	Distal-less homeobox 5. (290 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1174 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1311 aa)
	H3A657_LATCH	PH domain-containing protein. (1101 aa)
	NLE1	Notchless homolog 1. (488 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (112 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (635 aa)
	WLS	Wnt ligand secretion mediator. (541 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (212 aa)
	ILK	Integrin linked kinase. (417 aa)
	LOC102353587	Uncharacterized protein. (490 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
	RNF146	Ring finger protein 146. (347 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (952 aa)
	CSNK1E	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (418 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1233 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (367 aa)
	RSPO3	R-spondin 3. (213 aa)
	LYPD6	LY6/PLAUR domain containing 6. (171 aa)
	RNF220	Ring finger protein 220. (231 aa)
	LOC102363322	Uncharacterized protein. (509 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1381 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (223 aa)
	H3AUD4_LATCH	PPM-type phosphatase domain-containing protein. (321 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2787 aa)
	PPM1B	PPM-type phosphatase domain-containing protein. (474 aa)
	CSNK1G2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (458 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa)
	H3AZB0_LATCH	Glypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (263 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
	CSNK1D	Casein kinase 1 delta. (417 aa)
	FAM53B	Family with sequence similarity 53 member B. (292 aa)
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (456 aa)
	AMER1	APC membrane recruitment protein 1. (900 aa)
	TMEM198	Transmembrane protein 198. (365 aa)
	LOC102357497	DUF4203 domain-containing protein. (354 aa)
	PRDM15	PR/SET domain 15. (1169 aa)
	WNK2	WNK lysine deficient protein kinase 2. (1994 aa)
	XIAP	X-linked inhibitor of apoptosis. (606 aa)
	GID8	GID complex subunit 8 homolog. (190 aa)
	RSPO1	R-spondin 1. (249 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	H3BCC2_LATCH	Uncharacterized protein. (314 aa)
	LOC102354118	Dickkopf_N domain-containing protein. (243 aa)
	TMEM9	Transmembrane protein 9. (191 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (270 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (815 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (2994 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	BAMBI	ENSLACP00000005211	ENSLACP00000007870	Aryl hydrocarbon receptor nuclear translocator like.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.438
ARNTL	CSNK1D	ENSLACP00000005211	ENSLACP00000015913	Aryl hydrocarbon receptor nuclear translocator like.	Casein kinase 1 delta.	0.849
ARNTL	CSNK1E	ENSLACP00000005211	ENSLACP00000009077	Aryl hydrocarbon receptor nuclear translocator like.	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily.	0.849
BAMBI	ARNTL	ENSLACP00000007870	ENSLACP00000005211	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Aryl hydrocarbon receptor nuclear translocator like.	0.438
CSNK1D	ARNTL	ENSLACP00000015913	ENSLACP00000005211	Casein kinase 1 delta.	Aryl hydrocarbon receptor nuclear translocator like.	0.849
CSNK1E	ARNTL	ENSLACP00000009077	ENSLACP00000005211	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily.	Aryl hydrocarbon receptor nuclear translocator like.	0.849
DKK2	SFRP2	ENSLACP00000006397	ENSLACP00000007301	Dickkopf WNT signaling pathway inhibitor 2.	Secreted frizzled related protein 2.	0.536
H3AUD4_LATCH	PPM1A	ENSLACP00000013255	ENSLACP00000021184	PPM-type phosphatase domain-containing protein.	Protein phosphatase, Mg2+/Mn2+ dependent 1A.	0.901
LGR4	LGR5	ENSLACP00000013735	ENSLACP00000000237	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 5.	0.734
LGR4	RSPO1	ENSLACP00000013735	ENSLACP00000019250	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 1.	0.998
LGR4	RSPO3	ENSLACP00000013735	ENSLACP00000009679	Leucine rich repeat containing G protein-coupled receptor 4.	R-spondin 3.	0.987
LGR5	LGR4	ENSLACP00000000237	ENSLACP00000013735	Leucine rich repeat containing G protein-coupled receptor 5.	Leucine rich repeat containing G protein-coupled receptor 4.	0.734
LGR5	RSPO1	ENSLACP00000000237	ENSLACP00000019250	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 1.	0.975
LGR5	RSPO3	ENSLACP00000000237	ENSLACP00000009679	Leucine rich repeat containing G protein-coupled receptor 5.	R-spondin 3.	0.832
LOC102352836	RNF220	ENSLACP00000000545	ENSLACP00000010418	RNF220 domain-containing protein.	Ring finger protein 220.	0.900
LOC102357497	XIAP	ENSLACP00000017947	ENSLACP00000018655	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.435
LOC102363322	TBL1XR1	ENSLACP00000011640	ENSLACP00000019311	Uncharacterized protein.	Transducin beta like 1 X-linked receptor 1.	0.900
LOC102364406	RNF146	ENSLACP00000000127	ENSLACP00000008306	Uncharacterized protein.	Ring finger protein 146.	0.525
LOC102364406	TNKS	ENSLACP00000000127	ENSLACP00000009201	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.475
LOC102364406	TNKS2	ENSLACP00000000127	ENSLACP00000003297	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.502