(23 nodes) Regulation of plasma lipoprotein particle levels network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (430 aa)
	MTTP	Microsomal triglyceride transfer protein. (893 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (711 aa)
	APOM	Apolipoprotein M. (194 aa)
	DGAT1	O-acyltransferase. (422 aa)
	PLAGL2	PLAG1 like zinc finger 2. (507 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (468 aa)
	LIPC	Lipase C, hepatic type. (503 aa)
	SOAT1	O-acyltransferase. (545 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1b. (316 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (549 aa)
	LOC102350159	Vitellogenin domain-containing protein. (663 aa)
	LOC102365332	Apolipoprotein Ea. (278 aa)
	APOA4	Apolipoprotein A4. (367 aa)
	SOAT2	O-acyltransferase. (507 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (488 aa)
	H3BF51_LATCH	Uncharacterized protein. (492 aa)
	PLTP	Phospholipid transfer protein. (495 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (428 aa)
	APOB	Apolipoprotein B. (4644 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL3	LIPC	ENSLACP00000004477	ENSLACP00000011326	Acyl-CoA synthetase long chain family member 3.	Lipase C, hepatic type.	0.607
ACSL3	LPL	ENSLACP00000004477	ENSLACP00000020495	Acyl-CoA synthetase long chain family member 3.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.803
ADIPOQ	APOB	ENSLACP00000000452	ENSLACP00000022987	Adiponectin, C1Q and collagen domain containing.	Apolipoprotein B.	0.526
ADIPOQ	CD36	ENSLACP00000000452	ENSLACP00000007631	Adiponectin, C1Q and collagen domain containing.	CD36 molecule; Belongs to the CD36 family.	0.559
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	SCARB1	ENSLACP00000000452	ENSLACP00000023060	Adiponectin, C1Q and collagen domain containing.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.417
APOA4	APOB	ENSLACP00000016757	ENSLACP00000022987	Apolipoprotein A4.	Apolipoprotein B.	0.787
APOA4	APOM	ENSLACP00000016757	ENSLACP00000004816	Apolipoprotein A4.	Apolipoprotein M.	0.461
APOA4	LCAT	ENSLACP00000016757	ENSLACP00000022134	Apolipoprotein A4.	Lecithin-cholesterol acyltransferase.	0.470
APOA4	LOC102365332	ENSLACP00000016757	ENSLACP00000016337	Apolipoprotein A4.	Apolipoprotein Ea.	0.860
APOA4	MTTP	ENSLACP00000016757	ENSLACP00000002839	Apolipoprotein A4.	Microsomal triglyceride transfer protein.	0.429
APOB	ADIPOQ	ENSLACP00000022987	ENSLACP00000000452	Apolipoprotein B.	Adiponectin, C1Q and collagen domain containing.	0.526
APOB	APOA4	ENSLACP00000022987	ENSLACP00000016757	Apolipoprotein B.	Apolipoprotein A4.	0.787
APOB	CD36	ENSLACP00000022987	ENSLACP00000007631	Apolipoprotein B.	CD36 molecule; Belongs to the CD36 family.	0.930
APOB	LCAT	ENSLACP00000022987	ENSLACP00000022134	Apolipoprotein B.	Lecithin-cholesterol acyltransferase.	0.644
APOB	LDLRAP1	ENSLACP00000022987	ENSLACP00000013427	Apolipoprotein B.	Low density lipoprotein receptor adaptor protein 1b.	0.805
APOB	LIPC	ENSLACP00000022987	ENSLACP00000011326	Apolipoprotein B.	Lipase C, hepatic type.	0.885
APOB	LOC102346019	ENSLACP00000022987	ENSLACP00000019134	Apolipoprotein B.	C1q domain-containing protein.	0.450
APOB	LOC102350159	ENSLACP00000022987	ENSLACP00000014877	Apolipoprotein B.	Vitellogenin domain-containing protein.	0.934
APOB	LOC102365332	ENSLACP00000022987	ENSLACP00000016337	Apolipoprotein B.	Apolipoprotein Ea.	0.922