(25 nodes) Negative regulation of intracellular protein transport network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	DMTN	Dematin actin binding protein. (406 aa)
	YOD1	YOD1 deubiquitinase. (304 aa)
	DERL3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (203 aa)
	BARD1	BRCA1 associated RING domain 1. (866 aa)
	APOD	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	SIRT6	Sirtuin 6. (375 aa)
	LOC102347917	Uncharacterized protein. (301 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	UBE2J1	Ubiquitin conjugating enzyme E2 J1. (321 aa)
	ERLEC1	Endoplasmic reticulum lectin 1. (486 aa)
	BAG4	BCL2 associated athanogene 4. (454 aa)
	BAG3	BCL2 associated athanogene 3. (561 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	RANGAP1	Ran GTPase activating protein 1. (615 aa)
	UBE2G2	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
	SVIP	Si:ch73-147o17.1. (80 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	NF1	Neurofibromin 1. (2814 aa)
	DERL2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	OS9	OS9 endoplasmic reticulum lectin. (662 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
BAG3	BAG4	ENSLACP00000012843	ENSLACP00000012598	BCL2 associated athanogene 3.	BCL2 associated athanogene 4.	0.563
BAG4	BAG3	ENSLACP00000012598	ENSLACP00000012843	BCL2 associated athanogene 4.	BCL2 associated athanogene 3.	0.563
BARD1	UBE2J1	ENSLACP00000022324	ENSLACP00000011151	BRCA1 associated RING domain 1.	Ubiquitin conjugating enzyme E2 J1.	0.538
DERL2	ERLEC1	ENSLACP00000020713	ENSLACP00000007837	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.937
DERL2	OS9	ENSLACP00000020713	ENSLACP00000020725	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.937
DERL2	UBE2G2	ENSLACP00000020713	ENSLACP00000016288	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.439
DERL2	UBE2J1	ENSLACP00000020713	ENSLACP00000011151	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 J1.	0.512
DERL3	ERLEC1	ENSLACP00000011180	ENSLACP00000007837	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.937
DERL3	OS9	ENSLACP00000011180	ENSLACP00000020725	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.937
DERL3	UBE2G2	ENSLACP00000011180	ENSLACP00000016288	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.439
DERL3	UBE2J1	ENSLACP00000011180	ENSLACP00000011151	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin conjugating enzyme E2 J1.	0.512
ERLEC1	DERL2	ENSLACP00000007837	ENSLACP00000020713	Endoplasmic reticulum lectin 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.937
ERLEC1	DERL3	ENSLACP00000007837	ENSLACP00000011180	Endoplasmic reticulum lectin 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.937
ERLEC1	UBE2G2	ENSLACP00000007837	ENSLACP00000016288	Endoplasmic reticulum lectin 1.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.476
ERLEC1	UBE2J1	ENSLACP00000007837	ENSLACP00000011151	Endoplasmic reticulum lectin 1.	Ubiquitin conjugating enzyme E2 J1.	0.575
LOC102346019	ADIPOQ	ENSLACP00000019134	ENSLACP00000000452	C1q domain-containing protein.	Adiponectin, C1Q and collagen domain containing.	0.904
OS9	DERL2	ENSLACP00000020725	ENSLACP00000020713	OS9 endoplasmic reticulum lectin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.937
OS9	DERL3	ENSLACP00000020725	ENSLACP00000011180	OS9 endoplasmic reticulum lectin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.937
OS9	UBE2G2	ENSLACP00000020725	ENSLACP00000016288	OS9 endoplasmic reticulum lectin.	Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.	0.476