STRINGSTRING
TP53 TP53 H2ZV40_LATCH H2ZV40_LATCH H2ZS97_LATCH H2ZS97_LATCH RIPK1 RIPK1 DNM1L DNM1L CYLD CYLD FADD FADD ALKBH7 ALKBH7 H3AEV1_LATCH H3AEV1_LATCH BAX BAX FAS FAS MLKL MLKL IPMK IPMK ITPK1 ITPK1 LOC102366649 LOC102366649 PGAM5 PGAM5 IRF3 IRF3 FASLG FASLG LOC102360171 LOC102360171 TLR3 TLR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
H2ZV40_LATCHProtein kinase domain-containing protein. (266 aa)
H2ZS97_LATCHTNF_2 domain-containing protein. (143 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (778 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (959 aa)
FADDFas associated via death domain. (193 aa)
ALKBH7AlkB homolog 7. (231 aa)
H3AEV1_LATCHTNF_2 domain-containing protein. (230 aa)
BAXUncharacterized protein. (223 aa)
FASUncharacterized protein. (330 aa)
MLKLProtein kinase domain-containing protein. (520 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (357 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase. (406 aa)
LOC102366649Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (357 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (293 aa)
IRF3Interferon regulatory factor 3. (481 aa)
FASLGFas ligand. (261 aa)
LOC102360171Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (426 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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