(12 nodes) Regulation of DNA methylation-dependent heterochromatin assembly network (Latimeria chalumnae)

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second shell of interactors

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Your Input:
	TASOR	Transcription activation suppressor. (1626 aa)
	H3ARD1_LATCH	DUF3504 domain-containing protein. (294 aa)
	H2ZTU8_LATCH	Uncharacterized protein. (60 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1273 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1312 aa)
	MORC2	MORC family CW-type zinc finger 2. (1039 aa)
	ATF7IP	Activating transcription factor 7 interacting protein. (1260 aa)
	H3AP11_LATCH	Uncharacterized protein. (456 aa)
	SETDB2	SET domain bifurcated histone lysine methyltransferase 2. (751 aa)
	AICDA	Activation-induced cytidine deaminase. (149 aa)
	MPHOSPH8	M-phase phosphoprotein 8. (962 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (820 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	H2ZTU8_LATCH	ENSLACP00000010577	ENSLACP00000000819	Activation-induced cytidine deaminase.	Uncharacterized protein.	0.478
ATF7IP	SETDB1	ENSLACP00000011681	ENSLACP00000012666	Activating transcription factor 7 interacting protein.	SET domain bifurcated histone lysine methyltransferase 1.	0.923
ATF7IP	SETDB2	ENSLACP00000011681	ENSLACP00000010956	Activating transcription factor 7 interacting protein.	SET domain bifurcated histone lysine methyltransferase 2.	0.877
DNMT1	KDM1A	ENSLACP00000012502	ENSLACP00000008333	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.779
DNMT1	SETDB1	ENSLACP00000012502	ENSLACP00000012666	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SET domain bifurcated histone lysine methyltransferase 1.	0.818
DNMT1	SETDB2	ENSLACP00000012502	ENSLACP00000010956	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SET domain bifurcated histone lysine methyltransferase 2.	0.556
H2ZTU8_LATCH	AICDA	ENSLACP00000000819	ENSLACP00000010577	Uncharacterized protein.	Activation-induced cytidine deaminase.	0.478
H3ARD1_LATCH	SETDB1	ENSLACP00000012202	ENSLACP00000012666	DUF3504 domain-containing protein.	SET domain bifurcated histone lysine methyltransferase 1.	0.923
H3ARD1_LATCH	SETDB2	ENSLACP00000012202	ENSLACP00000010956	DUF3504 domain-containing protein.	SET domain bifurcated histone lysine methyltransferase 2.	0.877
KDM1A	DNMT1	ENSLACP00000008333	ENSLACP00000012502	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.779
KDM1A	SETDB1	ENSLACP00000008333	ENSLACP00000012666	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	SET domain bifurcated histone lysine methyltransferase 1.	0.505
KDM1A	SETDB2	ENSLACP00000008333	ENSLACP00000010956	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	SET domain bifurcated histone lysine methyltransferase 2.	0.583
MPHOSPH8	SETDB1	ENSLACP00000009333	ENSLACP00000012666	M-phase phosphoprotein 8.	SET domain bifurcated histone lysine methyltransferase 1.	0.723
MPHOSPH8	SETDB2	ENSLACP00000009333	ENSLACP00000010956	M-phase phosphoprotein 8.	SET domain bifurcated histone lysine methyltransferase 2.	0.640
MPHOSPH8	TASOR	ENSLACP00000009333	ENSLACP00000006284	M-phase phosphoprotein 8.	Transcription activation suppressor.	0.785
SETDB1	ATF7IP	ENSLACP00000012666	ENSLACP00000011681	SET domain bifurcated histone lysine methyltransferase 1.	Activating transcription factor 7 interacting protein.	0.923
SETDB1	DNMT1	ENSLACP00000012666	ENSLACP00000012502	SET domain bifurcated histone lysine methyltransferase 1.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.818
SETDB1	H3ARD1_LATCH	ENSLACP00000012666	ENSLACP00000012202	SET domain bifurcated histone lysine methyltransferase 1.	DUF3504 domain-containing protein.	0.923
SETDB1	KDM1A	ENSLACP00000012666	ENSLACP00000008333	SET domain bifurcated histone lysine methyltransferase 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.505
SETDB1	MPHOSPH8	ENSLACP00000012666	ENSLACP00000009333	SET domain bifurcated histone lysine methyltransferase 1.	M-phase phosphoprotein 8.	0.723