(91 nodes) Response to alcohol network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBXA2R	Thromboxane A2 receptor. (351 aa)
	BRCA1	BRCA1 DNA repair associated. (1873 aa)
	LOC102345588	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (377 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	LOC102364376	Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
	CLDN1	Claudin 1. (210 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	CREB1	cAMP responsive element binding protein 1. (347 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (273 aa)
	GRAMD1B	GRAM domain containing 1Bb. (692 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2644 aa)
	LARP1	La ribonucleoprotein domain family member 1. (933 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC102362374	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (316 aa)
	ADCY6	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1491 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (240 aa)
	HSD3B7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (377 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (835 aa)
	PMVK	Phosphomevalonate kinase. (188 aa)
	H2ZYP2_LATCH	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	GOLPH3	Golgi phosphoprotein 3. (294 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1088 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	LOC102365646	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	H3AQU6_LATCH	AC_N domain-containing protein. (191 aa)
	ADCY8	AC_N domain-containing protein. (266 aa)
	H3ALW6_LATCH	Uncharacterized protein. (286 aa)
	AKAP8	A-kinase anchoring protein 8; Belongs to the AKAP95 family. (699 aa)
	XRN1	5'-3' exoribonuclease 1. (1737 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (402 aa)
	TUFM	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (453 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1450 aa)
	ADCY5	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (824 aa)
	MLC1	Modulator of VRAC current 1. (378 aa)
	CYP7A1	Cytochrome P450 family 7 subfamily A member 1. (514 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	SLC10A1	Solute carrier family 10 member 1. (365 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (323 aa)
	NPAS4	Neuronal PAS domain protein 4. (731 aa)
	BLM	BLM RecQ like helicase. (1450 aa)
	DBH	Dopamine beta-hydroxylase. (617 aa)
	H3AC70_LATCH	LRRNT domain-containing protein. (132 aa)
	H3ABV0_LATCH	Tyrosine hydroxylase. (247 aa)
	LOC102354799	Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
	H3AB79_LATCH	Uncharacterized protein. (135 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
	LOC102349421	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (185 aa)
	LOC102362765	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (430 aa)
	SLIT3	Slit guidance ligand 3. (635 aa)
	LOC102358504	SCY domain-containing protein. (118 aa)
	OPRD1	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (145 aa)
	RGS19	Regulator of G protein signaling 19. (152 aa)
	LOC102356233	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
	GRAMD1A	GRAM domain containing 1A. (864 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	PTCH1	Patched 1. (1287 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (314 aa)
	GRAMD1C	GRAM domain containing 1C. (564 aa)
	PODN	Podocan. (621 aa)
	H3A8P8_LATCH	DUF4502 domain-containing protein. (165 aa)
	PODNL1	Podocan like 1. (599 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (268 aa)
	ADCYAP1R1	ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (337 aa)
	PTGFR	Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1099 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC102350473	Tyrosine hydroxylase 2. (425 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
	RECQL5	RecQ like helicase 5. (1041 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
	NR0B2	Nuclear receptor subfamily 0 group B member 2. (260 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1109 aa)
	LOC102359041	Zgc:153993. (208 aa)
	JUP	Junction plakoglobin. (694 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (553 aa)
	LOC102351204	DUF1053 domain-containing protein. (254 aa)
	ADCY5-2	AC_N domain-containing protein. (323 aa)
	SPIDR	DUF4503 domain-containing protein. (397 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY3	ADCY5	ENSLACP00000015140	ENSLACP00000009121	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.546
ADCY3	ADCY5-2	ENSLACP00000015140	ENSLACP00000006513	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.484
ADCY3	ADCY6	ENSLACP00000015140	ENSLACP00000019614	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.539
ADCY3	ADCY8	ENSLACP00000015140	ENSLACP00000011649	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.671
ADCY3	H3AQU6_LATCH	ENSLACP00000015140	ENSLACP00000012017	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.544
ADCY3	LOC102351204	ENSLACP00000015140	ENSLACP00000006503	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	DUF1053 domain-containing protein.	0.544
ADCY5	ADCY3	ENSLACP00000009121	ENSLACP00000015140	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.546
ADCY5	ADCY5-2	ENSLACP00000009121	ENSLACP00000006513	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.832
ADCY5	ADCY8	ENSLACP00000009121	ENSLACP00000011649	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.944
ADCY5	H3AQU6_LATCH	ENSLACP00000009121	ENSLACP00000012017	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.917
ADCY5-2	ADCY3	ENSLACP00000006513	ENSLACP00000015140	AC_N domain-containing protein.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.484
ADCY5-2	ADCY5	ENSLACP00000006513	ENSLACP00000009121	AC_N domain-containing protein.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.832
ADCY5-2	ADCY6	ENSLACP00000006513	ENSLACP00000019614	AC_N domain-containing protein.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.900
ADCY5-2	ADCY8	ENSLACP00000006513	ENSLACP00000011649	AC_N domain-containing protein.	AC_N domain-containing protein.	0.946
ADCY6	ADCY3	ENSLACP00000019614	ENSLACP00000015140	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.539
ADCY6	ADCY5-2	ENSLACP00000019614	ENSLACP00000006513	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.900
ADCY6	ADCY8	ENSLACP00000019614	ENSLACP00000011649	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.946
ADCY8	ADCY3	ENSLACP00000011649	ENSLACP00000015140	AC_N domain-containing protein.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.671
ADCY8	ADCY5	ENSLACP00000011649	ENSLACP00000009121	AC_N domain-containing protein.	Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.944
ADCY8	ADCY5-2	ENSLACP00000011649	ENSLACP00000006513	AC_N domain-containing protein.	AC_N domain-containing protein.	0.946