(61 nodes) Extrinsic apoptotic signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	FGFR3	Fibroblast growth factor receptor. (778 aa)
	DAXX	Death-domain associated protein. (728 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1555 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (539 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (579 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (433 aa)
	MLLT11	MLLT11 transcription factor 7 cofactor. (85 aa)
	H3A2R2_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	SIVA1	SIVA1 apoptosis inducing factor. (168 aa)
	PARP2	Poly [ADP-ribose] polymerase. (502 aa)
	H3A526_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
	INHBA	Inhibin subunit beta A. (390 aa)
	FAS	Uncharacterized protein. (330 aa)
	ITPRIP	Inositol 1,4,5-trisphosphate receptor interacting protein. (546 aa)
	BCL2L2	BCL2 like 2. (189 aa)
	BAX	Uncharacterized protein. (223 aa)
	GSK3A	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (463 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	LOC102362452	Uncharacterized protein. (176 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	RB1CC1	RB1-inducible coiled-coil 1. (1296 aa)
	BOK	BCL2 family apoptosis regulator BOK. (111 aa)
	FADD	Fas associated via death domain. (193 aa)
	BCL2L10	BCL2 like 10. (178 aa)
	H3AMM0_LATCH	ATG11 domain-containing protein. (241 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	BAD	Uncharacterized protein. (175 aa)
	BCL2L1	BCL2 like 1. (239 aa)
	ITPRIPL2	ITPRIP like 2. (504 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (207 aa)
	LOC102359041	Zgc:153993. (208 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	BAG3	BCL2 associated athanogene 3. (561 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	PDIA3	Protein disulfide-isomerase. (497 aa)
	DDX47	DEAD-box helicase 47; Belongs to the DEAD box helicase family. (453 aa)
	SKIL	SKI like proto-oncogene. (691 aa)
	WWOX	WW domain containing oxidoreductase. (353 aa)
	FASLG	Fas ligand. (261 aa)
	TRADD	Death domain-containing protein. (313 aa)
	SORT1	Sortilin. (734 aa)
	H3B707_LATCH	Uncharacterized protein. (393 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	NF1	Neurofibromin 1. (2814 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	RNF41	Ring finger protein 41. (319 aa)
	LOC102348948	IF rod domain-containing protein; Belongs to the intermediate filament family. (548 aa)
	LOC102349393	IF rod domain-containing protein; Belongs to the intermediate filament family. (514 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (272 aa)
	G0S2	G0/G1 switch 2. (100 aa)
	ACVR1B	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
	DELE1	Uncharacterized protein. (461 aa)
	LOC102345670	Sortilin. (809 aa)
	M3XHJ5_LATCH	Uncharacterized protein. (158 aa)
	M3XHT8_LATCH	Uncharacterized protein. (197 aa)
	DEDD2	Death effector domain containing 2. (372 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (465 aa)
	TNFSF12	TNF superfamily member 12; Belongs to the tumor necrosis factor family. (246 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1B	INHBA	ENSLACP00000021755	ENSLACP00000005541	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin subunit beta A.	0.968
ACVR1B	LOC102352268	ENSLACP00000021755	ENSLACP00000019574	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.487
ACVR1B	TGFB1	ENSLACP00000021755	ENSLACP00000020652	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.816
ACVR1B	TGFB2	ENSLACP00000021755	ENSLACP00000007733	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.487
BAD	BAK1	ENSLACP00000011265	ENSLACP00000018296	Uncharacterized protein.	BCL2 antagonist/killer 1.	0.786
BAD	BAX	ENSLACP00000011265	ENSLACP00000007049	Uncharacterized protein.	Uncharacterized protein.	0.754
BAD	BCL2L1	ENSLACP00000011265	ENSLACP00000011299	Uncharacterized protein.	BCL2 like 1.	0.966
BAD	BCL2L10	ENSLACP00000011265	ENSLACP00000010648	Uncharacterized protein.	BCL2 like 10.	0.754
BAD	BCL2L2	ENSLACP00000011265	ENSLACP00000006748	Uncharacterized protein.	BCL2 like 2.	0.830
BAD	BOK	ENSLACP00000011265	ENSLACP00000009914	Uncharacterized protein.	BCL2 family apoptosis regulator BOK.	0.769
BAD	LOC102359041	ENSLACP00000011265	ENSLACP00000012675	Uncharacterized protein.	Zgc:153993.	0.771
BAD	M3XHJ5_LATCH	ENSLACP00000011265	ENSLACP00000022201	Uncharacterized protein.	Uncharacterized protein.	0.788
BAD	MCL1	ENSLACP00000011265	ENSLACP00000012090	Uncharacterized protein.	MCL1 apoptosis regulator, BCL2 family member.	0.757
BAG3	LOC102348948	ENSLACP00000012843	ENSLACP00000020107	BCL2 associated athanogene 3.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.578
BAG3	LOC102349393	ENSLACP00000012843	ENSLACP00000020150	BCL2 associated athanogene 3.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.578
BAG3	TRADD	ENSLACP00000012843	ENSLACP00000017534	BCL2 associated athanogene 3.	Death domain-containing protein.	0.481
BAK1	BAD	ENSLACP00000018296	ENSLACP00000011265	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.786
BAK1	BAX	ENSLACP00000018296	ENSLACP00000007049	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.985
BAK1	BCL2L1	ENSLACP00000018296	ENSLACP00000011299	BCL2 antagonist/killer 1.	BCL2 like 1.	0.968
BAK1	BCL2L10	ENSLACP00000018296	ENSLACP00000010648	BCL2 antagonist/killer 1.	BCL2 like 10.	0.424