STRINGSTRING
DSTYK DSTYK H2ZRM4_LATCH H2ZRM4_LATCH LOC102350617 LOC102350617 H2ZTF7_LATCH H2ZTF7_LATCH CHRD CHRD CCBE1 CCBE1 DCN DCN LOC102356560 LOC102356560 LOC102353315 LOC102353315 LRG1 LRG1 LOC102363464 LOC102363464 FZD4 FZD4 LOC102354291 LOC102354291 VEPH1-2 VEPH1-2 DLX1 DLX1 LOC102349535 LOC102349535 LOC102350164 LOC102350164 MMRN2 MMRN2 CER1 CER1 GATA3 GATA3 RNF111 RNF111 FAM20C FAM20C TMEM204 TMEM204 PTPN1 PTPN1 MSX1 MSX1 ITGA3 ITGA3 TNFAIP6 TNFAIP6 WFIKKN2 WFIKKN2 LRIT3 LRIT3 LOC102358266 LOC102358266 PRDM14 PRDM14 SPART SPART SMAD6 SMAD6 SNX25 SNX25 ZNF451 ZNF451 LOC102356182 LOC102356182 SMAD7 SMAD7 ILK ILK JCAD JCAD GREM1 GREM1 LOC102352233 LOC102352233 H3AC70_LATCH H3AC70_LATCH TGFBR3 TGFBR3 FKBP8 FKBP8 SFRP2 SFRP2 BAMBI BAMBI IL17F IL17F LINGO3 LINGO3 LOC102350487 LOC102350487 SMAD2 SMAD2 NRROS NRROS RNF165 RNF165 NOG NOG DLL3 DLL3 LOC102351081 LOC102351081 SIRT1 SIRT1 LOC102352539 LOC102352539 SMAD4 SMAD4 STRAP STRAP DLL1 DLL1 SULF2 SULF2 TWSG1 TWSG1 SFRP1 SFRP1 LATS2 LATS2 SKOR2 SKOR2 SLC2A10 SLC2A10 FBN1 FBN1 ADAMTSL2 ADAMTSL2 FAM89B FAM89B ADAM17 ADAM17 AGTR2 AGTR2 FSTL3 FSTL3 FLCN FLCN EMILIN1 EMILIN1 MYO1C MYO1C KDR KDR MPP5 MPP5 SFRP1-2 SFRP1-2 SPRY2 SPRY2 IL17RD IL17RD LATS1 LATS1 CASK CASK LEMD3 LEMD3 CHRDL1 CHRDL1 NBL1 NBL1 ZBTB7A ZBTB7A SOST SOST LDLRAD4 LDLRAD4 SMAD3 SMAD3 HTRA3 HTRA3 TBX20 TBX20 C20orf27 C20orf27 SLIT2 SLIT2 SORL1 SORL1 SOSTDC1 SOSTDC1 CTDSPL2 CTDSPL2 PPARA PPARA CDH5 CDH5 NUMA1 NUMA1 LOC102357384 LOC102357384 STK11 STK11 SPRED1 SPRED1 KIAA1324L KIAA1324L ATP2B4 ATP2B4 CHST11 CHST11 H3AVW8_LATCH H3AVW8_LATCH HJV HJV FST FST CAV2 CAV2 ZNF423 ZNF423 SPRY4 SPRY4 CAV1 CAV1 FGF4 FGF4 SPRY3 SPRY3 ING2 ING2 TSPAN12 TSPAN12 DAB2 DAB2 GIPC2 GIPC2 PIK3CB PIK3CB ZEB1 ZEB1 SNW1 SNW1 FGF1 FGF1 GREM2 GREM2 VEPH1 VEPH1 SKI SKI PBLD PBLD FGF18 FGF18 BBIP1 BBIP1 SFRP5 SFRP5 TP53 TP53 MYOCD MYOCD LOC102360711 LOC102360711 BMP2 BMP2 SKOR1 SKOR1 HHIP HHIP WFIKKN1 WFIKKN1 TMEM108 TMEM108 SMURF2 SMURF2 VWC2 VWC2 CYFIP2 CYFIP2 SKIL SKIL CADM4 CADM4 BMPR2 BMPR2 GIPC3 GIPC3 CTNNB1 CTNNB1 SPRY1 SPRY1 DAND5 DAND5 VWC2L VWC2L H3B7E6_LATCH H3B7E6_LATCH CYFIP1 CYFIP1 CD63 CD63 SULF1 SULF1 NPTN NPTN SHISA2 SHISA2 LOC102356742 LOC102356742 LEMD2 LEMD2 H3BA69_LATCH H3BA69_LATCH GIPC1 GIPC1 H3BB14_LATCH H3BB14_LATCH LOC102355199 LOC102355199 FBXL15 FBXL15 BCL9L BCL9L CCN1 CCN1 HOXA13 HOXA13 CRIM1 CRIM1 H3BE69_LATCH H3BE69_LATCH FGFBP3 FGFBP3 H3BEX6_LATCH H3BEX6_LATCH PMEPA1 PMEPA1 TGFB1 TGFB1 THBS1 THBS1 HSPA5 HSPA5 CAV3 CAV3 SPRED3 SPRED3 CREB3L1 CREB3L1 PPM1A PPM1A ZNF703 ZNF703 ARID4A ARID4A PRDM16-2 PRDM16-2 WNT1 WNT1 PRDM16 PRDM16 BMP4 BMP4 ACVRL1 ACVRL1 H3BIS0_LATCH H3BIS0_LATCH RBPMS2 RBPMS2 LOC102358988 LOC102358988 BMPER BMPER VEGFC VEGFC UBE2O UBE2O HGS HGS ENG ENG CREBBP CREBBP AGT AGT NRP1 NRP1 M3XLP3_LATCH M3XLP3_LATCH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DSTYKDual serine/threonine and tyrosine protein kinase. (848 aa)
H2ZRM4_LATCHUncharacterized protein. (379 aa)
LOC102350617Uncharacterized protein. (222 aa)
H2ZTF7_LATCHFam20C domain-containing protein. (511 aa)
CHRDChordin; Belongs to the chordin family. (948 aa)
CCBE1Collagen and calcium binding EGF domains 1. (357 aa)
DCNDecorin; May affect the rate of fibrils formation. (353 aa)
LOC102356560ANK_REP_REGION domain-containing protein. (128 aa)
LOC102353315Uncharacterized protein. (381 aa)
LRG1LRRCT domain-containing protein. (337 aa)
LOC102363464Si:ch211-267e7.3. (924 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
LOC102354291Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
VEPH1-2Uncharacterized protein. (196 aa)
DLX1Distal-less homeobox 1. (253 aa)
LOC102349535Uncharacterized protein. (176 aa)
LOC102350164Uncharacterized protein. (364 aa)
MMRN2Multimerin 2. (911 aa)
CER1CTCK domain-containing protein. (257 aa)
GATA3GATA binding protein 3. (447 aa)
