(28 nodes) Energy homeostasis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	MLXIPL	MLX interacting protein like. (862 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	LOC102345440	Nuclear receptor subfamily 1, group D, member 4b. (554 aa)
	PM20D1	Peptidase M20 domain containing 1. (517 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	MRAP2	Melanocortin 2 receptor accessory protein 2. (163 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family. (644 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (549 aa)
	SQSTM1	Sequestosome 1. (441 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	IRX3	Iroquois homeobox 3. (447 aa)
	FLCN	Folliculin. (576 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LEPR	Leptin receptor. (1149 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (367 aa)
	CRTC3	CREB regulated transcription coactivator 3. (642 aa)
	OMA1	OMA1 zinc metallopeptidase. (358 aa)
	LOC102345119	Uncharacterized protein. (326 aa)
	RRP8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (469 aa)
	LOC102367486	Uncharacterized protein. (419 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (823 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (592 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	CRTC1	CREB regulated transcription coactivator 1. (615 aa)
	METRNL	Meteorin like, glial cell differentiation regulator. (288 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
LEPR	STAT3	ENSLACP00000008593	ENSLACP00000013656	Leptin receptor.	Signal transducer and activator of transcription.	0.722
LOC102351332	STAT3	ENSLACP00000013502	ENSLACP00000013656	Zgc:158659; Belongs to the PI3/PI4-kinase family.	Signal transducer and activator of transcription.	0.413
METRNL	SIRT1	ENSLACP00000005395	ENSLACP00000009079	Meteorin like, glial cell differentiation regulator.	Sirtuin 1.	0.632
NR1D2	PPARGC1A	ENSLACP00000003604	ENSLACP00000015962	Nuclear receptor subfamily 1 group D member 2.	PPARG coactivator 1 alpha.	0.560
PIK3CA	PRKAA1	ENSLACP00000017606	ENSLACP00000003950	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Non-specific serine/threonine protein kinase.	0.442
PIK3CA	STAT3	ENSLACP00000017606	ENSLACP00000013656	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Signal transducer and activator of transcription.	0.413
PPARGC1A	NR1D2	ENSLACP00000015962	ENSLACP00000003604	PPARG coactivator 1 alpha.	Nuclear receptor subfamily 1 group D member 2.	0.560
PPARGC1A	PRKAA1	ENSLACP00000015962	ENSLACP00000003950	PPARG coactivator 1 alpha.	Non-specific serine/threonine protein kinase.	0.545
PPARGC1A	SIRT1	ENSLACP00000015962	ENSLACP00000009079	PPARG coactivator 1 alpha.	Sirtuin 1.	0.789
PRKAA1	PIK3CA	ENSLACP00000003950	ENSLACP00000017606	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.442
PRKAA1	PPARGC1A	ENSLACP00000003950	ENSLACP00000015962	Non-specific serine/threonine protein kinase.	PPARG coactivator 1 alpha.	0.545
PRKAA1	SIRT1	ENSLACP00000003950	ENSLACP00000009079	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.473
RRP8	SIRT1	ENSLACP00000001395	ENSLACP00000009079	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Sirtuin 1.	0.922
SIRT1	METRNL	ENSLACP00000009079	ENSLACP00000005395	Sirtuin 1.	Meteorin like, glial cell differentiation regulator.	0.632
SIRT1	PPARGC1A	ENSLACP00000009079	ENSLACP00000015962	Sirtuin 1.	PPARG coactivator 1 alpha.	0.789
SIRT1	PRKAA1	ENSLACP00000009079	ENSLACP00000003950	Sirtuin 1.	Non-specific serine/threonine protein kinase.	0.473
SIRT1	RRP8	ENSLACP00000009079	ENSLACP00000001395	Sirtuin 1.	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	0.922
SIRT1	SQSTM1	ENSLACP00000009079	ENSLACP00000013831	Sirtuin 1.	Sequestosome 1.	0.456