RNF111Ring finger protein 111. (966 aa)
FAM20CFam20C domain-containing protein. (305 aa)
TMEM204Transmembrane protein 204. (228 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (439 aa)
MSX1Msh homeobox 1. (256 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
TNFAIP6TNF alpha induced protein 6. (279 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
LRIT3Leucine rich repeat, Ig-like and transmembrane domains 3. (651 aa)
LOC102358266Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
PRDM14PR/SET domain 14. (599 aa)
SPARTSpartin. (664 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
SNX25Sorting nexin 25. (620 aa)
ZNF451Zinc finger protein 451. (1068 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
ILKIntegrin linked kinase. (417 aa)
JCADJunctional cadherin 5 associated. (1240 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
LOC102352233Uncharacterized protein. (511 aa)
H3AC70_LATCHLRRNT domain-containing protein. (132 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
FKBP8Peptidylprolyl isomerase. (443 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
IL17FInterleukin 17F. (166 aa)
LINGO3Leucine rich repeat and Ig domain containing 3a. (624 aa)
LOC102350487RGM domain family, member D. (443 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
RNF165Ring finger protein 165. (351 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
LOC102351081Bone morphogenetic protein 16. (396 aa)
SIRT1Sirtuin 1. (729 aa)
LOC102352539Uncharacterized protein. (949 aa)
SMAD4MH2 domain-containing protein. (412 aa)
STRAPSerine/threonine kinase receptor associated protein. (329 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SULF2Extracellular sulfatase. (877 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (220 aa)
SFRP1NTR domain-containing protein. (128 aa)
LATS2Large tumor suppressor kinase 2. (1108 aa)
SKOR2SKI family transcriptional corepressor 2. (721 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (535 aa)
FBN1Fibrillin 1. (2872 aa)
ADAMTSL2ADAMTS like 2. (952 aa)
FAM89BFamily with sequence similarity 89 member B. (179 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
FSTL3Follistatin like 3. (248 aa)
FLCNFolliculin. (576 aa)
EMILIN1Elastin microfibril interfacer 1. (1047 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1036 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (678 aa)
SFRP1-2FZ domain-containing protein. (203 aa)
SPRY2Sprouty RTK signaling antagonist 2. (320 aa)
IL17RDInterleukin 17 receptor D. (698 aa)
LATS1Large tumor suppressor kinase 1. (1140 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (692 aa)
LEMD3LEM domain containing 3. (705 aa)
CHRDL1Chordin like 1. (458 aa)
NBL1NBL1, DAN family BMP antagonist. (184 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (518 aa)
SOSTSclerostin. (210 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (310 aa)
SMAD3Mothers against decapentaplegic homolog. (358 aa)
HTRA3HtrA serine peptidase 3. (460 aa)
TBX20T-box transcription factor 20. (441 aa)
C20orf27Chromosome 20 open reading frame 27. (106 aa)
SLIT2Slit guidance ligand 2. (1372 aa)
SORL1Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
SOSTDC1Sclerostin domain containing 1. (213 aa)
CTDSPL2FCP1 homology domain-containing protein. (2335 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
CDH5Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2155 aa)
LOC102357384Noggin; Belongs to the noggin family. (216 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
KIAA1324LKIAA1324 like. (965 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1233 aa)
CHST11Carbohydrate sulfotransferase. (298 aa)
H3AVW8_LATCHMothers against decapentaplegic homolog. (369 aa)
HJVHemojuvelin BMP co-receptor. (404 aa)
FSTFollistatin. (319 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
ZNF423Zinc finger protein 423. (1277 aa)
SPRY4Sprouty RTK signaling antagonist 4. (282 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
SPRY3Sprouty RTK signaling antagonist 3. (296 aa)
ING2Inhibitor of growth protein. (269 aa)
TSPAN12Tetraspanin 12; Belongs to the tetraspanin (TM4SF) family. (236 aa)
DAB2DAB adaptor protein 2. (745 aa)
GIPC2GIPC PDZ domain containing family member 2. (327 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1076 aa)
SNW1SNW domain containing 1. (536 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (167 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (528 aa)
SKISKI proto-oncogene. (702 aa)
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BBIP1Uncharacterized protein. (499 aa)
SFRP5Secreted frizzled related protein 5. (309 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
MYOCDMyocardin. (963 aa)
LOC102360711PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (299 aa)
BMP2Bone morphogenetic protein 2. (402 aa)
SKOR1SKI family transcriptional corepressor 1. (787 aa)
HHIPHedgehog interacting protein. (687 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (556 aa)
TMEM108Transmembrane protein 108. (355 aa)
SMURF2E3 ubiquitin-protein ligase. (754 aa)
VWC2Von Willebrand factor C domain containing 2. (270 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1255 aa)
SKILSKI like proto-oncogene. (691 aa)
CADM4Cell adhesion molecule 4. (380 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
GIPC3GIPC PDZ domain containing family member 3. (319 aa)
CTNNB1Catenin beta 1. (781 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
DAND5CTCK domain-containing protein. (247 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (176 aa)
H3B7E6_LATCHUncharacterized protein. (237 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1259 aa)
CD63Tetraspanin. (270 aa)
SULF1Sulfatase 1. (1129 aa)
NPTNNeuroplastin. (346 aa)
SHISA2Shisa family member 2. (295 aa)
LOC102356742Sizzled. (295 aa)
LEMD2LEM domain containing 2. (416 aa)
H3BA69_LATCHSi:ch73-330k17.3. (196 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
H3BB14_LATCHUncharacterized protein. (123 aa)
LOC102355199Uncharacterized protein. (301 aa)
FBXL15F-box and leucine rich repeat protein 15. (302 aa)
BCL9LBCL9 like. (1514 aa)
CCN1Cellular communication network factor 1. (368 aa)
HOXA13Homeobox A13b. (295 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (881 aa)
H3BE69_LATCHPID domain-containing protein. (136 aa)
FGFBP3Fibroblast growth factor binding protein 3. (239 aa)
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (284 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
THBS1Thrombospondin 1. (1170 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
SPRED3Sprouty related EVH1 domain containing 3. (453 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (481 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
ZNF703Zinc finger protein 703. (539 aa)
ARID4AAT-rich interaction domain 4A. (1297 aa)
PRDM16-2Si:ch211-263k4.2. (114 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
PRDM16PR/SET domain 16. (1135 aa)
BMP4Bone morphogenetic protein 4. (460 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
H3BIS0_LATCHUncharacterized protein. (153 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (227 aa)
LOC102358988Mothers against decapentaplegic homolog. (614 aa)
BMPERBMP binding endothelial regulator. (682 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (410 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1313 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (480 aa)
ENGEndoglin. (674 aa)
CREBBPCREB binding protein. (2411 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (928 aa)
M3XLP3_LATCHUncharacterized protein. (408 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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